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OBJECTIVES: To study long-term patient-relevant outcomes after meniscectomy, a surgical procedure associated with a high risk of knee osteoarthritis (OA). Principal objectives were to compare traumatic with degenerative meniscal tear and partial with subtotal meniscectomy.METHODS: We studied a well-defined cohort of 205 patients who had undergone isolated unilateral meniscectomy between 1983 and 1

Background and aims: To estimate short- and long-term costs of inpatient hospitalization in Sweden for major diabetes mellitus-related events. Materials and methods: Costs were estimated using administrative hospital data from the Swedish National Board of Health and Welfare, which is linked to the Swedish National Diabetes Register. Data were available for 179 749 patients with diabetes in Sweden

Rapid and automatic processing of grammatical complexity is argued to take place during speech comprehension, engaging a left-lateralized fronto-temporal language network. Here we address how neural activity in these regions is modulated by the grammatical properties of spoken words. We used combined magneto- and electroencephalography to delineate the spatiotemporal patterns of activity that supp

Purpose: The purpose of this work was to evaluate the visibility of simulated lesions in 2D digital mammography (DM) and breast tomosynthesis (BT) images of patients. Methods: Images of the same women were acquired on both a DM system (Mammomat Novation, Siemens Healthcare, Erlangen, Germany) and a BT prototype system adapted from the same type of DM system. Using the geometrical properties of the

Abstract: Purpose – While the importance of measuring customer satisfaction levels is well established, less research exists on how organizations operationalize such knowledge. The purpose of this paper is to describe an action research (AR) case study resulting in a workshop model to operationalize the concept of value. The model facilitates organizational learning and mindset changes in order to

Popular Abstract in Swedish Variabilitet i ett läkemedels farmakokinetiska (hur ett läkemedel omsätts i kroppen) och farmakodynamiska (vilken effekt ett läkemedel har) egenskaper kan resultera i att olika individer som erhållit samma dos av ett läkemedel får olika effekter av läkemedel. Biverkningar eller utebliven effekt kan innebära allvarliga konsekvenser för den enskilda individen. VariabiliteVariability in pharmacokinetic and pharmacodynamic parameters between individuals can be due to intrinsic and extrinsic factors. In this thesis three different areas regarding sources of variability have been investigated. 1. Formulation properties as an extrinsic source of variability. Lipophilic substances often have poor oral bioavailability and high inter- and intraindividual variability. High

OBJECTIVE—To examine the effects of dipeptidyl peptidase-IV (DPP-4) inhibition on meal-related β-cell function and insulin sensitivity over 52 weeks in type 2 diabetes. RESEARCH DESIGN AND METHODS—In a 12-week core study, placebo (n = 51) or vildagliptin (n = 56; 50 mg OD) was added to metformin treatment (1.5–3.0 mg/day). A 40-week extension followed in 71 patients. Meal tests were performed at

Glacifluvial deposits along an ice-marginal zone,in Smaland, southern Sweden, have been dated using post-IR blue OSL. To test for incomplete bleaching, we adopted two strategies: analysis of modern analogues and small-aliquot dose distributions. Samples of modern fluvial sediments show no significant incomplete bleaching; they yield equivalent doses of only 0.5-2 Gy (similar to 0.25-4% of our glac

The search for planets around white dwarf stars, and evidence for dynamical instability around them in the form of atmospheric pollution and circumstellar disks, raises questions about the nature of planetary systems that can survive the vicissitudes of the asymptotic giant branch (AGB). We study the competing effects, on planets at several AU from the star, of strong tidal forces arising from the

In the literature, there are several different suggestions as to when the first postoperative pin-site care should be carried out to best prevent pin-site infections during the treatment by external fixation. In a cohort study, we compared the use of antibiotics and complications in patients where the theatre dressing was changed during the first postoperative week with patients where the theatre

Recent investigations-of the interaction between DNA and alkyltrimethyl ammonium bromides of various chain lengths are reviewed. Several techniques have been used such as phase map determinations, fluorescence microscopy, and electron microscopy. Dissociation of the DNA-surfactant complexes, by the addition of anionic surfactant, has received special attention. Precipitation maps for DNA-cationic

