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Computer simulation can provide valuable insight into the forces driving biomolecular liquid-liquid phase separation. However, the simulated systems have a limited size, which makes it important to minimize and control finite-size effects. Here, using a phenomenological free-energy ansatz, we investigate how the single-phase densities observed in a canonical system under coexistence conditions dep
Depression is a common, recurrent disorder. There is a need for readily available treatments with few negative side effects, that demands little resources and that are effective both in the short- and long term. Our aim was to investigate the long-term effectiveness of two different interventions; physical exercise and internet-based cognitive behavioural therapy (internet-CBT), compared to usual
AIM: We aimed to study the importance of erbB2 status in early stage postmenopausal breast cancer for patients who participated in a trial of five vs. two years of adjuvant tamoxifen.PATIENTS AND METHODS: We analysed the erbB2 status of the tumours from 577 patients participating in the trial, either by a DNA amplification assay (n = 181) or by measurement of the protein level with flow cytometry
BackgroundRight ventricular (RV) function is a major determinant of outcome in patients with pulmonary hypertension. Cardiac magnetic resonance (CMR) is gold standard to assess RV ejection fraction (RVEFCMR), however this is a crude measure. New CMR measures of RV function beyond RVEFCMR have emerged, such as RV lateral atrio-ventricular plane displacement (AVPDlat), maximum emptying velocity (S’C
Mate choice in plants is poorly understood, in particular its indirect genetic benefits, but also the direct benefits of avoiding harmful matings. In the herb Collinsia heterophylla, delayed stigma receptivity has been suggested to enhance pollen competition, potentially functioning as a female mate choice trait. Previous studies show that this trait can mitigate the cost of early fertilization ca
New visionary concepts need to be created to enhance the pursuit of sustainable development at a global scale, to respond to policies and international multilateral agreements in line with political commitments already made (like the Millennium Development Goals) and innovative approaches are called for to ensure the coherence of integrated policy-making at EU level.
The upcycling trend has received renewed attention in the past few years due to growing concerns for the environment related to increased resource consumption and waste volumes. Indeed, cities across the world are supporting resource upcycling initiatives by establishing do-it-yourself (DIY) repair cafes and makerspaces as a means to transform societies towards sustainable develop-ment. However, t
The depletion of disruptive variation caused by purifying natural selection (constraint) has been widely used to investigate protein-coding genes underlying human disorders 1–4, but attempts to assess constraint for non-protein-coding regions have proved more difficult. Here we aggregate, process and release a dataset of 76,156 human genomes from the Genome Aggregation Database (gnomAD)—the larges
Decreasing floral resources as a result of habitat loss is one of the key factors in the decline of pollinating insects worldwide. Understanding which plants pollinators use is vital to inform the provision of appropriate floral resources to help prevent pollinator loss. Using a globally important pollinator, the honeybee, we show how changes in agricultural intensification, crop use and the sprea
Measurements of fetal aortic blood flow velocity and fetal growth were performed in 178 pregnancies. In 87 cases, the estimated fetal weight was > 2 SD below the gestational age-related mean of the population. Three fetuses died in utero. In 148 children (84%) an assessment of overall intellectual ability was performed at 6.5 years of age. Verbal and global IQ was lower in the group with an abnorm
Measurements of fetal aortic blood flow velocity and fetal growth were performed in 178 pregnancies. In 87 cases, the estimated fetal weight was > or = 2 SD below the gestational age-related mean of the population. Three fetuses died in utero. In 149 children (85%), a neurological examination was performed at 7 years of age with special emphasis on minor neurological dysfunction. The frequency of
Grass (Poaceae) pollen is the most important outdoor aeroallergen,1 exacerbating a range of respiratory conditions, including allergic asthma and rhinitis ("hay fever").2-5 Understanding the relationships between respiratory diseases and airborne grass pollen with a view to improving forecasting has broad public health and socioeconomic relevance. It is estimated that there are over 400 million pe
Allergic rhinitis is an inflammation in the nose caused by overreaction of the immune system to allergens in the air. Managing allergic rhinitis symptoms is challenging and requires timely intervention. The following are major questions often posed by those with allergic rhinitis: How should I prepare for the forthcoming season? How will the season's severity develop over the years? No country yet
Gränser mellan vegetationszoner fascinerar genom att på ett tydligt sätt påminna oss om sambanden som finns mellan det som lever och dess miljö. En av de mest påtagliga gränserna är den alpina trädgränsen, där fjällbjörkskogen gradvis övergår till kalfjäll. Den karga miljön som utgör kalfjället är starkt kopplat med temperatur och klimatförändringens ökade temperatur har medfört förändringar i träAerial photo interpretation shows a recent densification of trees has been occurring between 1960 and 2009 in the mountain birch (Betula pubescens ssp. czerepanovii) forest of the treeline ecotone in northern Swedish mountains. The correlation between treeline position and annual temperature is commonly accepted and advancing treelines are considered to be a useful indicator for monitoring climate
Climate change and disasters pose a serious risk to sustainable development. In the South local coping strategies are an important element of adaptation to climate and disaster risk. Such strategies have arisen because of the limited assistance provided by urban actors and associated social security and governance systems. In contrast, in the North local coping strategies are comparatively poorly
The development of integrated pest management is hampered by lack of information on how insect pest abundances relate to yield losses, and how pests are affected by control measures. In this study, we develop integrated pest management tactics for Apion spp. weevils (Coleoptera: Brentidae) in seed production of red clover, Trifolium pratense L. We tested a method to forecast pest damage, quantifie
The world supply and turnover of copper was modelled using simple empirical estimates and a COPPER systems dynamics model developed for this study. The model combines mining, trade markets, price mechanisms, population dynamics, use in society and waste as well as recycling, into a whole world system. The degree of sustainability and resource time horizon was estimated using four different methods
Populärvetenskaplig sammanfattning: Småvatten är en svacka eller hålighet som är vattenfylld året om. Dessa småvatten fyller många viktiga funktioner i naturen. De fungerar som utjämnare av flödesvariationer, uppehållsplats och födoplats för många djur och växter och som rena estetiska inslag i naturen, och inte minst som reningsplatser för oönskade näringsämnen så som kväve. Dessa småvatten har iWetlands play an important role in the ecosystem. They reduce the impact of flow flux in the drainage area, acts as upholder of biodiversity, as an esthetic and recreational component in the landscape and they have the ability to reduce nutrients such as nitrogen, and help preventing eutrophication in costal areas. The number of wetlands in Scania have, due to the intensified agriculture been redu
