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Single-molecule and single-cell biophysics

To study processes at the level of single molecules and single cells, the tools need to be on the same size scale as the objects under study. We therefore develop micro and nanofluidic devices on scales ranging from tens of nanometers to hundreds of micrometers to manipulate, visualize and sort biomolecules, cells and other bioparticles. Research areas:Single-molecule biosensingNanoconfined molecu

https://www.nano.lu.se/research/life-science-nano/single-molecule-and-single-cell-biophysics - 2026-07-07

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In this thesis recent data on trade between 23 OECD countries and the non-OECD countries, singling out six low or lower middle income countries (Brazil, China, India, Indonesia, Philippines and Thailand), is examined to detect possible technological diffusion which might, according to recent theories on economic growth, lead to an increased growth in the countries in question. Data on total trade

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Popular Abstract in Swedish Bakgrund Hur gatunätet ser ut och planera's i städer påverkar förutom trafikarbetet även hur bilister kör. Körbeteendet i form av körmönster, d.v.'s. hastighet's- och accelerationsprofiler, påverkar i sin tur såväl bränsleförbrukning som avgasemissionsfaktorer. En betydande del av trafiken sker inom tätorter där såväl luftkvalitet som totala utsläpp är av betydelse. ÄvThe planning and design of street networks in cities influence driving behaviour and give rise to variations in driving patterns (i.e., speed and acceleration profiles) that affect exhaust emissions and fuel consumption. The primary objective of this study has been to use real-life driving patterns to investigate how the characteristics of street networks influence fuel consumption and vehicular e

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This thesis concerns the numerical simulations and modelling of the flow structure and scalar transport in stirred reactors. For this Large Eddy Simulations (LES) have been used. The flow situation in a stirred reactor includes several flow phenomena that are not well predicted by "standard" two-equation models, e.g. swirl, stagnation points and anisotropic turbulence. Also, using LES one can obta

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Popular Abstract in Swedish Denna avhandling handlar om hur man kan utläsa klimatiska signaler från klastiska årsvarviga sediment i Ångermanälven i södra Norrland. Avhandlingen bidrar med kunskap till den pågående diskussionen om klimatets- och den hydrologiska cykelns förändringar, framförallt sett ur ett retrospektiv men den behandlar också frågor om framtiden och en eventuellt ökande växthuseffAny future climate variation forced by human activities will be superimposed on the background of natural climate variation. Therefore, before interpreting the present climate and addressing future climate scenarios some knowledge of past climate is necessary. This thesis offers a rare glimpse into a long record of fluvial activity in Central Sweden and illuminates some of the possible forcing age

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Between 1991 and 1994 the number of beds in the surgical clinic at a central hospital in Southern Sweden was cut back by almost 50%. To develop the nursing care and to control the effects of the budgetary cuts, an intervention, including nursing care development, of an organization that would secure continuity in the nurse-patient relationship, individually planned care and quality assurance for a

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Multipotent stem/progenitor cells derived from human first trimester forebrain can be expanded as free-floating aggregates, so called neurospheres. These cells can differentiate into neurons, astrocytes and oligodendrocytes. In vitro differentiation protocols normally yield γ-aminobutyric acid-immunoreactive neurons, whereas only few tyrosine hydroxylase (TH) expressing neurons are found. The pres

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We consider the problem of how to schedule t similar and independent tasks to be performed in a synchronous distributed system of p stations communicating via multiple-access channels. Stations are prone to crashes whose patterns of occurrence are specified by adversarial models. Work, defined as the number of the available processor steps, is the complexity measure. We consider only reliable algo

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The influence of lipid concentration on hydrolysis and biomethanation of a lipid-rich (triolein) model waste was evaluated in batch. The effect of increasing the concentration of lipid from 5% to 47% (w/w), based on chemical oxygen demand (COD), was investigated. The methane recovery observed was above 93% for all tests. An initial lag phase of approximately 6-10 days was observed for all tests. T

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This study describes the evaluation and characterization of a self-nanoemulsifying drug delivery system (SNEDDS) consisting of a nonionic surfactant (Cremophor RH40), a mixture of long chain mono-, di-, and triacylglycerides (Maisine 35-1 and Sesame oil) and ethanol. Compositions containing 10% (w/w) ethanol, 40%-60% (w/w) lipid content, and 30%-50% (w/w) Cremophor RH40 were identified as pharmace

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Orientation experiments were performed with first-year snow buntings (Plectrophenax nivalis) during their autumn migration in a natural near-vertical geomagnetic field approximately 400 km away from the magnetic north pole. Migratory orientation of snow buntings was recorded using two different techniques: orientation cage tests and freeflight release experiments. Experiments were performed under

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This paper proposes a risk assessment model for settling problems of microbiological origin in activated sludge systems (filamentous bulking, foaming and rising sludge). The aim of the model is not to diagnose microbiology-related solids separation problems with absolute certainty but to quantify in dynamic scenarios whether simulated operational procedures and control strategies lead to favourabl

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Cast in-situ concrete is the most frequently used materials technology worldwide within production of structural frames in multi-storey residential buildings. In Sweden, this technology dominates the market but is challenged by other competitive production methods. The criticism concerns issues as for instance short slab spans (limited flexibility for future refurbishment), long production times,

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BackgroundFood habits, nutrient needs and intakes differ between males and females, although few nutritional studies on patients with coeliac disease (CD) have reported results stratified by gender. ObjectivesTo compare energy and nutrient intakes among 13-year olds diagnosed with CD in early childhood with those of a non-coeliac (NC) age- and gender-matched control group, and also with estimated

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Popular Abstract in Swedish De senaste ca trettio åren har man observerat en kraftig ökning av löst organiskt kol i sjöar, vattendrag och kustnära vatten i olika delar av det norra halvklotet, bl.a. i delar av Nordamerika, Storbritannien, Baltikum, centrala Europa och Skandinavien. I Sverige har ökningen främst varit koncentrerad till de södra delarna av landet. Löst organiskt kol i sjöar belägna During the past three decades, increases have been observed in dissolved organic carbon (DOC) concentrations and colour in the surface waters of lakes and rivers in parts of Europe and North America, raising concern about the effects on the quality of aquatic environments with consequences for biodiversity, resource availability and recreational use. Various hypotheses have been put forward to exp

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identity through work gives a necessary context for a meaningful life. Work pace control, autonomy, learning new skills, or participation in company decision making are specific psychological factors included in the job control dimension. On the other hand, high absenteeism and poor health are symptoms used to associate with poor psychosocial working environment. This industry paper presents the e

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Activation of the complement system by tumor cells was long believed to only benefit the host. Overexpression of complement inhibitors by many tumor cell types and results obtained in several experimental animal models were all in agreement with this hypothesis. However, recent reports imply that the situation is more complex than initially believed and that under certain circumstances tumor cells

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Probability distributions of daily maximum and minimum temperatures in a suite of ten RCMs are investigated for (1) biases compared to observations in the present day climate and (2) climate change signals compared to the simulated present day climate. The simulated inter-model differences and climate changes are also compared to the observed natural variability as reflected in some very long inst