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Förenligheten mellan ISDS-mekanismen i Artikel 26 i Energistadgefördraget (ECT) och EU rätt har länge varit föremål för diskussion inom EU. Denna diskussion har de senaste åren fått all mer uppmärksamhet, sedan EUdomstolen i mål C-284/16 Achmea dömde att ISDS-mekanismen i det bilaterala investeringsavtalet (BIT) mellan Nederländerna och Slovakien var oförenligt med EU rätten. Enligt kritikerna gårThe compatibility of the investor-State dispute settlement (ISDS) mechanism in Article 26 of the Energy Chart Treaty (ECT) with EU law has been a topic of intense discussion within the EU for a number of years. This discussion has gained traction in the light of the CJEU’s judgement in Case C-284/16 Achmea, where the Court declared that ISDS mechanism in the Bilateral Investment Treaty (BIT) betwe

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Video capsule endoscopy (VCE), perfomed by ingesting a small vitamin-sized camera pill, was developed over a period of a couple of decades and –since its introduction in clinical practice at the dawn of the millennium– has become an essential tool in the diagnosis and management of small bowel (SB) diseases. At the same time, other fields such as minimally invasive diagnosis of other parts of the

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To study the association between lifestyle and biological risk markers measured at one occasion, morbidity and mortality from cardiovascular disease (CVD) and cancer, and morbidity from diabetes approximately 26 years later.

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Neuropsychiatric Symptoms (NPS) have been shown to be associated with Alzheimer's disease ( AD). They negatively affect disease outcome and could play a future role in the detection of prospective AD cases. In the present study we aimed at examining the rel ation between NPS and Amyloid beta ( in both a cognitively healthy N = and cognitively impaired N = 224) dataset from the Swedish BioFINDE

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Diagnostic measurement of electric skin conductivity (ESC) called the Ryodoraku system was introduced in mid 1950s by Nakatani. As has been shown by Ziobro et al. in case of infantile cerebral palsy, changes of ESC may provide a valuable electrophysiological parameter for monitoring a therapy. In this study ESC was measured in asthmatic children treated with a bioelectronic unit VEGA-SELECT. Analy

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Background: Systemic Lupus Erythematosus (SLE) is an autoimmune disease encompassing a wide range of symptoms that can emanate from pathology in virtually any organ system. Severe SLE includes involvement of the central nervous system and kidneys. One of the hallmarks of the disease is a multitude of autoantibodies, indicating a breakdown in self tolerance. The corresponding antigens have been fou

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Pyranose 2-oxidase (P20x) has several proposed biotechnological applications such as a bio-component in biofuel cells or for carbohydrate transformations. To improve some of the catalytic properties of P20x from Trametes multicolor, we selected a semi-rational approach of enzyme engineering, saturation mutagenesis of active-site residues and subsequent screening of mutant libraries for improved ac

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Streptococcus pyogenes infects over 700 million people worldwide annually. Immune evasion strategies employed by the bacteria include binding of the complement inhibitors, C4b-binding protein (C4BP) and Factor H in a human-specific manner. We recently showed that human IgG increased C4BP binding to the bacterial surface, which promoted streptococcal immune evasion and increased mortality in mice.

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Presented here is an engineered protein domain, based on Protein A, that displays a calcium-dependent binding to antibodies. This protein, ZCa, is shown to efficiently function as an affinity ligand for mild purification of antibodies through elution with ethylenediaminetetraacetic acid. Antibodies are commonly used tools in the area of biological sciences and as therapeutics, and the most commonl