Filtyp
Symptoms of infection and tissue pathology are caused by the host response; not by the microbe per se. The same response is also critical for the defence and is needed to clear infection. It is therefore essential to understand how the host response is activated and to identify the critical effector mechanisms of the defence. We have studied these issues in the urinary tract infection (UTI) model.
Objective Cell free foetal DNA (cff DNA) extracted from maternal plasma is now recognized as a potential source for prenatal diagnosis but the methodology is currently not well standardized. To evaluate different manual and automated DNA extraction methods with a view to developing standards, an International Workshop was performed. Methods Three plasma pools from RhD-negative pregnant women, a DN
Screening women for lower genital tract infection with Chlamydia trachomatis is important in the prevention of pelvic inflammatory disease, ectopic pregnancy and infertility. This systematic review aims to state clearly which of the available diagnostic tests for the detection of C. trachomatis would be most effective in terms of clinical effectiveness. The review included all studies published fr
A list of 1719 chemical compounds identified from headspace samples of floral scent is presented. The list has been compiled from some 270 published papers, including analyses of 991 species of flowering plants and a few gymnosperms, a sample including seed plants from 90 families and 38 orders. The compounds belong to seven major compound classes, of which the aliphatics, the benzenoids and pheny
We present two new methods for finding a lowest common ancestor (LCA) for each pair of vertices of a directed acyclic graph (dag) on n vertices and m edges. The first method is surprisingly natural and solves the all-pairs LCA problem for the input dag on n vertices and m edges in time 0 (n m). The second method relies on a novel reduction of the all-pairs LCA problem to the problem of finding max
Background. Umbilical artery Doppler velocimetry is a routine method for fetal surveillance in high-risk pregnancy. Uterine artery Doppler seems to give comparable information, but it can be difficult to interpret as there are two arteries, which might show notching and/or increased pulsatility index (PI) as signs of increased vascular impedance. Combining the information on vascular resistance on
A novel design of a biochemical oxygen demand (BOD) biosensor has been developed for on-line monitoring of easily biodegradable organic compounds in aqueous samples. The biological recognition element of the sensor could be easily renewed by injecting new bacterial paste without disassembling the sensor system. The sensor measurements were carried out in the initial-rate mode using a flow injectio
Background In vivo measurement of wear in the ball and socket articulation of total hip arthroplasties is of interest in the evaluation of both existing and new implants. Controversy reigns regarding the accuracy of different radiological measurement techniques and in particular how accuracy has been assessed. Material and methods We assessed the accuracy of 2 radiostereometric (RSA) techniques f
Popular Abstract in Swedish Populärvetenskaplig sammanfattning Vilka är egentligen ”de äldre”? Vad innebär det att vara pensionär? Hur ska man åldras på rätt sätt? Frågor som dessa har under det nyss avslutade århundradet ställts och besvarats på många oliks sätt, beroende av sammanhang och tidsperiod. I vissa situationer har de äldres olikhet lyfts fram, i andra deras likhet. Ibland har åldrandetThe aim of the dissertation is to describe images of old age in the magazines of Sweden’s two largest pensioner organizations, and explain the character of those images in relation to the temporal contexts of the organizations and their aim to act as the representatives of pensioners. The study is based on the 329 and 330 magazines (1941–1995) that the organizations have submitted to attract membe
This study is about how the 'global' becomes localized and how the 'local' is articulated through the 'global'. It deals with the Van (forest) Gujjars, a people of nomadic forest pastoralists who inhabit the Central Himalayas of India. The study has two main foci: One is the everyday life-world of the Van Gujjars in the forest - a Van Gujjar ethnography - and the other is the conflict over 'conser
BACKGROUND AND AIMS: The optimal position for pH electrode placement in the diagnosis of gastroesophageal reflux disease (GERD) is unknown. The aim of this study was to evaluate the discriminatory power of targeted pH recording immediately above the squamocolumnar junction (SCJ) and to compare the results with those obtained by simultaneous recording at the conventional level for pH monitoring. SU
Background: nonacog beta pegol (N9-GP) is a glycoPEGylated recombinant factor IX (rFIX) molecule with a prolonged half-life. Objectives: To provide information on potential dose regimens for N9-GP for phase 3 pivotal and surgery trials. Methods: A population pharmacokinetic model was developed from single-dose data derived from the first human dose trial with N9-GP in hemophilia B patients, and wa
The need for new renewable products has enhanced the interest in cellulose and hemicellulose as raw material. The wood plant cell wall is a complex mixture of cellulose, hemicellulose, lignin and minor amounts of pectin, proteins and extractives. Several interactions between the compounds make them difficult to separate without modification. O-acetyl-galactoglucomannan (O-acetyl-GGM), the major he
Popular Abstract in Swedish När ett barn föds före graviditetsvecka 30 är andningsinsufficiens eller på engelska kallad respiratory distress syndrome (RDS) ett av de stora kliniska problemen som barnläkaren står inför. Redan på 1920-talet förstod man att det måste finnas ett ytspänningsnedsättande ämne i lungorna och på 1950-talet fann man att för tidigt födda (prematura) barn med RDS hade brist p
Prostate-specific antigen (PSA) is a glycoprotein produced by the prostate gland. It occurs in several molecular forms in the blood and assays have been developed to measure free PSA and PSA in complex with alpha-1-antichymotrypsin (PSA-ACT). Higher proportions of free PSA (PSA-F/T) in blood are found in subjects with benign prostatic hyperplasia (BPH) as compared to cancer patients. Utilizing imm
Conventional power plants based on fossil fuel without CO2 capture produce flue gas streams with concentrations Of CO2 between 3% and 15%, contributing to the threat of increasing global warming. Existing capture technologies such as post-combustion flue gas treatment using chemical absorption or pre-combustion carbon removal suffer from significant efficiency penalties as well as major increase i
Popular Abstract in Swedish 1: Tomas Åkerud, doktorand vid Lunds Universitet, har utvecklat en metod för att mäta hur snabbt läkemedelsmolekyler och fettsyror (de naturliga bindarna) tar sig in i och lämnar bindingsfickan i ett protein som är viktigt för fettsyrametabolismen i människa. Proteinet, adipocyt-fettsyrabindande protein (A-FABP), har som funktion att transportera fettsyror, som inte är Nuclear magnetic resonance spectroscopy (NMR) has been used to determine the kinetics of ligand binding to the adipocyte fatty acid-binding protein (A-FABP), as well as the oligomerisation and inter- and intramolecular dynamics of the low molecular weight-protein tyrosine phosphatase (LMW-PTP) in solution. NMR spectroscopy is sensitive to dynamic processes on timescales ranging from picoseconds t
Polyiodides and binary metal iodide-iodine compounds have been prepared and investigated by means of X-ray diffraction, EXAFS, far-IR, Raman, UV-vis and NMR spectroscopy and quantum chemical calculations. (Et3S)[AuI4].2I2 and (Me3S)[Cd2I6]1/2.3I2 were synthesised through the reaction between the room temperature melt of trialkylsulfonium polyiodides and the corresponding metal iodides. The structu
