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Background: C. pseudotuberculosis is an important animal pathogen that causes substantial economical loss in sheep and goat farming. Zoonotic infections in humans are rare, but when they occur they are often severe and difficult to treat. One of the most studied proteins from this bacterium, the secreted protein CP40 is being developed as a promising vaccine candidate and has been characterized as
Maternally inherited selfish genetic elements are common in animals [1]. Whereas host genetics and ecology are recognized as factors that may limit the incidence of these parasites [2, 3], theory suggests one further factor-interference with other selfish elements-that could affect their prevalence [4, 5]. In this paper, we show that spatial heterogeneity in the occurrence of the male-killing Wolb
Dragon is a word oriented stream cipher submitted to the ECRYPT project, it operates on key sizes of 128 and 256 bits. The original idea of the design is to use a nonlinear feedback shift register (NLFSR) and a linear part (counter), combined by a filter function to generate a new state of the NLFSR and produce the keystream. The internal state of the cipher is 1088 bits, i.e., any kinds of TMD at
To assess whether the water availability measures commonly used in species distribution models might be misleading because they do not account for the hydrological effects of changes in vegetation structure and functioning. Europe. We compared different methods for estimating water availability in species distribution models with the soil water content predicted by a process-based ecosystem model.
Glycosaminoglycans (GAGs) are polysaccharides produced by essentially all mammalian cells. Due to their enormous structural diversity, they are involved in many biological processes both in health and disease, including all stages of tumor progression. GAGs are normally attached to a core protein as a part of a proteoglycan; however, GAG biosynthesis can be induced by compounds composed of a xylos
Objectives Biologic agents have dramatically changed treatment of rheumatoid arthritis (RA). To date only scarce head-To-head data exist especially when the biological therapies are given as monotherapy without concomitant disease modifying drugs (DMARDs). Thus the objective of the current study is to evaluate treatment response of all available biological therapies with special focus on utility (
En majoritet av de nordliga torvmarkerna utvecklades under holocen som ett resultat av en positiv massbalans mellan nettoprimärproduktion och heterotrofa nedbrytningshastigheter. Sedan dess har de lagrat stora mängder kol i terrestra ekosystem. En betydande del av dessa områden sammanfaller också med regioner med underliggande permafrost och uppvisar olika ackumulationsmönster av torv. Således, föThe majority of the northern peatlands developed during the Holocene as a result of a positive mass balance between net primary productivity (NPP) and heterotrophic decomposition rates. Over that time they have sequestered a huge amount of carbon in terrestrial ecosystems. A significant proportion of these areas also coincides with areas underlain with permafrost and shows a diverse range of peat
Context. As observational evidence steadily accumulates, the nature of the Galactic bulge has proven to be rather complex: the structural, kinematic, and chemical analyses often lead to contradictory conclusions. The nature of the metal-rich bulge - and especially of the metal-poor bulge - and their relation with other Galactic components, still need to be firmly defined on the basis of statistica
There is an increasing demand on universities and university colleges to involve student nurses in research and development projects. The aim of this study was to describe different ways of involving students in research and development projects in order to gain empirical material for their own undergraduate projects and to discuss the challenges in involving students in those projects. The study
Introduction It is known that suspended particles are affected by radiation forces when exposed to ultrasound. Suspended particles are gathered in the pressure nodal or pressure anti-nodal planes of an ultrasonic standing wave field depending on the density and compressibility of the particles and the medium. By combining this effect with laminar flow in a silicon micro channel different particle
This paper presents findings on the role of online traveller information services in regional public transport for olderpeople and people with functional limitations. An explanatory mixed methods design was used. A quantitative questionnairestudy of the target group’s need of traveller information and use of online traveller information services provided the basisfor a qualitative focus group stud
På senare år har flera studier visat på att järnhalten ökar i sjöar och vattendrag i norra Europa. Järn spelar en nyckelroll i akvatiska miljöer genom att påverka tillgängligheten av andra näringsämnen i vattnet så som kväve och fosfor, vilket kan reglera tillväxten av växtplankton. Dessutom färgar järn tillsammans med organiskt material vatten brunt. När vattnet blir brunare försämras ljusklimateIron (Fe) concentrations are increasing in freshwaters (lakes and streams) in Sweden, as well as in other regions in northern Europe. Together with increasing concentrations of organic matter, Fe is contributing to the ongoing browning of freshwaters, which may have serious ecological consequences and implications for ecosystem services. The aim of this thesis was to investigated where, to what ex
Renal hyperparathyroidism (rHPT) is a complex and challenging disorder. It develops early in the course of renal failure and is associated with increased risks of fractures, cardiovascular disease and death. It is treated medically, but when medical therapy cannot control the hyperparathyroidism, surgical parathyroidectomy is an option. In this review, we summarize the pathophysiology, diagnosis,
The ice cover presence on the surface of a lake insulates the water body from the atmosphere. This prevents or reduces the influence of processes which depend on the exchange between the atmosphere and the water surface. This implies significant reduction or elimination of some processes taking place at the open water surface; for instance, a substantial reduction in solar energy penetrating to th
Importance: Better understanding is needed of the degree to which individuals tolerate Alzheimer disease (AD)-like pathological tau with respect to brain structure (brain resilience) and cognition (cognitive resilience). Objective: To examine the demographic (age, sex, and educational level), genetic (APOE-ϵ4 status), and neuroimaging (white matter hyperintensities and cortical thickness) factors
Background: A childhood cancer diagnosis and treatment-induced somatic late effects can affect the long-term mental health of survivors. We aimed to explore whether childhood cancer survivors are at higher risk of psychiatric disorders later in life than their siblings and the general population. Methods: In this register-based cohort study (part of the Socioeconomic Consequences in Adult Life aft
This paper attempts to investigate whether there are gender and regional specific differences in risk perception in three municipalities in Sweden. It focuses on differences between gender and region with regard to risk perception, issues of trust and credibility as well as attitudes towards local industry and emergency response behaviour. This study is based on results from a larger study investi
Most off-the-shelf embedded control systems lack proper mechanisms to handle computational overload conditions. Therefore, delays may accumulate and produce overruns, potentially harming the stability and performance of the controlled system. In this paper, we explore a controller implementation in which overrun events are tolerated and tackled with a proper countermeasure, which can be easily plu
The centrality dependence of the charged-particle pseudorapidity density measured with ALICE in Pb-Pb collisions at √sNN=2.76 TeV over a broad pseudorapidity range is presented. This Letter extends the previous results reported by ALICE to more peripheral collisions. No strong change of the overall shape of charged-particle pseudorapidity density distributions with centrality is observed, and when
