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Continuous Regional Arterial Infusion with Fluorouracil and Octreotide Attenuates Severe Acute Pancreatitis in a Canine Model

Aim: To investigate the therapeutic effects of fluorouracil (5-Fu) and octreotide (Oct) continuous regional arterial infusion (CRAI,) alone or in combination, was administered in a canine model of severe acute pancreatitis (SAP). Materials and Methods: The animals were divided into five groups; group A (Sham), group B (SAP), group C (SAP and 5-Fu), group D (SAP and Oct), and group E (SAP and 5-Fu

Carbon isotope signature variability among cultured microalgae: Influence of species, nutrients and growth

In this study we have investigated whether the carbon isotopic signature differs between different groups and species of marine phytoplankton depending on growth phase, nutrient conditions and salinity. The 15 investigated algal species, representing the Bacillariophyceae, Chlorophyceae, Cryptophyceae, Cyanophyceae, Dinophyceae and Haptophyceae classes were grown in batch monocultures and analysed

Aerobic fitness in prepubertal children according to level of body fat

Aim: The purpose of this study was to investigate the relationship between maximum oxygen uptake (VO2PEAK) and body fat in young children on a population-based level. Methods: Participants were 586 children (311 boys and 275 girls) aged 6.8 +/- 0.4 years, recruited from a population-based cohort. VO2PEAK was measured by indirect calorimetry during a maximal exercise test. Percent body fat (BF%) wa

Geographic Origin as a Determinant of Carotid Artery Intima-Media Thickness and Brachial Artery Flow-Mediated Dilation. The Cardiovascular Risk in Young Finns Study.

Objective - People living in eastern Finland have approximate to 40% higher coronary heart disease mortality rates than western Finns. Whether this is because of genetic or environmental factors is unknown. We examined the effect of geographic family origin on subclinical atherosclerosis among young Finns. Methods and Results - As part of a longitudinal follow-up study, we measured carotid intima-

Hepatocellular and extrahepatic cancer in patients with autoimmune hepatitis - a long-term follow-up study in 634 Swedish patients

Objectives. Cirrhosis is a well-known risk factor for hepatocellular cancer, but the true risk in autoimmune hepatitis (AIH) is scarcely studied. Other cancers may arise after prolonged use of immune-modulating drugs. The aim of this study was to investigate the cancer risk in a large cohort of AIH patients. Material and methods. Six hundred and thirty-four Swedish patients in a well-defined cohor

Institutional trust and alcohol consumption in Sweden: The Swedish National Public Health Survey 2006

Background: Trust as a measure of social capital has been documented to be associated with health. Mediating factors for this association are not well investigated. Harmful alcohol consumption is believed to be one of the mediating factors. We hypothesized that low social capital defined as low institutional trust is associated with harmful alcohol consumption. Methods: Data from the 2006 Swedish

Massive MIMO performance evaluation based on measured propagation data

Massive MIMO, also known as very-large MIMO or large-scale antenna systems, is a new technique that potentially can offer large network capacities in multi-user scenarios. With a massive MIMO system, we consider the case where a base station equipped with a large number of antenna elements simultaneously serves multiple single-antenna users in the same time-frequency resource. So far, investigatio

Examestane in advanced or recurrent endometrial carcinoma: a prospective phase II study by the Nordic Society of Gynecologic Oncology (NSGO)

Background: We evaluated the efficacy and safety of the aromatase inhibitor exemestane in patients with advanced, persistent or recurrent endometrial carcinoma. Methods: We performed an open-label one-arm, two-stage, phase II study of 25 mg of oral exemestane in 51 patients with advanced (FIGO stage III-IV) or relapsed endometrioid endometrial cancer. Patients were stratified into subsets of estro

Prevalence of thyroid autoimmunity in children with celiac disease compared to healthy 12-year olds.

