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Glioblastoma multiforme is the most common and aggressive malignant brain tumor in humans, and the prognosis is very poor despite conventional therapy. Immunotherapy represents a novel treatment approach, but the effect is often weakened by release of immune-suppressive molecules such as prostaglandins. In the current study, we investigated the effect of immunotherapy with irradiated interferon-γ
Popular Abstract in Swedish Vår kropp är uppbyggd av flera olika typer av stödjevävnader tex ben, brosk, muskler och hud. Den utgör kroppens stomme och bidrar med både stödjande och elastiska funktioner i kroppen. Brosk är en specialiserad form av bindväv som bekläder alla ledytor i kroppen och dess specifika sammansättning förser leden med en i det närmaste friktionslös rörelseförmåga. Broskets The work in this thesis has been focused on chondrocyte integrins and their interaction with the matrix proteins chondroadherin (CHAD) and collagen type II (CII). Affinity purification of CHAD-binding proteins from chondrocyte lysate, followed by immunoprecipitation of EDTA-eluted material identified alpha2beta1 as a CHAD-binding integrin. Interaction between alpha2beta1 and CHAD was found to prev
Popular Abstract in Swedish Vår arvsmassa består av en cirka två meter lång tråd av DNA. Denna långa DNA-tråd är väl hoppackad och alla kärnbärande celler i kroppen har en kopia av den. Tråden kan delas upp i korta segment som utgör våra gener och mellanliggande segment vars uppgift inte är helt klarlagd. Totalt har vi enligt nuvarande beräkningar cirka 30 000 gener. Dessa gener, som innehåller koThe aim the thesis work was to study the human cystatins C, E/M, F, G, H and I both in vivo and in vitro. A mouse devoid of cystatin C was used for the cystatin C studies. The levels of cystatins C, E/M and F were measured in pleural effusion samples of patients with various lung disorders. Cystatin F protein and RNA levels were measured in the human haematopoietic cell line U937 as well as in cel
Popular Abstract in Swedish Dagligen produceras hos en vuxen människa det helt otroliga antalet av 300 miljarder (300.000.000.000) blodkroppar. De flesta är röda blodkroppar som ansvarar för att transportera syre från lungorna till alla celler i kroppen samt koldioxid i andra riktningen. Vidare finns olika sorters vita blodkroppar som skyddar oss från infektioner samt blodplättar (eller trombocyteHematopoietic stem cells (HSCs) are responsible for the daily and life long production of large numbers of mature blood cells through highly regulated self-renewal and multilineage capabilities. Leukemias on the other hand, are characterized by a clonal, dysregulated, lineage skewed proliferation and impaired differentiation as the result of multiple accumulated genetic events. In acute myeloid le
In this paper, multiple-input multiple-output (MIMO) channel measurements in an outdoor micro-cell environment are used to study the effect of base-station (BS) inter-element spacing on multi-user MIMO signal separation. Users with two dual-polarized patch antennas at the mobile station (MS), and four equally-spaced dual-polarized patch antennas at the BS are considered. At the BS, the inter-eleme
Popular Abstract in Swedish Det är en utbredd uppfattning att gränserna mellan högkulturen och masskulturen blivit mindre skarpa i vår postmoderna kultur. Den höga litteraturen lånar friskt former, motiv och grepp från masskulturen – och viceversa. Hur skall man tolka den estetiska trafiken mellan kulturella sfärer – höga respektive låga – som länge ansetts oförenliga? Vad består trafiken av och The Struggle for High and Low Culture. Studies in the Late Twentieth Century Novel’s Relationship to Mass Culture and Modernity. It is a widespread opinion that the boundaries between high culture and mass culture have become less defined in our postmodern culture. How is the aesthetic exchange to be interpreted between cultural spheres – high and low respectively – long considered incompatible?
