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IntroductionHealth-related quality of life (HRQoL) is essential for human wellbeing, influenced by a complex interplay of factors, and is reported lower in women than men. We aimed to evaluate which factors were the most important for HRQoL in a middle-aged general population.MethodsThis was a cross-sectional, multi-centre study of 29,212 men (48%) and women (52%) aged 50–64 in the general populat
The accumulation of senescent cells drives inflammaging and increases morbidity of chronic inflammatory lung diseases. Immune responses are built upon dynamic changes in cell metabolism that supply energy and substrates for cell proliferation, differentiation, and activation. Metabolic changes imposed by environmental stress and inflammation on immune cells and tissue microenvironment are thus chi
Purpose of Review: Despite no general conclusions regarding the therapeutic effect of MSCs on virus-induced acute lung injury in pre-clinical studies, a significant number of clinical trials using MSC-based treatment for COVID-19-associated ARDS were initiated during the global pandemic. Here, we aimed to discuss differences and similarities in clinical trials using MSC-based treatments for classi
Objective: To identify and quantify potential risk factors for osteoarthritis (OA) following traumatic knee injury. Design: Systematic review and meta-analyses that estimated the odds of OA for individual risk factors assessed in more than four studies using random-effects models. Remaining risk factors underwent semiquantitative synthesis. The modified GRADE (Grading of Recommendations Assessment
Paleoklimatologi – läran om hur klimatet utvecklats genom jordens historia – ger oss referensramar för att sätta dagens klimat och möjliga framtida klimatförändringar i ett historiskt perspektiv. Till exempel visar nya analyser av historiska klimatarkiv att för norra halvklotet var perioden 1983-2012 sannolikt den varmaste på 1400 år. Vi ser även att vid den senaste värmeperioden, för 125 000 år s
Background: Obstetrical anal sphincter injuries are complications of vaginal birth that have the potential to cause substantial maternal morbidity. Predicting these injuries might help to improve maternal care as well as antenatal counseling and patient education. Previous attempts to create prediction models have in many cases involved variables only known postpartum, which limits their use in an
Introduction: Most centers treating patients with anorectal malformation (ARM) will screen for anomalies of the kidneys and urinary tract by using ultrasonography. There is no consensus on whether screening for vesico-ureteral reflux (VUR) should occur. To meet the diagnostic needs of ARM patients a method was developed to include a simultaneous VUR diagnosis and pre-reconstructive fistula work-up
Context: Medications may become inappropriate for patients in the last phase of life and may even compromise their quality of life. Objective: To find consensus on recommendations regarding deprescribing of medications for adult patients with a life expectancy of six months or less. Methods: Experts working in palliative care or other relevant disciplines were asked to participate in this internat
From newly obtained high-resolution, high signal-to-noise ratio spectra the abundances of the elements La and Eu have been determined over the stellar metallicity range -3<[Fe/H]<+0.3 in 159 giant and dwarf stars. Lanthanum is predominantly made by the s-process in the solar system, while Eu owes most of its solar system abundance to the r-process. The changing ratio of these elements in stars ove
Knowledge of the neutron light-yield response is crucial to the understanding of scintillator-based neutron detectors. In this work, neutrons from 2–6 MeV have been used to study the scintillation light-yield response of the liquid scintillators NE 213A, EJ 305, EJ 331 and EJ 321P using event-by-event waveform digitization. Energy calibration was performed using a GEANT4 model to locate the edge p
In recent years, researchers worldwide have become increasingly interested in the phenomenon of code-switching in the multilingual classroom. The paper aims to try to understand when and why teachers in Swedish for Immigrants (SFI) schools code-switch in their classrooms. It analyses the methods and reasons for teachers’ code-switching in the SFI classroom. A case study was conducted by means of a
Occlusion is the most common reason for lowered recognition yield in free-flow license-plate reading systems. (Non-)occluded characters can readily be learned in separate neural networks but not together. Even a small proportion of occluded characters in the training set will already significantly reduce the overall recognition yield. This paper shows that a modular network can handle a realistic
The article reports on a longitudinal study of children placed in a children's home during the first two years of the 1980s. The 26 children placed when younger than 4 years of age and staying more than 4 weeks were followed up 3 and 9 months after leaving the children's home and 5, 10, 15 and 20 years later. The children's family relations, including early attachments and later parental relations
Using restriction fragment length polymorphism (RFLP) we identified 26 unique major histocompatibility complex (MHC) genotypes in 104 water pythons. We observed a significant independent association between reduced blood parasite load (Hepatozoon sp.) and python body length/age, presence of a specific RFLP fragment (C-fragment) and the overall number of fragments. The parasite has a negative impac
Increased QT dispersion and loss of sinus rhythm were both associated with sudden cardiac death in patients with transposition of the great arteries after Mustard and Senning operations at the early and late postoperative periods. A combination of increased QT dispersion with loss of sinus rhythm increases the positive predictive value for sudden cardiac death in patients with transposition of the
Popular Abstract in Swedish Framtida klimatförändringar påverkas till stor del på människans utsläpp av CO2, samt av klimat- och CO2-relaterade återkopplingar genom kolcykeln i både landbaserade ekosystem och hav. Landbaserade ekosystem tar för tillfället upp omkring 25% av de antropogena utsläppen av CO2 från förbränning av fossila bränslen och markanvändning, men att tillskriva vilka mekanismer The nature of future climate change will depend on anthropogenic emissions of CO2, as well as climate- and CO2-mediated feedbacks through carbon (C) cycling in both terrestrial ecosystems and oceans. Terrestrial ecosystems remove presently about 25% of the anthropogenic CO2 fossil-fuel and land-use change emissions, but to attribute which mechanisms cause this uptake, and the key regions where it
These guidelines are for practicing orthopedic surgeons who do not have a special interest in treatment of osteoporosis or prevention of falls, but who should have basic knowledge about how to prevent new fractures.
