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Tissue factor (TF)-mediated protease activated receptor (PAR)-2 signaling is associated with a pro-migratory, invasive and pro-angiogenic phenotype in experimental models of breast cancer, and has been mechanistically coupled to phosphorylation of the TF cytoplasmic domain (pTF). However, the clinical relevance of these findings are unknown. Here, we provide first in vivo evidence of TF phosphoryl
The Lecanoromycetes is the largest class of lichenized Fungi, and one of the most species-rich classes in the kingdom. Here we provide a multigene phylogenetic synthesis (using three ribosomal RNA-coding and two protein-coding genes) of the Lecanoromycetes based on 635 newly generated and 3307 publicly available sequences representing 1139 taxa, 317 genera, 66 families, 17 orders and five subclass
An accurate molecular diagnosis of diabetes subtype confers clinical benefits; however, many individuals with monogenic diabetes remain undiagnosed. Biomarkers could help to prioritise patients for genetic investigation. We recently demonstrated that high-sensitivity C-reactive protein (hsCRP) levels are lower in UK patients with hepatocyte nuclear factor 1 alpha (HNF1A)-MODY than in other diabete
Purpose. The overall purpose was to study whether and how persons with blindness detect warning surfaces with a long white cane in a real pedestrian environment after following a natural guidance surface to the warning surfaces. Of particular interest was the importance of kerb, depth, and structure of the warning surfaces. Method. A concurrently mixed methods approach, with a combination of obser
This Letter presents a search for pair production of heavy down-type quarks decaying via b' -> Wt in the lepton + jets channel, as b'(b) over bar' -> W(-)tW(+)(t) over bar -> b (b) over barW(+)W(-)W(+)W- -> l(+/-) nu b (b) over barq (q) over barq (q) over barq ($) over barq. In addition to requiring exactly one lepton, large missing transverse momentum, and at least six jets, the invariant mass of
Measurements of fiducial and differential cross sections are presented for Higgs boson production in proton-proton collisions at a centre-of-mass energy of TeV. The analysis is performed in the H -> gamma gamma decay channel using 20.3 fb(-1) of data recorded by the ATLAS experiment at the CERN Large Hadron Collider. The signal is extracted using a fit to the diphoton invariant mass spectrum assum
Maternal mortality levels in most low middle income countries is not been the same over the past decades. Among these countries, some of them seem to have an improvement in reducing maternal mortality but the aggregate picture is indicated the regional progress as not that impressive. This is been the case because of the different social and economic policies that each low-middle income countries
This master thesis presents a framework, aimed at assessing fire risk in large automated warehouses. The International Electrotechnical Commission’s (IEC) framework, Risk analysis of technological systems, provides the base, as to the functions of a risk analysis framework and this is subsequently adopted and expanded to better suit the fire risk analysis in high-bay warehouses. The framework pres
This thesis discusses ethical consumption with a focus on individual’s identity, the notion of reflexivity and the importance of information in being an ethical consumer in a globalized world. The concepts of reflexivity, habitus, self- and social identities are reviewed. Using hermeneutic approach to analysis of in-depth semi-structured interviews of individuals who identify themselves as ethical
Joint Operations at the external borders of the EU are axiomatic for EU’s border management policy and constitute forms of collective action involving the efforts of two or more Member States for the purpose of securing the common borders. Nevertheless, participation in joint operations is based on voluntarism and guided by the principle of solidarity, which should act as catalysts encouraging MSs
Despite longstanding and far-reaching recognition of the need for social change towards environmental sustainability, the delivery of this transition is proving problematic. Dominant strategies for sustainable development in western countries focus on uncoupling economic development from ecological harm. Scandinavia epitomises this approach to green economy, especially in the transition to a low-c
Rivers have been modified significantly during the last 200 years in Switzerland. These modifications were done for protection purposes (protection against floods), construction of hydropower plants, gain of land or other human activities. These artificial transformations have reduced, sometimes drastically, the natural dynamic of the rivers, which has reduced biodiversity, and has also increased
The greater wax moth, Galleria mellonella, is a serious pest of honey bees, Apis mellifera, damaging the quality of honey produced and creating a problem for bee industry. Mating behaviour in this species takes place with the help of a male-released pheromone tracked by females over long distances. Previously, the male pheromone was identified to be a blend of nonanal and undecanal but this aldehy
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Regelverk på nationell och internationell nivå som syftar till att uppmuntra och underlätta internationella investeringar och handel möjliggör idag för multinationella företag att verka transnationellt genom användning av filialer och dotterbolag. När det kommer till företagsbeskattning har avsaknaden av ett globalt och universellt skattesystem för att reglera internationella skattefrågor dock möjDomestic and international regulations aiming to facilitate international trade and investment today enable multinational corporations (MNCs) to operate transnationally through the use of branches or subsidiary companies. Within the field of corporate taxation, the lack of a global and universal tax system regulating international tax matters however allows MNCs to exploit gaps and loopholes withi
In modern history, Sweden has experienced two major financial crises: the early 1990s and the global financial crisis in 2008. During the last decades, there has been an increased global focus on regulating and supervising banks, where Basel III is the leading framework. Today, one of the most debated issues within the global economy is Covid-19. It is uncertain how the pandemic will affect countr
Transgender persons experience a disproportionate representation in adverse mental health conditions globally. In Sweden there are tangible efforts to improving mental healthcare overall, but as a minority population, transgender persons still struggle with meeting their mental healthcare needs. While social factors such as stigma and discrimination act as catalysts for this burden, there is an ab
Urban green infrastructure (UGI) is gaining popularity for disaster risk reduction and climate change adaptation in urban contexts, but dense development obstructs the realisation of large-scale greening measures. This thesis investigates the potential of small-scale, site-specific urban greening in a residential area in Cologne, Germany, to improve ecosystem service supply. The objective is to as
This thesis aims to investigate the newly emerging phenomenon in the environmental justice sphere – namely, the weaponisation of art by climate activists for the purpose of attracting attention to specific demands held. These attacks materialise in the form of organised acts wherein tactics entailing vandalism are enacted by a climate activist group. With the commencement of this climate movement
The biomedical market is experiencing rapid growth, driven by the increasing volume of health data and the need for advanced technologies to manage and analyze this information. At the same time, the industry is facing additional challenges such as the shortage of healthcare professionals and an aging population. Artificial intelligence (AI) has the potential to become essential in this industry,
