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Investigation of molecular alterations of AKT-3 in triple-negative breast cancer

Aims Triple-negative breast cancer (TNBC) is responsible for a disproportionate number of breast cancer (BC) deaths, owing to its intrinsic aggressiveness and a lack of treatment options, especially targeted therapies. Thus, there is an urgent need for the development of better targeted treatments for TNBC. Molecular alteration of AKT-3 was previously reported in oestrogen receptor (ER)-positive B

Increased arterial stiffness in women, but not in men, with IDDM

For unknown reasons, there is a greater increase in the risk for cardiovascular complications in diabetic women than in diabetic men. Our aim was to study gender-related differences in the mechanical properties of the great arteries in patients with insulin-dependent diabetes mellitus (IDDM) but free from known cardiovascular and cerebrovascular complications. We measured arterial stiffness (beta,

Cone-beam computed tomography, a new low-dose three-dimensional imaging technique for assessment of bone erosions in rheumatoid arthritis : reliability assessment and comparison with conventional radiography – a BARFOT study

Objectives: To determine the intra- and inter-observer agreement of erosions detected and scored with cone-beam computed tomography (CBCT) of bones in the hands and feet, and to compare CBCT with conventional radiography (CR) for assessment of bone erosions in patients with long-standing rheumatoid arthritis (RA). Method: Thirty patients with long-standing RA from the Better Anti-Rheumatic Pharmac

Enhancement of anaerobic batch digestion of sisal pulp waste by mesophilic aerobic pre-treatment

Pre-treatment of sisal pulp prior to its anaerobic digestion was investigated using an activated sludge mixed culture under aerobic conditions in batch bioreactors at 37 degrees C. The progression of aerobic pre-treatment of the residue in relation to the activities of some extracellular hydrolytic enzymes in the slurry was monitored. The highest activity of hydrolytic enzymes was obtained at 9 h

Effects of phasic and tonic activation on contraction dynamics in smooth muscle

Responses to isotonic quick releases of rabbit urinary bladder strips and rat portal veins activated by AC-stimulation and K+-high medium were studied. The AC stimulation was adjusted to give the same tension as th K+-contractures. Releases were performed at peak of the contractions (which was attained after 1.5-4.5 s AC-stimulation or 2-3 min in K+-high solution). The length response consisted of

Massive MIMO Channel Modeling

Massive MIMO has attracted many researchers’ attention as it is a promising technology for future 5G communication systems. To characterize the propagation channels of the massive MIMO and to evaluate system performance, it is important to develop an accurate channel model for it. In this thesis, two correlative models, i.e., the Kronecker model and the Weichselberger model, and a cluster-based m

Current voltage characterization of high-k oxide on InGaAs substrate

Abstract Metal oxide semiconductor (MOS) capacitor was fabricated on the InGaAs substrate with Al2O3/HfO2 gate oxide. InGaAs is one of the promising candidates for advanced applications which require the lower power supply and high frequency. The high-k films (Al2O3/HfO2) were formed by atomic layer deposition (ALD) as an alternative to silicon dioxide (SiO2) to proceed the scaling of oxide to low

Barnen från S:t Jakob: tolkning av socioekonomisk kontext utifrån en osteologisk analys av S:t Jakob i Lund

S:t Jacobs church and burial site from medieval Lund was excavated in 1983. There has until now not been any osteological study and there is nearly no information about the church. To gain more information about the church and the burials, an osteological study has now been made. The analysis is based on aging and sexing the skeletons to enable a socio-economic discussion. 93 out of 320 excavated

Assessment of drift in the Immunotechnology cell line MUTZ-3

Analys av immunteknologis MUTZ-3 visar tecken på genetisk drift Allergi är en vanligt förekommande sjukdom som drabbar en stor del av befolkningen. Sjukdomen kan ta många olika former och vanliga typer är matallergi, luftvägsallergi och kontaktallergi. Kontaktallergi uppstår när en person kommer i upprepad kontakt med kemikalier som kan aktivera immunförvaret. Immunförsvarets är ett komplext nätveThe continued increased exposure to chemicals and the increasing prevalence of allergic contact dermatitis makes it important to develop accurate testing methods and strategies to assess chemical sensitizers. The Genomic Allergen Rapid Detection (GARD) assay is an in vitro test method that uses the transcriptional response of a myeloid cell line, MUTZ-3, after exposure to test substances to assess

Downscaling and modelling of an ion-exchange chromatography column for purifying glucose solutions

Skalning och modellering av en kromatografikolonn för rening av sockerlösningar. För att uppnå klimatmålen behöver fossila råvaror inom kemiindustrin bytas ut mot förnybara råvaror. Socker är en råvara med stor potential inom industrin, men är ofta förorenat med salter. Därför utforskas rening av sockerlösningar här. För att använda socker som förnybar råvara för kemiindustri behöver sockret oftaTo utilize sugars as a feedstock for renewable industries, the feedstock often needs to be very pure. This is due to ionic species contaminating the sugar feedstock being potent catalyst poisons in many cases. To remove ionic species from the sugar feedstock, it is dissolved and purified using packed ion-exchange columns. In this report, a lab-scale setup of a large scale ion-exchange setup was co

Evaluation of the Potential Lactic Acid Bacteria (LAB) to Ferment Quinoa Milk

The study aimed at (a) investigated the ability of potential lactic acid bacteria (LAB) to ferment quinoa milk, and (b) formulating a method for producing fermented quinoa milk. To meet the objectives, Lactobacillus pentosus and Pediococcus pentosaceus two native bacterial strains were tested. Quinoa milk elaboration was optimized at laboratory scale by selecting an appropriate quinoa/water propor

Global growth and stagnation of nuclear power - A case of diffusion of a new energy technology in a heterogenous system

Reaching the targets of the Paris Agreement requires acceleration of low-carbon energy transitions. At the same time, it is not fully understood why some technologies spread more rapidly and widely than others. This thesis advances our understanding of the diffusion of large-scale low-carbon technologies by bridging technology diffusion studies and political economy of transitions. Through combini

Hälsa och kreativt organisationsklimat

The aim of our study was to examine the relationship between creativity and wellbeing. The material for our study has been gathered through a questionnaire with self-assessment at one of Scandinavia's largest companies in the hotel industry. The questionnaire consisted of The organisational questionnaire (GEFA) and The measurement of wellbeing. In the study 90 questionnaires was distributed in

Beta-microseminoprotein in serum correlates with the levels in seminal plasma of young, healthy males

Beta-microseminoprotein (MSP) is one of the most abundant proteins secreted by the prostate gland. Because MSP is also synthesized in nonreproductive organs, the establishment of a solid relationship between the levels of MSP in serum and semen is crucial for future studies connecting MSP with aging or diseases of the prostate gland. We developed a specific, competitive, europium-based immunoassay