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Reducing the Uncertainty on the Hubble Constant up to 35% with an Improved Statistical Analysis : Different Best-fit Likelihoods for Type Ia Supernovae, Baryon Acoustic Oscillations, Quasars, and Gamma-Ray Bursts

Cosmological models and their parameters are widely debated, especially about whether the current discrepancy between the values of the Hubble constant, H 0, obtained by Type Ia supernovae (SNe Ia) and the Planck data from the cosmic microwave background radiation could be alleviated when alternative cosmological models are considered. Thus, combining high-redshift probes, such as gamma-ray bursts

Factors associated with fatigue in hip and/or knee osteoarthritis : A systematic review and best evidence synthesis

Objective: The aim was systematically to identify and evaluate factors related to fatigue in individuals with hip and/or knee OA. Methods: A systematic literature search was conducted using AMED, CINAHL, MEDLINE, ProQuest and Web of Science Core Collections databases. Inclusion criteria comprised cross-sectional, case-control or longitudinal studies on patients with a diagnosis of hip and/or knee

Energy communities in different national settings – barriers, enablers and best practices

The NEWCOMERS project aims to explore how new clean energy communities (ECs) develop, under which polycentric settings ECs evolve and under what conditions such initiatives are suppressed. At a national level, the project will assess socio-economic, technical, institutional characteristics and actors supporting the emergence of new clean energy communities. In Deliverable 3.1. and 3.2. the nationa

Best practice approaches to social prescribing in European Primary Care : A Delphi protocol focused on link workers

INTRODUCTION: Social prescribing (SP) is an innovative model that connects individuals to non-clinical community resources. However, its uptake and evaluation have been hindered by inconsistent role definitions for key stakeholders. Although recent studies have refined SP definitions, outside the UK, the responsibilities, educational backgrounds and training requirements of social prescribing link

The best fixation target revisited : New insights from retinal eye tracking

In many tasks, participants are instructed to fixate a target. While maintaining fixation, the eyes nonetheless make small fixational eye movements, such as microsaccades and drift. Previous work has examined the effect of fixation point design on fixation stability and the amount and spatial extent of fixational eye movements. However, much of this work used video-based eye trackers, which have i

Validation status of cognitive digital assessments by the FDA BEST framework and context of use in preclinical AD studies : A systematic review

Digital cognitive assessments have rapidly expanded in Alzheimer's disease (AD) research, offering a sensitive, scalable, and cost-effective alternative to traditional neuropsychological tests. This systematic review examines the validation and utility of digital cognitive assessments in cognitively normal (CN) individuals and explores their potential classification within the US Food and Drug Adm

Sudden cardiac death in childhood hypertrophic cardiomyopathy is best predicted by a combination of electrocardiogram risk-score and HCMRisk-Kids score

Aim: To compare risk algorithms (HCMRisk-Kids, ECG Risk-score) in hypertrophic cardiomyopathy (HCM) without syndrome association (ns-HCM) and with Noonan-like syndromes (RAS-HCM). Methods: A national paediatric HCM cohort (n = 151), presenting <19 years of age, mean follow-up 13.3 years, from all Swedish centres of Paediatric Cardiology (presenting 1972–2015), with 41 RAS-HCM patients (61% males),

Human and pathogen genotype-by-genotype interactions in the light of coevolution theory

Antagonistic coevolution (i.e., reciprocal adaptation and counter-adaptation) between hosts and pathogens has long been considered an important driver of genetic variation. However, direct evidence for this is still scarce, especially in vertebrates. The wealth of data on genetics of susceptibility to infectious disease in humans provides an important resource for understanding host-pathogen coevo

Early management of acute pancreatitis : A review of the best evidence

In the 20th century early management of acute pancreatitis often included surgical intervention, despite overwhelming mortality. The emergence of high-quality evidence (randomized controlled trials and meta-analyses) over the past two decades has notably shifted the treatment paradigm towards predominantly non-surgical management early in the course of acute pancreatitis. The present evidence-base

Clinical Practice Guideline on management of older patients with chronic kidney disease stage 3b or higher (EGFR<45 mL/min/1.73 m2) : A summary document from the European Renal Best Practice Group

The population of patients with moderate and severe CKD is growing. Frail and older patients comprise an increasing proportion. Many studies still exclude this group, so the evidence base is limited. In 2013 the advisory board of ERBP initiated, in collaboration with European Union of Geriatric Medicine Societies (EUGMS), the development of a guideline on the management of older patients with CKD

"They do what they think is the best for me." Frail elderly patients' preferences for participation in their care during hospitalization

OBJECTIVE: To deepen the knowledge of frail elderly patients' preferences for participation in medical decision making during hospitalization.METHODS: Qualitative study using content analysis of semi-structured interviews.RESULTS: Patient participation to frail elderly means information, not the wish to take part in decisions about their medical treatments. They view the hospital care system as an

Structural guarantees for the state aid field. The community's last best hope against national arbitrariness

In line with current tendencies of ‘new modes of governance’, this essay introduces judicial tools, which strike a balance between the respect for national autonomy in individual assessments and the effective implementation of Community law. The balance is struck through the demands of structural guarantees; administrative safeguards, which weed out arbitrary national decision-making. These admini

Best Practice Guideline: Transportation of People Seated in Wheelchairs, Version 2.21.

Summary, key points: Transport considerations ought to be factored into the initial phase of the wheelchair & seating assessment process. Manufacturers of wheelchairs and seating systems should make information relating to the safe transportation of their products readily available - and easy to understand. With the desire to provide the safest possible transport environment for wheelchair-se