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Recent observations of the gamma-ray source HAWC J2227+610 by Tibet AS+MD and LHAASO confirm the special interest of this source as a galactic PeVatron candidate in the northern hemisphere. HAWC J2227+610 emits Very High Energy (VHE) gamma-rays up to 500 TeV, from a region coincident with molecular clouds and significantly displaced from the nearby pulsar J2229+6114. Even if this morphology favour

Our global sustainability challenges are complex and require partnerships and collaboration across disciplines and sectors. As such, as a society, we must value interdisciplinary perspectives and work together to address these challenges. In this episode, we discuss the value of interdisciplinary education to address our complex sustainability challenges. We share the experience from our two inter

Cross-sectional studies of growth in post-colonial Africa have overwhelmingly focussed on explaining the failure of growth in Africa. This prompting stylised fact has its qualifications and when these are taken into consideration the explanations of African economic growth appear incoherent. The notion of a chronic African growth failure has diverted attention from the process of economic growth a

Secondary metabolites from fungi have become a major source of chemical innovation in programs searching for lead molecules with bioactivities, especially over the last 50 years. In this review, we discuss the fundamental considerations in the discovery of molecules for agricultural and medicinal uses. This group of organisms possesses a strong potential for scientific and industrial communities.

We can trace the beginnings of our knowledge of early Upper Paleolithic (Aurignacian) use of fire to the pioneering 1910–1911 excavations at Abri Blanchard undertaken by Louis Didon and Marcel Castanet. At Blanchard, the excavators recognized and described fire structures that correspond in many ways to features excavated more recently in Western and Central Europe. Here, we address the issue of h

The Just-in-Time production system, or lean production system, tries to achieve a continuous flow of production, thereby reducing the inventories of materials, works-in- process and finished products. As a result only minimum levels of inventories exist in the various layers of the supply chain. Under this situation, the major earthquake followed by the tsunami on March 11, 2011 in Eastern Japan,

This thesis is a study of social life, addressing issues concerning how and by what means people meet in urban public space. The main aim of this thesis is to is to investigate how certain artefacts and architectural features support the formation and temporal stabilisation of heterogeneous clusters and collectives, and thus, in order to the development of conceptual tools that can contribute to a

Pulmonary diseases are known to be largely inhomogeneous. To evaluate such inhomogeneities, we are testing an image-based method to measure gas flow in the lung regionally. Dynamic, spin-density-weighted hyperpolarized (3)He MR images performed during slow inhalation of this gas were analyzed to quantify regional inflation rate. This parameter was measured in regions of interest (ROIs) that were d

p90 ribosomal S6 kinases (RSKs) respond to various mitogen stimuli and comprise two distinct protein kinase domains. The C-terminal kinase domain (CTKD) receives signal from ERK1/2 and adopts an autoinhibitory mechanism. Here, the crystal structure of human RSK1 CTKD is reported at 2.7 Å resolution. The structure shows a standard kinase fold, with the catalytic residues in the ATP-binding cleft or

In this paper the Poisson bracket algebra for the open massless relativistic string in the one-space-and one-time-dimensional case is considered. In order to characterize the orbit of the system the directrix function, i.e., the orbit of one of the endpoints of the string, is used. It turns out that the Poisson bracket algebra is of a very simple form in terms of the parameters of the directrix fu

This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: The objective of this review is to assess benefits and harms of non-invasive respiratory support for themanagement of transient tachypnea of the newborn.

This chapter is a micro-sociological exploration of the justifications that Danish general practitioners adopt to support antibiotic usage in their clinical practices. Based on qualitative in-depth interviews with 21 general practitioners in Denmark, the chapter looks upon the clinic as a particular social world (a justificatory regime) in which different antibiotic treatment strategies are qualif

The invention relates to a method of 13C-MR detection using an imaging medium comprising hyperpolarised 13C-lactate and to an imaging medium containing hyperpolarised 13C1-lactate for use in said method.

Visual abilities of the honey bee have been studied for more than 100 years, recently revealing unexpectedly sophisticated cognitive skills rivalling those of vertebrates. However, the physiological limits of the honey bee eye have been largely unaddressed and only studied in an unnatural, dark state. Using a bright display and intracellular recordings, we here systematically investigated the angu