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Reviews and practice guidelines for paediatric obsessive-compulsive disorder (OCD) recommend cognitive-behaviour therapy (CBT) as the psychological treatment of choice, but note that it has not been sufficiently evaluated for children and adolescents and that more randomized controlled trials are needed. The aim of this trial was to evaluate effectiveness and optimal delivery of CBT, emphasizing c

Simulation and computer-aided analysis of complex mechanical systems has become a task of increasing importance in computational mechanics. It requires software tools combining modeling support, efficient generation of the equations of motion as well as modern numerical solution and system analysis techniques.

The research described in this thesis has an interdisciplinary approach dealing with chemical, biological, and technical issues. One objective was to interface miniaturized liquid chromatography (LC) to mass spectrometry, i.e. MALDI-TOF MS and ESI-MS, in an unattended mode for high sensitivity determination of proteins and peptides. The coupling between capillary LC and MALDI was accomplished by e

Vertebrate sex ratios are notorious for their lack of fit to theoretical models, both with respect to the direction and the magnitude of the sex ratio adjustment. The reasons for this are likely to be linked to simpilfying assumptions regarding vertebrate life histories. More specifically, if the sex ratio adjustment itself influences offspring fitness, due to sex-specific interactions among offsp

A radioactive fallout following a nuclear accident can result in contamination of large areas of land. In order to protect human health against ionizing radiation, large-scale decontamination that includes multiple sets of clean-up measures may be necessary. Sweden lacks national experience of this type of large-scale decontamination. There are thus great uncertainties in the effect of such a deco

The European Union (EU) Water Framework Directive is of paramount importance for water management. According to the legal text, coordination with other directives like the Floods Directive is imperative and motivated by potential synergy effects. In this paper, the degree to which such coordination is achieved is evaluated for five Nordic and Baltic countries. The evaluation is based on legal docu

In the coming renewables-based energy transition, global electricity consumption is expected to double by 2050, entailing widespread end-use electrification, with significant impacts on energy efficiency. We develop a long-run, worldwide societal exergy analysis focused on electricity. Our 1900–2017 electricity world database contains the energy carriers used in electricity production, final end-u

Background Colic affects at least 10% of newborns and parents seek help. The aim of this study was to present why infants whose parents sought help for colic, where not included in two colic trials and to describe the use and perceived effect of simethicone and probiotics amongst those infants who were included. Method A quantitative, descriptive sub-study based on unpublished data collected in

In view of global climate change and the increasing energy demand there is a need for renewable energy resources. This thesis discusses an energy-driven biorefinery concept based on the agricultural residues corn stover and wheat straw. The work is divided into two main parts. The first part is concerned with the effects of steam pretreatment and choice of acid catalyst on ethanol and biogas produ

Release of cytotoxic granule proteins from activated eosinophil granules is considered to be a key pathogenic mechanism in eosinophilic diseases. Degenerated eosinophils and extracellular eosinophil granules have been repeatedly depicted. The present overview describes evidence that eosinophil lysis and distribution of free eosinophil granules (as opposed to 'classical degranulation') is an import

The present work reports on the development of a bi-enzyme biosensor using diaphorase from Bacillus stearothermophilus, nicotinamide adenine dinucleotide (NAD(+))- and glutathione (GSH)-dependent formaldehyde dehydrogenase (FDH) from the genetically-engineered methylotrophic yeast Hansenula polymorpha as bio-recognition elements. The sensor architecture comprises a first layer containing diaphoras

Popular Abstract in Swedish Basala ganglierna ligger under hjärnbarken i hjärnan och består av grupper av nervceller som är förbundna med varandra och med hjärnbarken. Till dessa grupper av nervceller hör striatum, globus pallidus, subthalamicus-kärnan och substantia nigra. Patologiska förändringar i olika delar av basala ganglierna orsakar många av de symptom som kännetecknar Huntington's och ParHuntington's disease (HD) is a hereditary neurodegenerative disorder presenting with chorea, dementia and extensive striatal neuronal death. The mechanism through which the widely expressed mutant huntingtin mediates striatal neurotoxicity is unknown. Excitotoxicity, i.e. calcium-dependent cell death induced by activation of NMDA receptors, has been hypothesized to play an important role in HD. Ou

Methods for monitoring seepage and detecting internal erosion are essential for the safety evaluation of embankment dams. Internal erosion is one of the major reasons for embankment dam failures, and there are several tenths of thousands of large embankment dams in the world. Internal erosion is progressing inside the dam, and is sometimes difficult to detect by conventional methods. Therefore, th

Spectrophotometric equilibrium measurements indicate formation of the complexes [Pd(H2O)(3)HSO4](+) and [Pd(H2O)(3)SO4] in the reaction between [Pd(H2O)(4)](2+) and hydrogen sulfate/sulfate in the region: 0.10 less than or equal to [H+] less than or equal to 0.80 M. The stability constants are 0.7 +/- 0.2 and 19 +/- 6 M-1, respectively, at 25 degrees C and 1.00 M ionic strength. The protolysis con

Pile heat exchangers are fast emerging as a potentially viable alternative to the more prevalent borehole heat exchangers for the provision of space heating and cooling. In the last decade or so, the use of geothermal piles has increased sharply in many countries including Belgium, China, Japan, Switzerland, the Netherlands, United Kingdom, and United States, among others. In Sweden, however, inte