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The human diving response - effects of temperature and training

The aim was to elucidate the cardiovascular response associated with breath-hold diving, especially the effects of temperature in its elicitation and the effects of different types of training on the human diving response (DR) and breath-holding time (BHT), and to evaluate the human DR in a mammalian perspective. A model for simulated diving by apnea and facial immersion in cold water was develope

Combining corpus and experimental methods to study dialogic engagement in spoken discourse : an analysis of complement-taking predicates

The main objective of this paper is to challenge the treatment of first-person epistemic and evidential complement-taking predicates (CTPs) in Martin and White’s (2005) APPRAISAL theory, and to offer suggestions for improving the model. Based on the combined results of a corpus-based analysis of CTPs and of a psycholinguistic experiment, we demonstrate that several co-textual and situational facto

Effects of Polylysine and Polyglutamate on Inflammation and the Normal Process of Peritoneal Healing After Surgery

Introduction: Intraperitoneal adhesions are common after abdominal surgery and may lead to serious clinical complications. Previous studies have investigated the possible effects of the polypeptides poly-L-lysine (αPL) and poly-L-glutamate (PG) forming a polymer complex that prohibits local peritoneal adhesions after surgery. The aim of this study was to examine whether the normal process of perit

LPS interactions with immobilized and soluble antimicrobial peptides.

Abstract A promising approach in sepsis therapy is the use of peptides truncated from serum- and membrane-proteins with binding domains for LPS: antimicrobial peptides (AMPs). AMPs can be useful in combination with conventional antibiotics to increase killing and neutralize LPS. Although many AMPs show a high specificity towards bacterial membranes, they can also exhibit toxicity, i.e. non-specifi

Configuration management for distributed development - practice and needs

Configuration management (CM) includes synchronizing and supporting developers in their common development and maintenance of a system. The rapid development of the Internet and time-to-market pressure affects software development. In order to utilize skilled personnel despite geographical location, groups of developers are now working all over the world on the development of common systems, a sit

Non-germ-line encoded residues are critical for effective antibody recognition of a poorly immunogenic neutralization epitope on glycoprotein B of human cytomegalovirus.

The capability of the antibody (Ab) repertoire to mount a response to appropriate epitopes on infectious agents will strongly affect the ability of the immune system to provide protection against disease. Certain epitopes may be poor inducers of immunity but are nevertheless able to promote biologically important protection when recognized by the immune repertoire. We have investigated the recogni

Extreme sequence divergence but conserved ligand-binding specificity in Streptococcus pyogenes M protein.

Many pathogenic microorganisms evade host immunity through extensive sequence variability in a protein region targeted by protective antibodies. In spite of the sequence variability, a variable region commonly retains an important ligand-binding function, reflected in the presence of a highly conserved sequence motif. Here, we analyze the limits of sequence divergence in a ligand-binding region by

Hydrolysis of microcrystalline cellulose by cellobiohydrolase I and endoglucanase II from Trichoderma reesei: Adsorption, sugar production pattern, and synergism of the enzymes

Microcrystalline cellulose (10 g/L Avicel) was hydrolysed by two major cellulases, cellobiohydrolase I (CBH I) and endoglucanase II (EG II), of Trichoderma reesei. Two types of experiments were performed, and in both cases the enzymes were added alone and together, in equimolar mixtures. In time course studies the reaction time was varied between 3 min and 48 h at constant temperature (40degreesC)

Human epidermal energy metabolism is functionally anaerobic

We have reported that epidermal Langerhans cells possess an H+-extruding mechanism signalling their existence in an anaerobic environment. This study highlights the energy metabolism of human epidermis. In their habitual state the keratinocytes contain more lactate than do most other cell types. Their lactate production in vitro is vigorous and independent of oxygen and most of it is released to t

Complete oxidation of CO, ethanol, and ethyl acetate over copper oxide supported on titania and ceria modified titania

Titania and titania modified with 3 and 12 mu mol Ce/m(2) surface area of the titania were prepared and were used as supports for copper oxide. Preparations with 3 and 12 mu mol CuOx/m(2) surface area of the support were tested for the combustion of CO, ethyl acetate, and ethanol. The results show that the Ce-doped titania surface is good as support for CuOx and that the cerium not only enhances t

Self-reported skin complaints: validation of a questionnaire for population surveys

Background Estimation of skin diseases in the community is challenging because we do not easily have access to the nonhealthcare-seeking population. A potential tool is a questionnaire asking for self-reported skin complaints. Such an instrument has not yet been developed. Objectives To validate a simple instrument assessing skin morbidity in the general adult population, to predict clinical skin

Sibling competition affects individual growth strategies in marsh tit, Parus palustris, nestlings.

