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Aims and objectives. The aim of the study was to investigate the quality of life and related factors among older people who are in pain and in need of help to manage daily living. Background. To intervene against the low quality of life in nursing care knowledge about factors affecting it is needed and this is especially important for vulnerable people such as those who suffer from pain and who a
The topic of this thesis is estimation of nonlinear dynamical systems, focusing on the use of methods such as particle filtering and smoothing. There are three areas of contributions: software implementation, applications of nonlinear estimation and some theoretical extensions to existing algorithms. The common theme for all the work presented is the pyParticleEst software framework, which has b
Collagen induced arthritis (CIA) is the most studied animal model for rheumatoid arthritis and is associated with the MHC class II molecule A(q). T-cell recognition of a peptide from type II collagen, C11256-270, bound to A(q) is a requirement for development of CIA. Lysine 264 is the major T-cell recognition site of C11256-270 and CIA is in particular associated with recognition of lysine 264 aft
Huntington's disease (HD) is a neurodegenerative disorder caused by an unstable CAG repeat. For patients at risk, participating in predictive testing and learning of having CAG expansion, a major unanswered question shifts from "Will I get HD?" to "When will it manifest?" Using the largest cohort of HD patients analyzed to date (2913 individuals from 40 centers worldwide), we developed a parametri
This report presents and comments on the Swedish part of a survey made in autumn 2007 to obtain expert opinions on industrial relations in the EU25 and G7 countries in the year 2025. The survey was carried out by the European Foundation for the Improvement of Living and Working Conditions (Eurofound). One of the basic questions was about how the process of globalisation will influence future indus
As a complementary product to the Tetra Brik Aseptic packaging system, Tetra Pak is about to introduce a new, value added, aseptic packaging system called SCAP. The SCAP packages consists of a lower part made of carton and an upper part made of plastic, similar to a PET-bottle, resulting in a bottle shaped package. The purpose of this thesis is to design a logistical- and material-handling system
The ATLAS luminosity monitor, LUCID (LUminosity Cherenkov Integrating Detector), had to be upgraded for the second run of the LHC accelerator that started in spring 2015. The increased energy of the proton beams and the higher luminosity required a redesign of LUCID to cope with the more demanding conditions. The novelty of the LUCID-2 detector is that it uses the thin quartz windows of photomulti
Chronic liver disease (CLD) is frequently seen in the hemophilia population. The ADVANCE Working Group conducted a cross-sectional study in which people with hemophilia (PWH) aged ≥40 years were included. This study aimed to assess the associations between CLD and its risk factors using data from the H3 study, and to suggest implications for optimal care.Data from 13 European countries were collec
In this two part paper a theory is presented in which several control problems can be solved. The theory is applicable to a general class of linear multivariable systems where the measured output does not have to be equal to the controlled output or the state. The system may be affected by nonmeasurable disturbances. Only controllers which stabilize the system and have proper transfer functions ar
The study of general linear multivariable systems, with possibly different controlled and measured outputs, is continued in this part of the paper. The structure matrices, defined in Part I, are used to solve the feedback realization problem. Feedback realizable transfer functions are then used to solve problems of "regulator type." It is shown that the solutions to problems like disturbance deeou
The healthcare systems of today are facing large challenges, with increasing amounts of patients and overworked hospital staff. Prostate cancer and Alzheimer’s disease are two of the most prevalent diseases, with incidence numbers expected to rise over the coming decade. Medical imaging plays a central role in current diagnostic procedures for these diseases, enabling the potential use of machine-
To avoid the scaling of the number of qubits with the size of the basis set, one can divide the molecular space into active and inactive regions, which is also known as complete active space methods. However, selecting the active space alone is not enough to accurately describe quantum mechanical effects such as correlation. This study emphasizes the importance of optimizing the active space orbit
Peritoneal dialysis (PD) uses the peritoneal membrane for dialysis. The peritoneal membrane is a thin layer of tissue that lines the abdomen. The lining is used as a filter to help remove extra fluid and poisonous waste from the blood. Everybody is unique. What is normal for one person’s membrane may be very different from another person’s. The kidney care team wants to provide each person with th
The core cerebrospinal fluid (CSF) Alzheimer's disease (AD) biomarkers amyloid beta (Aβ42 and Aβ40), total tau, and phosphorylated tau, have been extensively clinically validated, with very high diagnostic performance for AD, including the early phases of the disease. However, between-center differences in pre-analytical procedures may contribute to variability in measurements across laboratories.
Rainfall intensity or depth estimates are vital input for hydrologic and hydraulic models used in designing drainage infrastructures. Unfortunately, these estimates are susceptible to different sources of uncertainties including climate change, which could have high implications on the cost and design of hydraulic structures. This study adopts a systematic literature review to ascertain the disreg
Den aisopiska fabeln etablerades som genre i den grekiska antiken och nådde Skandinavien under medeltiden. I svensk kultur upplevde fabeln en storhetstid under den tidigmoderna epoken (1500–1800). Monografin Fabelbruk i svensk tidigmodernitet. En genrehistorisk studie tar ett helhetsgrepp om fabelgenrens historia i Sverige under denna 300-årsperiod. I dialog med ny internationell fabel- och genrefEstablished as a genre in Greek antiquity, the Aesopic fable reached Scandinavia during the Middle Ages. In Sweden, the fable experienced its glory days during the early modern epoch (1500–1800). The monograph Fabelbruk i svensk tidigmodernitet. En genrehistorisk studie [Usage of Fable in Swedish Early Modernity. A Genre History] takes a comprehensive look at the history of fable in Sweden during