Objectives. Studies have suggested a correlation between untreated celiac disease and risk for other autoimmune diseases. We investigated the prevalence of thyroid autoimmunity in 12-year-old children (i) with symptomatic celiac disease diagnosed and treated with a gluten-free diet, (ii) with screening-detected untreated celiac disease, and (iii) without celiac disease. Methods. Blood samples from

Sunnybrook and House-Brackmann Systems in 5397 Facial Gradings

Objectives. To study the correlation between Sunnybrook and House-Brackmann facial grading systems at different time points during the course of peripheral facial palsy. Study Design. Prospective multicenter trial. Setting. Seventeen otorhinolaryngological centers. Subjects and Methods. Data are part of the Scandinavian Bell's palsy study. The facial function of 1920 patients with peripheral facia

Co-adsorption of cadmium(II) and glyphosate at the water-manganite (gamma-MnOOH) interface

The co-adsorption of Cd(II) and glyphosate (N-(phosphonomethyl)glycine, PMG) at the manganite (gamma-MnOOH) surface has been studied in the pH range 6-10 at 25 degrees C and with 0.1 M Na(Cl) as ionic medium. Batch adsorption experiments, Fourier transform infrared spectroscopy (FTIR), X-ray photoelectron spectroscopy (XPS) and extended X-ray absorption fine Structure (EXAFS) spectroscopy were use

Practice patterns in haemophilia A therapy - global progress towards optimal care

This paper reports the findings of a global survey of practice patterns for the management of patients with haemophilia A. A total of 147 haemophilia treatment centres worldwide responded to the questionnaire, supplying data for 16 115 patients with haemophilia A. From these responses, 38% (range: 25-48%) of patients were under 18 years old. Almost half (47%) of patients were reported to have mild

Assessment of QT-measurement accuracy using the 12-lead electrocardiogram derived from EASI leads

The purpose of the present study is to assess QT-interval measurements from the EASI 12-lead electrocardiogram (ECG) as compared with the standard 12-lead ECG. The QT interval was automatically determined in simultaneously recorded standard and EASI 12-lead ECGs, using a validated wavelet-based delineator. The agreement between the 2 sets of measurements was quantified both on a lead-by-lead basis

Critical resource levels of pollen for the declining bee Andrena hattorfiana (Hymenoptera, Andrenidae)

The native bee fauna provides an important ecosystem function, but a large proportion of this fauna in Europe is threatened as a result of habitat loss and fragmentation. The solitary bee Andrena hattorfiana is specialised on collecting pollen from the plant-family Dipsacaceae. In northern Europe the major pollen resource is the insect-pollinated herb Knautia arvensis. We quantified the available

Circulatory insulin-like growth factor-I and brain volumes in relation to neurodevelopmental outcome in very preterm infants.

Background:To evaluate the relationships between postnatal change in circulatory insulin-like growth factor I (IGF-I) concentrations, brain volumes, and developmental outcome at 2 years of age in very preterm infants.Methods:IGF-I was measured weekly and nutritional intake was calculated daily from birth until a postmenstrual age (PMA) of 35 weeks. Individual beta coefficients for IGF-I, IGF-I(B)

12-month outcome and predictors of recurrence in psychiatric treatment of depression – a retrospective study.

Many individuals treated for depression suffer relapse or recurrence after treatment. Known risk factors include number of previous depressive episodes and residual symptoms after treatment. Both relapse/recurrence rates and predictors of relapse/recurrence, however, may differ between various settings. To perform a naturalistic evaluation of the sustained effectiveness of treatment for adult clin

Exercise training meta-analysis of trials in patients with chronic heart failure (ExTraMATCH)

Objective To determine the effect of exercise training on survival in patients with heart failure due to left ventricular systolic dysfunction. Design Collaborative meta-analysis. Inclusion criteria Randomised parallel group controlled trials of exercise training, for at least eight weeks with individual patient data on survival for at least three months. Studies reviewed Nine datasets, totalling

Autism and auditory brain stem responses

Objective: To study a controversy that has been discussed for more than two decades: whether or not children with autism have abnormalities affecting the cochlear nerve or the auditory pathway in the brain stem and, if so, to describe these abnormalities. Design: A group of 153 children and adolescents with autistic disorder were included in an investigation of auditory brain stem responses (ABR).

Autologous and allogeneic stem cell transplantation in adult ALL: the Swedish Adult ALL Group experience

Adult patients with acute lymphoblastic leukaemia ( ALL) have been treated according to national protocols in Sweden since 1986. Stem cell transplantation (SCT) has been recommended in first remission for patients with risk factors for relapse, and for standard risk patients only after relapse. In this retrospective study, the results of autologous and allogeneic SCT in these populations were eval