How do different levels of sibling competition affect nestling growth strategies? We investigated this through the effect of different levels of per capita feeding rate on the average growth rate of nestlings and on individual growth strategies within broods. To manipulate sibling competition, we transferred marsh tit nestlings between nests creating broods with fewer (reduced) or more (enlarged)

Avian pectoral muscle size rapidly tracks body mass changes during flight, fasting and fuelling

We used ultrasonic imaging to monitor short-term changes in the pectoral muscle size of captive red knots Calidris canutus. Pectoral muscle thickness changed rapidly and consistently in parallel with body mass changes caused by flight, fasting and fuelling. Four knots flew repeatedly for 10 h periods in a wind tunnel. Over this period, pectoral muscle thickness decreased in parallel with the decre

A probe for capture and Fe3+-induced conformational change of lactoferrin selected from phage displayed peptide libraries

Linear pentadecamer and cyclic hexamer peptide phage libraries were used to isolate phage clones with binding affinity toward lactoferrins purified from human and bovine milk. Phage clones with high specificity toward lactoferrin were selected with different binding strengths depending on the sequence of the peptide displayed by the phage. Phages coated to a microtiterplate were able to capture la

Electrophysiology of pancreatic beta-cells in intact mouse islets of Langerhans

When exposed to intermediate glucose concentrations (6-16 mol/l), pancreatic beta-cells in intact islets generate bursts of action potentials (superimposed on depolarised plateaux) separated by repolarised electrically silent intervals. First described more than 40 years ago, these oscillations have continued to intrigue beta-cell electrophysiologists. To date, most studies of beta-cell ion channe

Sociology of Law in a Digital Society - A Tweet from Global Bukowina

Is it possible to determine the Facebook Gemeinschaft or the living law of the global file sharing community? What are the social facts of twitter or the intuitive law of Chinese microbloggers? This paper argues that digitization of society, the reliance on digital networks, protocol, algorithms and completely new sets of organisational structures for social communities, have vast implications for

Improving strategies for diagnosing ovarian cancer: a summary of the International Ovarian Tumor Analysis (IOTA) studies

In order to ensure that ovarian cancer patients access appropriate treatment to improve the outcome of this disease, accurate characterization before any surgery on ovarian pathology is essential. The International Ovarian Tumor Analysis (IOTA) collaboration has standardized the approach to the ultrasound description of adnexal pathology. A prospectively collected large database enabled previously

Online sexual behaviours among Swedish youth: associations to background factors, behaviours and abuse

Sexual activity online may result in positive experiences for young people, or lead them to engage in risky behaviours possibly resulting in sexual assault or abuse. The aim of our study was to investigate associations between online sexual behaviours among Swedish youth and background factors as well as aspects of wellbeing. The behaviours investigated were: having sex online with a contact met o

Brottsoffer eller gärningsperson? Kriminalisering av deltagande i kriminella sammanslutningar och betydelsen för unga lagöverträdare i åldern 15–17 år

År 2025 presenterades SOU 2025:2 Några frågor om grundläggande fri- och rättigheter, där en kommitté fick i uppdrag att bland annat utreda om ökade möjligheter bör införas för att begränsa föreningsfriheten i förhållande till kriminella sammanslutningar. Kommittén drog slutsatsen att sådana möjligheter bör införas, och några månader senare presenterades kommittédirektiv 2025:28 Kriminalisering av In 2025, the government presented the report SOU 2025:2, Some Issues Concerning Fundamental Rights and Freedoms, which tasked a committee with, among other matters, examining whether the freedom of association should be restricted in relation to criminal organizations. The committee concluded that such measures should be introduced and a few months later Directive 2025:28, Criminalization of Parti

Att sammanjämka rättigheter - En studie av utrymmet för lagstiftaren respektive rättstillämparen att göra avvägningar mellan skyddet av personuppgifter och tryck- och yttrandefriheten enligt dataskyddsförordningen

I Sverige har alla rätt till skydd av personuppgifter, rätt att ta del av allmänna handlingar och yttrandefrihet. Rättigheterna skyddas av såväl våra nationella grundlagar som av EU:s primärrätt och EKMR. Det är dock inte ovanligt att det uppstår situationer där dessa rättigheter ställs emot varandra. Exempel på sådana situationer är när en enskild begär att dennes personuppgifter tas bort från enEveryone in Sweden has the right to protection of personal data, the right to access public documents, and freedom of expression. These rights are protected by our national constitution, EU primary law, and the European Convention on Human Rights. However, it is not uncommon for situations to arise where these rights conflict each other. Such an example is when an individual requests that their pe