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Background— The inverse relationship between pulmonary function and incidence of cardiovascular disease remains largely unexplained. This prospective study explored the hypothesis of a relationship with inflammation-sensitive plasma proteins. Methods and Results— Forced vital capacity (FVC) and plasma levels of fibrinogen, {alpha} 1-antitrypsin, haptoglobin, ceruloplasmin, and orosomucoid were de
I-131 radionuclide therapy studies have not shown a strong relationship between tumor absorbed dose and response, possibly due to inaccuracies in activity quantification and dose estimation. The goal of this work was to establish the accuracy of I-131 activity quantification and absorbed dose estimation when patient-specific, 3-dimensional (3D) methods are used for SPECT reconstruction and for abs
Objective Obstructive sleep apnoea (OSA) confers a risk of hypertension and cardiovascular complications. Both the renin-angiotensin-aldosterone system and OSA are important determinants of blood pressure, but it is not fully known how they interact. The aim of this study was to explore the interaction between the angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism and O
The paper explores parental perception of social dangers in the urban environment as a constraint for children to walk and cycle. Group discussions with 37 Swedish and 35 English parents of 7 to 12 year old children revealed that social dangers related to strangers, criminality and drugs concerned parents in both countries. These concerns also influenced travel mode choices for their children’s jo
Measurements of the stopping forces for C-14, N-14 and O-16 ions in Ge and Au, for N-14 and F-19 ions in Ag, as well as for F-19 ions in Au have been made, respectively. A novel technique, reported recently, using PIN diodes coated directly with the stopping medium in a polka dot pattern was used. This provided a set of precise, self-consistent measurements on the same stopping medium. Results sho
A multicenter, open-label, randomized efficacy and safety study was performed with combined human chorionic gonadotropin (hCG) and recombinant follicle-stimulating hormone (recFSH) (Puregon(R)) treatment to induce spermatogenesis in hypogonadotropic hypogonadal male patients. Patients were pretreated for 16 weeks with hCG to normalize testosterone levels. A total of 30 of 49 (61%) subjects had nor
Planar gamma-scintigraphy is often used to quantify pulmonary deposition patterns from aerosol inhalers. The results are quite different from those obtained using 3-dimensional PET and SPECT. The purpose of this study was to characterize the effects of scatter and tissue attenuation on the distribution of radiolabeled aerosol as measured by planar scintigraphy using Monte Carlo simulations. This s
Background: There are at least three broad conceptual models for the impact of the social environment on adult disease: the critical period, social mobility, and cumulative life course models. Several studies have shown an association between each of these models and mortality. However, few studies have investigated the importance of the different models within the same setting and none has been p
Return sludge from two Swedish and two Danish wastewater treatment plants were hydrolysed in laboratory reactors. Treatment plants with/without pre-sedimentation and with/without nitrification were represented. Soluble organic matter was produced from all types of sludge, but the yield was to a large extent dependent on what type of sludge was hydrolysed. Activated sludge from wastewater treatment
Aims To examine the prognostic importance of weight-change in patients with coronary artery disease (CAD), especially following acute myocardial infarction (AMI). Methods and results In 4360 AMI patients (OPTIMAAL trial) without baseline oedema, we assessed 3-month weight-change, baseline body mass index (BMI), demographics, patient history, medication, physical examination, and biochemical analys
Urbanization and Density in Zanzibar - Recommendations for Sustainable Urban Development from Swahili houses to low-rise multi-storey houses. The rapid urbanization process in Africa is a major challenge for politicians, urban planners and society in general. The archipelago of Zanzibar in Tanzania is in the middle of this process. Traditionally, low and middle income families live in Swahili hous
In 2012, the Greater Mekong Sub-region (GMS), an initiative launched by the Asian Development Bank (ADB) to promote regional integration and development between six mainland Southeast Asian countries, will reach its twentieth anniversary. Throughout the past twenty years, the GMS has been considered as highly successful, in comparison with other regional initiatives, in improving connectivity, com
Power grids worldwide are expanding not only driven by ambitious clean energy, but also because of the rising need for reliable energy. Key components of these power grids are transformers. Transformers are traditionally filled with mineral oil, to serve as a coolant and dielectric insulator. Now globally a rising trend is observed towards the adoption of less flammable, biodegradable transformer
Popular Science Summary Konsten att kunna ta bort ett syre Alla celler har DNA, som måste repareras och kopieras för att livet ska fortgå. För att kunna göra detta måste det finnas byggstenar. En av alla processer som ser till att alla delar finns i rätt mängd innefattar bara ett protein. Ett protein som får instruktioner från många håll för att gå igenom en komplicerad process som tillverkar dessThe protein ribonucleotide reductase catalyses the de novo synthesis of deoxyribonucleotides (dNTPs) from ribonucleotides (NTPs), using radical chemistry. It is under strict allosteric regulation, partly from the dNTPs it synthesises that regulate what substrate should be synthesised, but also from dATP/ATP, which regulates overall activity. It is a protein that is found in almost every living org
Traditional, pre-industrial farming was adapted to the natural environment-topography, geology, hydrology, climate, and biota. Traditional land use systems are still to be traced in Scandinavia as an "infield/outland landscape", and in Japan as a "Satoyama landscape." There are obvious similarities and differences in land use-the main difference being that pasturing of cattle and sheep has been le
Context: The dipeptidyl peptidase-4 inhibitor, vildagliptin, inhibits glucagon secretion at hyperglycemia but appears to enhance glucagon counterregulation during hypoglycemia in type 2 diabetes.Objective:The objective of the investigation was to study whether vildagliptin also improves α-cell function in type 1 diabetes (T1D). Patients and Methods: The study was a single-center, double-blind, ra
