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The objective of the present study was to develop an experimental model suitable for studying the effects of a nonhemorrhagic soft tissue trauma on plasma volume (PV) and microvascular permeability. Anesthetized Sprague-Dawley rats were exposed to a sham procedure or a laparotomy followed by a standardized trauma to the abdominal rectus muscle. We evaluated the effects of trauma on transcapillary
The classical system for presentation of the 12-lead electrocardiogram (ECG) reflects the electrical activity of the heart as viewed in the transverse plane by 6 leads with a single anatomically ordered sequence, V1-V6; but in the frontal plane by 6 leads with dual sequences, I, II, and III, and aVR, aVL, and aVF. However, there is also a single anatomically ordered sequence of leads, called the C
A methodology for evaluation of natural draft cooling tower (CT) performance and its application is presented. The study establishes the connection between CT performance and power output. It can estimate a change in a CT’s efficiency as well as an increase in power output as a function of cooling water temperature and load to the plant. The methodology consists of three subparts, i.e. Cooling Tow
Robot-assisted surgery is a promising technical innovation. Given the similarities between laparoscopic and robot-assisted surgery it is unlikely that randomized controlled trials would be conducted to disclose any differences between these two technical instruments. Thus, skepticism remains due to lack of any definitive conclusions in the literature.
III-V-based nanowires usually exhibit random mixtures of wurtzite (WZ) and zinc blende (ZB) crystal structure, and pure crystal phase wires represent the exception rather than the rule. In this work, the effective group V hydride flow was the only growth parameter which was changed during MOVPE growth to promote transitions from WZ to ZB and from ZB to WZ. Our technique works in the same way for a
Aim: To describe the use of mobility devices among people ageing with spinal cord injury (SCI), with a specific focus on use of powered mobility devices (PMD) and housing accessibility. Method: Data on the use of walking aids (cane, crutch/es or rollator), manual wheelchair and powered wheelchair/scooter were utilized. To describe functional limitations, environmental barriers and the magnitude of
Dementia is the most common cause of functional decline among elderly people and is associated with high costs of national healthcare in European countries. With increasing functional and cognitive decline, it is likely that many people suffering from dementia will receive institutional care in their lifetime. To delay entry to institutional care, many European countries invest in home and communi
To evaluate the progression of carotid intima-media thickness (IMT) in the common carotid artery (CCA) and the bifurcation over a mean follow-up of 16 years in relation to cardiovascular risk factors.
Perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) blood levels are commonly used as biomarkers of human environmental exposure to these compounds. Many biomonitoring studies indicate 100% detection for PFOS and PFOA thus justifying a concern of possible risk for the most exposed individuals. This study addresses the predictive value of hazard quotients (HQs) calculated on the basi
Single cell transcriptomics identifies stem cell-derived graft composition in a model of Parkinson’s disease ARTICLE Single cell transcriptomics identifies stem cell-derived graft composition in a model of Parkinson’s disease Katarína Tiklová1,2,6, Sara Nolbrant 3,6, Alessandro Fiorenzano3,6, Åsa K. Björklund 4, Yogita Sharma3, Andreas Heuer 3, Linda Gillberg1,2, Deirdre B. Hoban3, Tiago Cardoso
https://www.regenerative-neurobiology.lu.se/sites/regenerative-neurobiology.lu.se/files/publication_in_nature_com.pdf - 2026-07-25
Popular Abstract in Swedish Kroppens immunförsvar brukar delas in i det medfödda och det adaptiva immunförsvaret. Det medfödda immunförsvaret reagerar snabbt på yttre hot såsom bakterier. Olika sorters vita blodkroppar är väldigt viktiga för detta snabba svar på infektion och i min avhandling har jag koncentrerat mig på en av dessa; neutrofilen. Neutrofilen är den vita blodkropp som först koNeutrophil elastase (NE) has important roles in innate immunity, killing pathogens and controlling the immune response; but how NE is targeted to developing granules is not understood. Therefore, the aim of this thesis was to investigate the sorting of NE. Transfection experiments in a leukemic cell line, which were confirmed in normal hematopoietic cells, showed that a population of proNE was ta
Prostacyclin is the major arachidonic acid metabolite of the vascular endothelium and is produced mainly via the cyclooxygenase-2 pathway. By acting on the prostacyclin (IP) receptor on platelets and vascular smooth muscle cells, prostacyclin exerts vasodilatory and antiaggregative/antiadhesive effects. Previous studies have shown that prostacyclin production increases after brain trauma, but the
Background. In SBRT of lung tumours no established relationship between dose-volume parameters and the incidence of lung toxicity is found. The aim of this study is to compare the LQ model and the universal survival curve (USC) to calculate biologically equivalent doses in SBRT to see if this will improve knowledge on this relationship. Material and methods. Toxicity data on radiation pneumonitis
The concept, design and prototype developments for the Lund-York-Cologne CAlorimeter (LYCCA) is presented. LYCCA is a modular device for the NUclear STructure, Astrophysics and Reactions (NUSTAR) science pillar of the Facility for Antiproton and Ion Research (FAIR) at Darmstadt, Germany. LYCCA is designed to discriminate heavy ions produced in nuclear reactions induced by relativistic radioactive
The discipline of epidemiology, which holds major influence on public health policy as well as on clinical medical practice, has in recent decades to a large extent been concerned with the identification of factors and markers of risk for disease. Much health information and intervention is thus informed by a wealth of studies on a variety of risk factors, of which the individual is encouraged to
This study analyses the performance of the satellite derived Plant Phenology Index (PPI) against the Normalized Difference Vegetation Index (NDVI) for estimating start of season (SOS) and end of season (EOS) of vegetation growth in part of the Balkan Peninsula, Southeastern Europe (2000 – 2016). Results revealed that PPI and NDVI differ considerably; SOS and EOS may diverge by more than one month
In modern history, Sweden has experienced two major financial crises: the early 1990s and the global financial crisis in 2008. During the last decades, there has been an increased global focus on regulating and supervising banks, where Basel III is the leading framework. Today, one of the most debated issues within the global economy is Covid-19. It is uncertain how the pandemic will affect countr
Purpose: In 2019 Varian EthosTM linear accelerator (Varian Medical Systems, CA, USA) with integrated artificial intelligence (AI) was installed at Herlev Hospital, Copenhagen, Denmark, enabling online adaptive radiotherapy (oART) e.g for bladder cancer patients with a large margin reduction. The AI utilizes so called influencers for initial delineation of the targets and organs at risks (OAR) usin
Old age is something that affects everyone, sooner or later and in different ways. The question on how to take care of older persons and support them when getting older might be more relevant now than ever, as the population over 60 years old is expected to grow with 40 percent in the coming 10 years. In an older human being, every age is preserved. In an 80-year-old mind there might live a little
