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In the present study, neuronal and Schwann cell marker proteins were used to biochemically characterize the spatiotemporal progress of degeneration/regeneration in the silicone chamber model for nerve regeneration. Rat sciatic nerves were transected and the proximal and distal stumps were inserted into a bridging silicone chamber with a 10-mm interstump gap. Using dot immunobinding assays, S-100 p
We study the class of state-space models and perform maximum likelihood estimation for the model parameters. We consider a stochastic approximation expectation–maximization (SAEM) algorithm to maximize the likelihood function with the novelty of using approximate Bayesian computation (ABC) within SAEM. The task is to provide each iteration of SAEM with a filtered state of the system, and this is a
In this study, steady-state laminar natural convection of Cu and TiO2 nanofluids inside different enclosures is numerically investigated. Natural convection is concerned due to a temperature difference between the hot and cold surfaces. The Boussinesq approximation is used to form the governing equations and the commercial software package ANSYS Fluent version 14.0 is used to numerically solve the
Technetium is a synthetic element with no stable isotopes, produced as waste in nuclear power plants and in cyclotrons used for nuclear medicine. The element has high mobility, in the form of TcO4 −; its determination is therefore important for environmental protection. Technetium is found in low concentrations and therefore common methods for its analysis include long treatments in several steps
This study aims to assess the potential of trees for integration in urban development by evaluating the damage caused by trees in relation to various tree characteristics. Tree damage to permeable pavement systems and other urban structures such as impermeable pavements, kerbs, roads, retaining walls, footpaths, walls and buildings were assessed to identify the most suitable trees for the urban en
This article explores push-pull dynamics in television drama production and reception. Push-pull dynamics are understood as complicated power relations in the transactions between television industries and audiences. The research is underpinned by qualitative data, drawing on more than 170 participants in interviews, focus groups, and participant observations, with producers and audiences from Nor
In a recent issue of Nature, Falkner et al. (2016) use chronic two-photon imaging, virus-based transsynaptic tracing, and dynamic calcium indicators to elegantly demonstrate extensive in vivo functional maturation and target-specific functional integration of transplanted embryonic mouse cortical progenitors into adult lesioned visual cortical circuits.
Glutathione (GSH) reduction of the anticancer-active platinum(IV) compounds trans-[PtCl4(NH3)(thiazole)] (1), trans-[PtCl4(cha)(NH3)] (2), cis-[PtCl4(cha)(NH3)] (3) (cha=cyclohexylamine), and cis-[PtCl4(NH3)2] (4) has been investigated at 25 °C in a 1.0 M aqueous medium at pH 2.0–5.0 (1) and 4.5–6.8 (2–4) using stopped-flow spectrophotometry. The redox reactions follow the second-order rate law d[
Large volumes of data from satellite sensors with high time-resolution exist today, e.g. Advanced Very High Resolution Radiometer (AVHRR) and Moderate Resolution Imaging Spectroradiometer (MODIS), calling for efficient data processing methods. TIMESAT is a free software package for processing satellite time-series data in order to investigate problems related to global change and monitoring of veg
We study the problem of decomposing a measured signal as a sum of decaying exponentials. There is a direct connection to sums of these types and positive semi-definite (PSD) Hankel matrices, where the rank of these matrices equals the number of exponentials. We propose to solve the identification problem by forming an optimization problem with a misfit function combined with a rank penalty functio
Background: Indications for negative-pressure wound therapy (NPWT) in vascular surgical patients are expanding. The aim of this review was to outline the evidence for NPWT on open and closed wounds. Methods: A PubMed, EMBASE and Cochrane Library search from 2007 to June 2016 was performed combining the medical subject headings terms 'wound infection', 'abdominal aortic aneurysm (AAA)', 'fasciotomy
The use of cross-flow ultrafiltration for the recovery of coating material from aqueous streams started about 30 years ago with electro-deposition paint in the automotive industry. This early success can be related to both environmental and economical advantages of using ultrafiltration. Ultrafiltration recovers and concentrates electro-deposition paint on the retentate side and produces purified
We consider a fifth-order Kadomtsev–Petviashvili equation which arises as a two-dimensional model in the classical water-wave problem. This equation possesses a family of generalized line solitary waves which decay exponentially to periodic waves at infinity. We prove that these solitary waves are transversely spectrally unstable and that this instability is induced by the transverse instability o
Four methods for deriving partial atomic charges from the quantum chemical electrostatic potential (CHELP, CHELPG, Merz-Kollman, and RESP) have been compared and critically evaluated. It is shown the charges strongly depend on how and where the potential points are selected. Two alternative methods are suggested to avoid the arbitrariness in the point-selection schemes and van der Waals exclusion
Despite the performance gains of heat exchangers by thermal-hydraulic optimization, many design approaches suffer from a long process of trial-and-error, limited practical problem formulation and poor robustness. This paper addresses those challenges and develops an optimization framework for designing multi-stream compact heat exchangers. The optimization framework consists of a multi-stream matc