BACKGROUND: It is generally argued that variations in cerebral blood flow create concomitant changes in the cerebral blood volume (CBV). Because nitrous oxide (N(2)O) inhalation both increases cerebral blood flow and may increase intracranial pressure, it is reasonable to assume that N(2)O acts as a general vasodilatator in cerebral vessels both on the arterial and on the venous side. The aim of t

The Src-Like Adaptor Protein (SLAP) is an adaptor protein sharing considerable structural homology with Src. SLAP is expressed in variety of cells regulating receptor tyrosine kinase signaling by direct association. In this report, we show that SLAP associates with both wild-type and oncogenic c-Kit (c-Kit-D816V). The association involves SLAP SH2 domain and receptor phosphotyrosine residues diffe

Market-driven software development companies experience challenges in requirements management that many traditional requirements engineering methods and techniques do not acknowledge. Large markets, limited contact with end users, and strong competition forces the market-driven software development company to constantly invent new, selling requirements, frequently release new versions with an acco

What mechanisms are needed in a cognitive system, such as an animal or a robot, and how do these mechanisms interact with each other? The thesis presents a study of this problem within the field of behavior-based systems and artificial neural networks. The thesis brings together ideas from behavior-based robotics, control theory and machine learning and combines them with models from ethology, ps

Temperate and boreal forests in the Northern Hemisphere cover an area of about 2 times 107 square kilometres and act as a substantial carbon sink (0.6–0.7 petagrams of carbon per year)1. Although forest expansion following agricultural abandonment is certainly responsible for an important fraction of this carbon sink activity, the additional effects on the carbon balance of established forests of

Vilka möjligheter har en efterlevande sambo vid sin sambos bortgång att bibehålla det gemensamma hemmet intakt? Möjligheterna för den efterlevande sambon varierar beroende på om denne omfattas av antingen den svenska rätten eller grannlandet Norges rättsordning, vilket ger upphov till intressanta frågeställningar om skillnaderna länderna emellan. Den svenska rätten grundar sig i en utgångspunkt What are the possibilities for a surviving cohabitant to keep the mutual home undivided? The possibilities, which the surviving cohabitant has, varies depending on whether he or she is covered by Swedish law or by the law of the neighboring country Norway. This leads to interesting questions on the differences between the regulations in the two countries. The Swedish legal system is based on a s

This thesis presents and evaluates nineteen methods for combining up to eleven automated univariate forecasts. The evaluation is made by applying the methods on a dataset containing more than 1000 monthly time series. The accuracy of one period ahead forecasts is analyzed. Almost 3.2 million forecasts are evaluated in the study. Methods that are using past forecasts to optimally produce a combined

I uppsatsen utreds vilken bevisbörderegel som i ett tvistemål om olovlig fildelning ska utformas för fastställandet av intrångsgöraren i 54 § i lag (1960:729) om upphovsrätt till litterära och konstnärliga verk. Den huvudsakliga frågeställningen besvaras utifrån situationen där rättighetsinnehavaren, till det fildelade upphovsrättsliga verket, riktar skadeståndsanspråk mot abonnenten av den internThis thesis investigates which burden of proof rule that, in a civil case concerning illegal file sharing, should be designed for the determination of the infringer in Article 54 in the Swedish Copyright Act (1960:729). The main issue is answered based on the situation where the right holder, to the file-shared copyright work, directs claims against the subscriber of the internet connection which

Under hösten 2016 utlystes en sluten arkitekttävling om ett nytt kulturhus Bergsjön. Bergsjön är en stadsdel i utkanten av nord-östra Göteborg. Många upplever området som isolerat från resten staden både fysiskt och socialt. Bebyggelsen, som i stort sett är helt intakt från 60-och 70-talet, speglar de dåvarande idealen och bjuder på såväl möjligheter som utmaningar. Samtidigt ligger stadsdelen i mDuring the fall in 2016 the city of Gothenburg announced a competition for a new house of culture located in Bergsjön. Bergsjön is a district in the north east part of the city. A lot of people view the area as isolated from the rest of the city, both physically and socially. The near intact development from the 60s and 70s, reflect the ideals of the time which means both great possibilities and c