The Design and Structure Prediction of Protein Oligomers
The minimum free energy state of a protein (the native state) is encoded by its amino-acid sequence. Due to the many torsional degrees of freedom (DOF) available to a polypeptide chain, a vast number of conformations is possible. Therefore, to predict the native state of a protein directly from sequence, a computer algorithm must evaluate a large number of possible conformations using accurate sco
