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Persistent circulating tumor DNA (ctDNA) during neoadjuvant treatment (NAT) of early breast cancer (EBC) indicates high-risk disease. Similarly, detection of ctDNA post-resection indicates molecular residual disease (MRD) and impending relapse. For ctDNA to be integrated into EBC management, accessible and scalable diagnostics are required. Here we apply an ultrasensitive, personalized tumor-infor
Predicting Progression to Type 1 Diabetes from Ages 3 to 6 in Islet Autoantibody Positive TEDDY Children: Predicting Progression to T1D in TEDDY OR I G I N A L A R T I C L E Predicting progression to type 1 diabetes from ages 3 to 6 in islet autoantibody positive TEDDY children Laura M. Jacobsen1 | Helena E. Larsson2 | Roy N. Tamura3 | Kendra Vehik3 | Joanna Clasen3 | Jay Sosenko4 | William A. Hag
https://www.teddy.lu.se/sites/teddy.lu.se/files/05072019_679_102_mp62_jacobsen_peddiab_2019_0.pdf - 2026-07-20
Longitudinal Metabolome-Wide Signals Prior to the Appearance of a First Islet Autoantibody in Children Participating in the TEDDY Study Longitudinal Metabolome-Wide Signals Prior to the Appearance of a First Islet Autoantibody in Children Participating in the TEDDY Study Qian Li,1 Hemang Parikh,1 Martha D. Butterworth,1 Åke Lernmark,2 William Hagopian,3 Marian Rewers,4 Jin-Xiong She,5 Jorma Toppar
https://www.teddy.lu.se/sites/teddy.lu.se/files/117_mp224_li_et_al._metabolomics_diabetes.pdf - 2026-07-20
The term hybrid immunity is used to denote the immunological status of vaccinated individuals with a history of natural infection. Reports of new SARS-CoV-2 variants of concern motivate continuous rethought and renewal of COVID-19 vaccination programs. We used a naturalistic case-control study design to compare the effectiveness of the BNT162b2 mRNA vaccine to hybrid immunity 180 days post-vaccina
Purpose: To assess the association between cystatin C-derived estimates of kidney function and mortality and acute kidney injury (AKI) in sepsis. Materials and methods: Post-hoc analysis of sepsis patients in the FINNAKI-cohort (n = 802). Primary outcome was 90-day mortality. We measured plasma cystatin C and creatinine at intensive care unit (ICU) admission and estimated glomerular filtration rat
BACKGROUND: Engagement in activities meaningful to the individual may support the process of recovery in those with mental illness. Persons with psychiatric disabilities may reduce their engagement in meaningful activities to various degrees with possible fluctuations over time. We hypothesized that activity engagement can be altered when opportunities and support are offered at an individual and
The results of a search for vector-like top quarks using events with exactly one lepton, at least four jets, and large missing transverse momentum are reported. The search is optimised for pair production of vector-like top quarks in the Z() t + X decay channel. LHC pp collision data at a centre-of-mass energy of s=13 TeV recorded by the ATLAS detector in 2015 and 2016 are used, corresponding to a
Disengagement is a phenomenon that exists to some degree in all levels of education. Socio-psychological in nature, it manifests in a wide array of behaviours, from inactivity to disruptive behaviour. This thesis is an explorative and dialectical study of the methods and strategies used to engage disengaged students, focusing on the digital language classroom. Using qualitative research methods,
There is a need for more efficient measures to ensure responsible migration in host countries. Sports are recognised as a key measure to promote integration. This thesis’s purpose is to increase the understanding of the impacts football clubs have on integration for youth girls with foreign backgrounds in Stockholm, Sweden. This is done by exploring social relations’ role in integration and examin
Syftet med denna studie var att undersöka hur fitness influencers på plattformen Instagram använder sig av erfarenheter kring mental- och fysisk ohälsa för att skildra sig själva som autentiska individer. Dessa motgångar antogs leda till upprättandet av emotionella band med deras följare, och därmed ett stärkande av influencernas varumärkesidentiteter. Tidigare forskning visar att autenticitet spe
Along with the rapid development of investment and trade in the context of economic globalisation, a number of legal issues, risks and disputes related to the essential security exception have gradually emerged in the field of international investment. Although contracting states have consciously agreed on essential security exception regulations in the international investment system, the provisi
The formation of industry standards for environmental issues and corporate social responsibility is gaining acceptance but the number of successfully implemented programs are few. On an individual level companies have for some time applied company standards or codes of conduct. But on a collective level cooperation seems much more difficult. Although from an economic point of view there are clear
This thesis aims to look into how some social workers in Sweden view their work with youths having sex for compensation with regards to the feminist ideas that the law on buying sex expresses. Swedish studies have shown that most of the youths having sex for compensation started when they were 13-14 years old. Previous literature and studies state that youths having sex for compensation often have
The anticipated climate changes are predicted to alter the precipitation patterns in Sweden. Increased episodes of intense short-duration rainfall and higher intensities of day long-duration rainfall are expected. Road sections are often a target of flooding, causing impassable roads, due to the lack of capacity of drainage systems. One of the factors determining the water flow to a depression is
Results are presented of a search for particles decaying into final states with significant missing transverse momentum and exactly two identical flavour leptons (e, mu) of opposite charge in root s = 7 TeV collisions at the Large Hadron Collider. This channel is particularly sensitive to supersymmetric particle cascade decays producing flavour correlated lepton pairs. Flavour uncorrelated backgro
A search has been performed for the experimental signature of an isolated photon with high transverse momentum, at least one jet identified as originating from a bottom quark, and high missing transverse momentum. Such a final state may originate from supersymmetric models with gauge-mediated supersymmetry breaking in events in which one of a pair of higgsino-like neutralinos decays into a photon
A search for the direct production of charginos and neutralinos in final states with three electrons or muons and missing transverse momentum is presented. The analysis is based on 4.7 fb(-1) of root s = 7 TeV proton-proton collision data delivered by the Large Hadron Collider and recorded with the ATLAS detector. Observations are consistent with Standard Model expectations in three signal regions
The thesis aims at supplementing a critique of the existing international instruments, regional responses and national legislation of the Arctic related to marine environmental protection. With this aim in view, the thesis satisfies its objective by proposing a Bipartite “Arctic Council” acting as a conglomeration of the Arctic States and the Flag States with a hybrid “Arctic treaty”, which is an
Purpose: To analyse characteristics from the SMR to explore the risk factors for visual acuity (VA) below ≤ 35 letters of the Early Treatment Diabetic Retinopathy Study (ETDRS) due to nAMD during a two-year follow-up. Methods: This study evaluates 6142 treatment-naïve eyes, with focus on a subgroup of 780 eyes with final VA outcome of ≤ 35 letters, regarding differences of baseline characteristics
Introduction: Lower limb revascularization with inguinal incisions is a common vascular surgical procedure. Due to risk of injury to lymphatic vessels and a diverse bacterial flora in the groin, surgical site infections (SSI) represent a common and sometimes life-threatening complication. While transverse incisions in endovascular aneurysm repair has a low SSI rate, vertical incisions in thrombend
