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Identification and Functional Characterization of G6PC2 Coding Variants Influencing Glycemic Traits Define an Effector Transcript at the G6PC2-ABCB11 Locus.

Genome wide association studies (GWAS) for fasting glucose (FG) and insulin (FI) have identified common variant signals which explain 4.8% and 1.2% of trait variance, respectively. It is hypothesized that low-frequency and rare variants could contribute substantially to unexplained genetic variance. To test this, we analyzed exome-array data from up to 33,231 non-diabetic individuals of European a

Formation of amylose-lipid complexes and effects of temperature treatment. Part 2. Fatty acids.

This article is the second part of research on amylose-lipid complexes, where the first article dealt with monoglycerides. Here, a variety of fatty acids with chain lengths between 3 and 22 carbons and with varying degree of unsaturation were studied regarding their ability to form amylose-lipid complexes. In the present paper it is intended to investigate the formation of different fatty acid- am

Open access and closed discourses: Constructing open access as a development issue.

This thesis investigates the connection between open access – the free online availability and distribution of scientific and scholarly publications – and the ‘developing world’ from a post- development perspective. It takes a discourse analytical approach, drawing predominantly on Michel Foucault’s understanding of discourse. It aims to answer the following questions: - Which notions of science,

Short-Pulse Laser Spectroscopy for Combustion Diagnostics - Laser-Induced Fluorescence of Polyatomic Molecules and Developments in Measurement and Evaluation

Popular Abstract in Swedish Förbränning är den viktigaste energikällan på jorden och en ökad förståelse av förbränningsprocesser är väsentlig för att minska miljöfarliga utsläpp och för att öka effektiviteten av förbränningsanläggningar och motorer. För detta ändamål är det viktigt att bestämma bl. a. koncentrationer av ämnen som bildas under förbränningen. Laserbaserade mätmetoder möjliggör berörCombustion is the most important source of energy worldwide. A better understanding of it is essential if pollutant emissions are to be reduced and combustion devices be made more efficient. This requires measurement of physical and chemical combustion parameters. Laser-induced fluorescence (LIF) is widely employed as a laser-diagnostic technique for the detection of combustion species but it suff

Costs of foraging in a dry tropical environment

This study evaluates the costs associated with foraging for birds in a savannah woodland area in central Nigeria. Specifically, it looks at the following questions: 1) how does seasonal variability in food and water availability affect the value of resources to birds in dry environments? 2) Does proximity to water affect foraging decisions? What implication will this have in the management of sava

Att se skogen för alla träd - om konflikten mellan miljö och ägande i svensk rätt

Under senare år har en allt skarpare målkonflikt seglat upp mellan egendomsskyddet och miljöskyddet i svensk rätt. Egendomsskyddet har genom bland annat grundlagsstadgandet i 2 kap 15 § regeringsformen en framskjuten position. Även den svenska miljölagstiftningen, med dess möjligheter till skydd av värdefulla skogsmiljöer, är formellt sett kraftfull i sina styrmedel. Samtidigt tyder mycket på att During the last couple of years, the conflict of aims between statutory protection of property on the one hand, and of the environment on the other, has become more and more tense within Swedish law and public debate. The regulatory protection of property has been strengthened since at least the late 20th century and holds a solid, prominent position in the Swedish constitution. The Swedish envir

Local currencies: a tool for sustainability? : a: transitions perspective on the impacts of local currencies for sustainability : the case of the Bristol Pound

This research investigates the contribution of local currencies to sustainability. I look at a specific local currency scheme (the Bristol Pound, in Bristol, United Kingdom) through a transitions perspective, employing a Transitions Evaluation Framework, Multi-Level and Multi-Phase Perspectives to conduct my analysis. I use a qualitative triangulation approach to collect data, namely semi-structur

Verkligheten i sagoform? : En kvalitativ studie om hur sexuella övergrepp mot barn framställs i barnböcker

Within society, sexual abuse is a subject of taboo and has a number of stigmas attached to it which can make it difficult for children to talk about it let alone make a disclosure as typically can be a relative or someone that the child trusts. The aim of this study was to gain a better understanding of how sexual abuse against children is depicted in children’s literature. Within our study we hav

Byggstandarder & Miljöcertifieringar – En fallstudie på LKF

Problemställning: Hur hållbart bygger LKF? Syfte: Att bidra till framtagandet av en ny, mer hållbar byggstandard. Metod: Litteraturstudie, intervjuer samt jämförelse mellan miljöcertifieringar och LKF:s byggstandard genom ett ”standardprojekt”. Slutsatser: Hållbart byggande har för denna rapport definierats som en balans mellan sociala-, ekonomiska-, ekologiska- och tekniska aspekter kopplat tiProblem: How sustainable does LKF build? Purpose: To contribute to a new construction standard that is more sustainable than the present one. Method: Litterature study, interviews and comparison of environmental assessments and LKF’s construction standard that is represented by a ’standard project’. Conclusions: Sustainable construction has for this report been defined as a balance between soci

Using Geographically Weighted Regression (GWR) to explore spatial variations in the relationship between public transport accessibility and car use : a case study in Lund and Malmö, Sweden

