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Aviation is a highly inter-connected system. This means that a problem in one area may cause effects in other countries or parts of the Air Transport System (ATS). Examples range from local air traffic disruptions to the 2010 volcanic ash crisis. Agility, like resilience, refers to the ability to cope with dynamics and complexity in a flexible manner, by adjusting and adapting performance and the

Aim: In neuroendocrine cells, large dense-core vesicles (LDCVs) undergo highly regulated pre-fusion processes before releasing hormones via membrane fusion. Significant heterogeneity has been found for LDCV population based on the dynamics of membrane fusion. However, how the pre-fusion status impacts the heterogeneity of LDCVs still remains unclear. Hence, we explored pre-fusion determinants of h

Here we present a new eastern Baltic Chironomidae training set (TS) containing 35 sites that was collected and merged with neighbouring published Finnish (82 lakes) and northern part of the Polish (nine lakes) TSs. Chironomidae, non-biting midges, are known to be strongly responsive to the July air temperature and are widely used to infer palaeotemperature. Several modern analogue-based TSs necess

Winter warming events (WWEs) are short-lasting events of unusually warm weather, occasionally combined with rainfall, which can cause severe ecosystem impacts by altering ground temperatures and water fluxes. Despite their importance, how large-scale ecosystem models perform in depicting the impacts of WWEs remain largely unknown. The frequency and intensity of WWEs will likely increase further in

We give a complete proof of the classical Benjamin and Lighthill conjecture for arbitrary two-dimensional steady water waves with vorticity. We show that the flow force constant of an arbitrary smooth solution is bounded by the flow force constants for the corresponding conjugate laminar flows. We prove these inequalities without any assumptions on the geometry of the surface profile and put no re

Background: Chronic lung disease (CLD) occurs frequently in preterm infants and is associated with respiratory morbidity. Bronchodilators have the potential effect of dilating small airways with muscle hypertrophy. Increased compliance and tidal volume, and decreased airway resistance, have been documented with the use of bronchodilators in infants with CLD. Therefore, bronchodilators are widely c

Heart failure (HF) is a leading cause of death and disability globally. HF represents the common end- stage of most heart conditions, during which the heart is unable to generate sufficient output of blood for the metabolic demands of the body and intracardiac pressures increase. Different heart diseases display specific molecular pathophysiologies, but common pathways are also present that drive

During the last decade, the application of strontium isotope analysis (87Sr/86Sr) has increased rapidly. The understanding of the strontium isoscape and the construction of a strontium isotope baseline in southern Scandinavia are biased toward Denmark and southwestern to eastern Scania. We report the results of new baseline samples in Halland and the Bjäre Peninsula, adding to the rich strontium i

A search for the associated production of a heavy resonance with a top-quark or a top-antitop-quark pair, and decaying into a tt¯ pair is presented. The search uses the data recorded by the ATLAS detector in pp collisions at s=13 TeV at the Large Hadron Collider during the years 2015–2018, corresponding to an integrated luminosity of 139 fb-1. Events containing exactly one electron or muon are sel

The nature of work has already, for some time, been undergoing major changes as a result of technological progress. Mobile, virtual and cloud technologies, and the infrastructures that support them, are increasingly enabling work to be done from anywhere and at any time. The COVID-19 pandemic has further accelerated this process, driving a large share of white-collar knowledge work to remote and h

Evacuation models commonly employ pseudorandom sampling from distributions to represent the variability of human behaviour in the evacuation process, otherwise referred to as ‘behavioural uncertainty’. This paper presents a method based on functional analysis and inferential statistics to study the convergence of probabilistic evacuation model results to inform deciding how many repeat simulation

We study the homogenization of the Dirichlet problem for the Stokes equations in R3 perforated by m spherical particles. We assume the positions and velocities of the particles to be identically and independently distributed random variables. In the critical regime, when the radii of the particles are of order m-1, the homogenization limit u is given as the solution to the Brinkman equations. We p

The trigeminal system is key to the pathophysiology of migraine and cluster headache, two primary headache disorders that share many features. Recently, MER proto-oncogene tyrosine kinase (MERTK), a cell surface receptor, was strongly associated with cluster headache through genetic studies. Further, the MERTK ligand galectin-3 has been found to be elevated in serum of migraine patients. In this s

Liskov, Rivest and Wagner laid the theoretical foundations for tweakable block ciphers (TBC). In a seminal paper, they proposed two (up to) birthday-bound secure design strategies — LRW1 and LRW2  — to convert any block cipher into a TBC. Several of the follow-up works consider cascading of LRW-type TBCs to construct beyond-the-birthday bound (BBB) secure TBCs. Landecker et al. demonstrated that j

The suitability of Hansen solubility parameters as descriptors for modelling analyte retention during reversed-phase chromatographic experiments was investigated. A novel theoretical model using Hansen solubility parameters as the basis for a complete mathematical derivation of the model was developed. The theoretical model also includes the cavitation volumes of the analytes, which were calculate

Aftershock rates seem to follow a power law decay, but the assessment of the aftershock frequency immediately after an earthquake, as well as during the evolution of a seismic excitation remains a demand for the imminent seismic hazard. The purpose of this work is to study the temporal distribution of triggered earthquakes in short time scales following a strong event, and thus a multiple seismic