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PURPOSE: Filter exchange imaging (FEXI) is sensitive to the rate of diffusional water exchange, which depends, eg, on the cell membrane permeability. The aim was to optimize and analyze the ability of FEXI to infer differences in the apparent exchange rate (AXR) in the brain between two populations.METHODS: A FEXI protocol was optimized for minimal measurement variance in the AXR. The AXR variance
Although the repair of ventral abdominal wall hernias is one of the most commonly performed operations, many aspects of their treatment are still under debate or poorly studied. In addition, there is a lack of good definitions and classifications that make the evaluation of studies and meta-analyses in this field of surgery difficult. Under the auspices of the board of the European Hernia Society
We derive a gap equation for bilayer excitonic systems based on density functional theory and benchmark our results against quantum Monte Carlo simulations and recent experiments on double bilayer graphene. The gap equation has a mean-field form but includes a consistent treatment of dynamical screening. We show that the gap survives at much higher densities than previously thought from mean-field
Objective To evaluate the effectiveness of oral glucosamine in subgroups of people with hip or knee osteoarthritis (OA) based on baseline pain severity, body mass index (BMI), sex, structural abnormalities and presence of inflammation using individual patient data. Methods After a systematic search of the literature and clinical trial registries, all randomised controlled trials (RCTs) evaluating
Geocoding longitudinal and individual-level historical demographic databases enables novel analyses of how micro-level geographic factors affected demographic outcomes over long periods. However, such detailed geocoding involves high costs. Additionally, the high spatial resolution cannot be properly utilized if inappropriate methods are used to quantify the geographic factors. We assess how diffe
The issue of corporate accountability for human rights has gained significant attention in recent years, driven by increasing globalisation, complex corporate structures, and the public’s growing awareness of the harmful effects of business activities. Alongside the rising prominence of human rights on the international agenda, the issue of environmental impacts of corporations has also become mor
Cash holding strategy is an important financial decision for firms. It is highly related to firms’ operation and development because cash is an important guarantee to meet the business payment and investment opportunity. However, some scholars believe that due to agency problems, too much cash holdings are likely to produce negative impact on enterprise value. Compared to listed firms on Chinese A
People’s ability to learn holds a promise for sustainability as learning is seen to enable change; yet, the prevalence of norms and values in society that reinforce unsustainability may severely challenge this process. The debate on what role learning can play is centered around the question whether people can learn from others and if so, how to enhance it. More precisely, who has to learn what fr
Examining the relation between Swedish households’ debt, property price and interest rates are important when forming monetary policy implications. Several studies have examined the driving factors of household debt and property price, however the results are inconclusive. This thesis differs from previous research as it includes the variable interest to income ratio, instead of debt ratio, as the
Bumblebees and other pollinators are important contributors to the ecosystem service of pollination of wild plants and crops. As in many pollinating insects, their abundance and diversity have declined in recent years, due to loss of natural habitats and fragmentation associated with urbanization and agricultural intensification. However, in urban areas, green space management beneficial to pollin
The present thesis explores the requirement of the waiting period to grant family reunification to Third Country Nationals from the perspective of human rights law. It examines how this requirement, which currently forms a significant part of immigration policies within European member states, may impact TCNs' Right to family life under the European Convention on Human Rights (ECHR) and EU
Access to water is taken for granted in water abundant countries like Sweden, but safe water supply is increasingly threatened by droughts. This thesis analyses how the Swedish water sector responded to the unprecedented drought in 2018, by analysing water security discourse through the framework “What’s the problem represented to be?”. It explores implications of the drought on water policy and h
The recent advent of 3DSG in the computer vision domain has brought powerful high-level representations of 3D environments. These representations strive to mimic human perception and facilitate the extraction of meaningful insight from visual data. This research has led to framework like Hydra, which creates a real-time, persistent spatial perception system that creates a complete 3D map of their
The objective of this report is twofold: to optimise the extraction method of lignin from spruce altering a few process parameters and to investigate the use of lignin as a hydrophobic barrier in food applications. The process used was STEX (steam explosion) pretreatment followed by enzymatic hydrolysis and MWL (milled wood lignin) extraction using a mixture of dioxane-water. The lignin was then c
This thesis poses structural and behavioural competition problems in digital markets in terms of core platforms services provided by the gatekeepers under the proposed Digital Markets Act by the European Commission, where such problems are the most evident. This thesis analyses whether existing competition and more sector-specific legal tools are functional to address these problems. Traditional l
BACKGROUND AND AIMS: Autoantibodies against the zinc transporter 8 (ZnT8A) are common in type 1 diabetes (T1D). ZnT8A analyses are complicated by the fact that there are three variants of the autoantigen at amino acid position 325 representing ZnT8-R (Arginine), ZnT8-W (Tryptophan) and ZnT8-Q (Glutamin). The aims of the study were: 1) to develop an autoantigen triple mix Radio-Binding Assay (RBA)
Susceptibility to osteoporotic fracture is influenced by genetic factors that can be dissected by whole-genome linkage analysis in experimental animal crosses. The aim of this study was to characterize quantitative trait loci (QTLs) for biomechanical and two-dimensional dual-energy X-ray absorptiometry (DXA) phenotypes in reciprocal F2 crosses between diabetic GK and normo-glycemic F344 rat strain
Since treatment for latent cryptococcal infection (CI) before starting antiretroviral therapy (ART) reduces mortality in HIV-infected subjects, screening for cryptococcal antigen (CrAg) in blood is recommended for individuals with CD4 cell counts < 100 cells/µL in regions with high CI prevalence. We assessed CrAg screening using the lateral flow assay in HIV-infected adults eligible for ART in cen
Aim. The aim of this study is to examine associations between caregiver burden, perceived health and sense of coherence in family caregivers to persons with dementia living at home. Background. Most of the studies on family caregivers have focused on burden and morbidity. However, the caregiver's sense of coherence and perceived health have not been studied earlier in relation to caregiver burden.