Scholars of widely diverging persuasions have recognized the implications of the world constellation in which the discourse on foreign intervention with all its manifestations in a civil war has an explanatory value. How-ever, a number of long-standing theoretical, methodological and epistemological challenges still resist clearcut solution. This study analyzes the roles of the great powers and th
The long-range, pheromone-mediated, flight behaviour of male moths under natural and mating disruption conditions was monitored by means of harmonic radar. Individual male turnip moths, Agrotis segetum (Denis & Schiffermüller) (Lepidoptera: Noctuidae), tagged with radar transponders, were released and tracked in plots with or without disruptive doses of sex pheromone. In addition, male attract
Popular Abstract in Swedish SAMMANFATTNING PÅ SVENSKA (Swedish summary) Ultraljud används sedan 1970-talet rutinmässigt under graviditet. Undersökningen görs vanligen vid 17-18 graviditetsveckor och syftet med undersökningen är att datera graviditeten dvs bestämma tiden för beräknad förlossning. Man upptäcker också eventuella tvillingar vid denna undersökning. Redan tidigt visade det sig att visWe studied the prenatal detection rate of various malformations during a study period of 16 years in a population in southern Sweden consisting of 141 240 deliveries. The overall detection rate was 28.4% and the false positive diagnoses were very few. We studied the effect of prenatal diagnosis on the rate of spina bifida in southern Sweden compared with the rest of the country and could show tha
Popular Abstract in Swedish I religionernas värld står inga grupper så nära varandra som judendomen och kristendomen. Inte i något annat fall har det förekommit så mycket okunskap, illvilja och förföljelser. Det är ett ofrånkomligt faktum att Förintelsen ägde rum i den världsdel som mest av alla präglats av den kristna kyrkan. Det är därför en angelägen uppgift att studera den tidigaste kristendomFew passages in the New Testament Gospels can compete with Mk 7:1-23 when it comes to the history of influence in biblical scholarship. Generations of scholars have turned to this pericope in order to find the message of the historical Jesus, the theology of early Christianity or even the essence of Christianity. In this thesis it is argued that the mainstream interpretation of the cardinal saying
Diabetes and obesity have long been known to be related. The recently characterized adipocyte hormone resistin (also called FIZZ3/ADSF) has been implicated as a molecular link between impaired glucose tolerance (IGT) and obesity in mice. A search for sequence variants at the human resistin locus identified nine single-nucleotide polymorphisms (SNPs) but no coding variants. An investigation into th
OBJECTIVE: To examine whether adherence to the modified Mediterranean diet, in which unsaturates were substituted for monounsaturates, is associated with longer life expectancy among elderly Europeans. DESIGN: Multicentre, prospective cohort study. SETTING: Nine European countries (Denmark, France, Germany, Greece, Italy, the Netherlands, Spain, Sweden, United Kingdom). PARTICIPANTS: 74,607 men an
Water extracts of the bark of Uncaria tomentosa, a vine indigenous to South America, has been used for generations as an "immuno modulator". To understand the basis of this immuno modulatory effect we fed mice in their drinking water with C-Med 100, which is a commercially available water extract from Uncaria tomentosa. We found a dose-dependent increase in spleen cell numbers in the supplemented
Twenty years after Vassar College welcomed the first American female undergraduates in 1865, the experiences of women college students began to be fictionalized in so-called college stories. This thesis shows how higher education is presented in the novels, collections of short stories, and serialized stories for female readers published before the United States was involved in the First World Wa
Fibroblasts, being one of the resident and structural cells of the lung, have the capacity to produce inflammatory mediators, cytokines and extracellular matrix (ECM) proteins perpetuating the inflammation in the airways of asthmatics. Airway remodeling is also a prominent feature of asthma that affects the lung function causing a thickening of the airways. An increased ECM production of proteogly
In cases in which experimental data on chemical-specific input parameters are lacking, chemical regulations allow the use of alternatives to testing, such as in silico predictions based on quantitative structureproperty relationships (QSPRs). Such predictions are often given as point estimates; however, little is known about the extent to which uncertainties associated with QSPR predictions contri
Hematopoietic stem cells (HSCs) are maintained in specialized niches in adult bone marrow. However, niche and HSC maintenance mechanism in fetal liver (FL) still remains unclear. Here, we investigated the niche and the molecular mechanism of HSC maintenance in mouse FL using HSCs expressing endothelial protein C receptor (EPCR). The antiapoptotic effect of activated protein C (APC) on EPCR+ HSCs a
The Tibetan Plateau has a significant role with regard to atmospheric circulation and the monsoon in particular. Changes between a closed plant cover and open bare soil are one of the striking effects of land use degradation observed with unsustainable range management or climate change, but experiments investigating changes of surface properties and processes together with atmospheric feedbacks a
Mixtures of two cationic proteins were used to prepare protein-DNA gel particles, employing associative phase separation and interfacial diffusion (Moran et al., 2009a). By mixing the two proteins, we have obtained particles that displayed higher loading efficiency and loading capacity values than those obtained in single-protein systems. However, nothing is known about the adverse effects on haem
Soil disturbance is a common phenomenon in semi-natural sandy grasslands, caused by management practices, livestock trampling and erosion. To better understand ecosystem processes when the surface layers of the soil are disturbed, we investigated the effects of disturbance on different functional microbial groups by the use of signature fatty acid analysis. Four levels of disturbance were investig
