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Rapport Tematiska Samverkansinitiativ 2021 (2)

Tematiska samverkansinitiativ vid Lunds universitet European Environment Agency Myndigheten för tillgängliga medier Malmö universitetSigma Connectivity University of Wisconsin at Madison US Jonas Enebrand AB eFrid Kulturen i Lund Pensionsmyndigheten CR Competence AB WIN Water Pensionärernas riksförbund Riksarkivet Wrams-Gunnarstorp Gods AB Open University UK Skånes universitetssjukhus European Spa

https://www.konstnarliga.lu.se/sites/konstnarliga.lu.se/files/2023-03/Rapport%20Tematiska%20samverkansinitiativ%202021%20(2).pdf - 2026-05-14

Metformin-induced suppression of Nemo-like kinase improves erythropoiesis in preclinical models of Diamond–Blackfan anemia through induction of miR-26a

Diamond–Blackfan anemia (DBA) results from haploinsufficiency of ribosomal protein subunits in hematopoietic progenitors in the earliest stages of committed erythropoiesis. Nemo-like kinase (NLK) is chronically hyperactivated in committed erythroid progenitors and precursors in multiple human and murine models of DBA. Inhibition of NLK activity and suppression of NLK expression both improve erythr

The Impact of Quadrivalent Human Papillomavirus (HPV; Types 6, 11, 16, and 18) L1 Virus-Like Particle Vaccine on Infection and Disease Due to Oncogenic Nonvaccine HPV Types in Sexually Active Women Aged 16-26 Years

Background. We evaluated the impact of a quadrivalent human papillomavirus (HPV) vaccine on infection and cervical disease related to 10 nonvaccine HPV types (31, 33, 35, 39, 45, 51, 52, 56, 58, and 59) associated with >20% of cervical cancers. The population evaluated included HPV-naive women and women with preexisting HPV infection and/or HPV-related disease at enrollment. Methods. Phase 3 effic

The neutrophil-mobilizing cytokine interleukin-26 in the airways of long-term tobacco smokers

Long-term tobacco smokers with chronic obstructive pulmonary disease (COPD) or chronic bronchitis display an excessive accumulation of neutrophils in the airways; an inflammation that responds poorly to established therapy. Thus, there is a need to identify new molecular targets for the development of effective therapy. Here, we hypothesized that the neutrophil-mobilizing cytokine interleukin (IL)

Over-expression, purification and characterization of a β-mannanase BoMan26B from Bacteroides ovatus

Hemicelluloses account for 25-30% of total wood dry weight. Mannan-based polysaccharides are the major component of softwood hemicelluloses. They are characterized by their β-1,4-glycosidic linked backbone composed of mannose or a combination of mannose and glucose residues. The backbone can be substituted by α-1,6-linked galactose residues. β-mannanases cleave the internal β-1,4-glycosidic bonds

Eotaxin-3 (CCL26) exerts innate host defense activities that are modulated by mast cell proteases

BackgroundDuring bacterial infections of the airways, a Th1-profiled inflammation promotes the production of several host defense proteins and peptides with antibacterial activities including -defensins, ELR-negative CXC chemokines, and the cathelicidin LL-37. These are downregulated by Th2 cytokines of the allergic response. Instead, the eosinophil-recruiting chemokines eotaxin-1/CCL11, eotaxin-2