Sedan 1950-talet har antalet bilar per person i Sverige ökat. Med en negativ påverkan på miljön såväl som på människors hälsa, representerar privat ägande av fordon en av de största utmaningarna i transportplanering. Att flytta resenärer från privata fordon till kollektivtrafik har visat sig fördelaktigt beträffande att minska koldioxidutsläppen, dock kräver denna typ av mobilisering politisk styrIn Sweden the number of cars per person has increased since the mid-20th century. With negative impacts on both health and the environment, private ownership of vehicles represents one of the major challenges in urban transport. To move travelers from privately owned vehicles to public transport has shown to be beneficial in reducing carbon emissions. However, in order to create policies that attr

Vem får ansvaret? – En analys av principen om aktieägares frihet från personligt ansvar

Framställningen undersöker två motstående intressen, behovet av välfungerande ansvarsregler för företag och det begränsade ansvaret för aktieägare i aktiebolag. Syftet med framställningen är att framställa principen om aktieägares frihet från personligt ansvar i ett brett perspektiv. Perspektivet breddas genom att undersöka tre begrepp som innebär att moderbolag kan åläggas ansvar för vad som geneThis essay examines two opposing interests: the need of well-functioning rules of liability and the limited liability for shareholders in companies. The purpose of this essay is to portray the principle of shareholders’ limited liability in a broad perspective. The essay widens the scope by examining three concepts that declares that parent companies can be responsible for what is generally the su

Utlämningsförbudet för politiska brott – en anakronism eller viktig beståndsdel i utlämningsrätten?

Utlämningsförbudet för politiska brott har utgjort en del i den svenska utlämningsrätten ända sedan Sveriges första utlämningslag instiftades under tidigt 1900-tal. Några konkreta skäl till varför regeln en gång infördes i svensk rätt angavs aldrig. På ett internationellt plan har däremot tre övergripande skäl kartlagts, vilka ansetts motivera regeln. Skälen utgörs av: (1) att den eftersökte indivThe political offence exception has been a part of the Swedish extradition law since the first extradition law entered into force in the early 20th century. No concrete reasons were given why the rule was once introduced in Swedish law. At the international level, three general reasons have been given to justify the exception: (1) that the requested individual should not be an object for persecuti

Det komplexa bemötandet - röster från en familjerätt i södra Sverige

The aim of this study is to describe and analyze encounters between clients and social workers in a municipality in the southern part of Sweden. Our questions are, what is a social workers opinion of a good encounter; which personal characteristics clients think are most important for social workers in a good encounter; do social workers and clients have a unanimous view of which personal characte

Gemensamt haveri som ansvarsbegränsning

Denna uppsats kommer att behandla den internationella sjörättsprincipen gemensamt haveri samt ställa den mot den svenska lagstiftningen om ansvarsbegränsningar och friskrivningar. Syftet är att kolla på principen ur perspektivet vad den innebär för ansvarsbegränsningar för de inblandade parterna och för att sedan se vad den svenska rätten säger om ansvarsbegränsningar och ställa de två emot varandThis essay will cover the international maritime law principle of general average and put it against the Swedish legislation on limitations of liability and disclaimers. The purpose is to look at the principle from the perspective of what limitations of liability the principle entails for the parties involved and to then look at what Swedish law says about limitations of liability and set the two

Anden, Luther och feminism. En studie i pneumatologi utifrån Svenska kyrkans bekännelse och en feministisk kritik.

This thesis aims to contribute to the theological discussion of how a critical and constructive pneumatology could be seen in the context of the Church of Sweden today. To achieve this purpose, I analyze a Lutheran view of the Holy Spirit in the confession of the Church of Sweden and a feminist criticism. The questions asked are: How does a Lutheran view of the Holy Spirit look according to the co

Automated plane detection and extraction from airborne laser scanning data of dense urban areas

Digital 3D city models are used in many GIS applications, such as urban planning. Manual digitization of 3D buildings is rather tedious, hence automated approaches are much preferred. In this study, a pipeline for automated extraction and estimation of building roof facets from LIDAR data are devised based on available methods and ideas, which is part of the entire frame work of automatic creating

Cognitive Ability and Economic Decision Making - A study comparing cognitive reflection and intelligence quotient in decision time in various economic situations

Cognitive ability can be measured with several different instruments. The first thing that springs to mind is probably IQ or knowledge tests, such as the SAT. In 2005, a new test came out on the market, the cognitive reflection test (CRT). This test was constructed differently, namely to capture cognitive reflection, an ability to use system 2 in an effective way. System 2 is a concept from the du

Radioactivity Exploration from the Arctic to the Antarctic. Part 2. Ymer-80 Expedition

Abstract Levels of natural radioactivity such as 222Rn (radon) and its long-lived daughters 210Pb and 210Po were measured. The radon gas was trapped on cooled charcoal filters and the long-lived daughter products sampled on fibre filters on a daily basis. In addition, short-lived progenies were followed continuously on the filters in order to achieve a time resolution of about one hour. The ave