Filtyp
Current hemophilia B treatment guidelines recommend routine prophylaxis with factor IX (FIX) replacement products, tailored to maintain plasma activity at levels that will prevent bleeds. However, plasma FIX activity may not be the primary determinant or best indicator of hemostatic efficacy due to its extravascular distribution. FIX replacement therapy has evolved to include extended half-life (E
The collapse of the Soviet Union in 1991 has been a turning point in the World history that left a unique footprint on the Northern Eurasian ecosystems. Conducting large scale mapping of environmental change and separating between naturogenic and anthropogenic drivers is a difficult endeavor in such highly complex systems. In this research a piece-wise linear regression method was used for breakpo
Over the past few years, wireless mesh networks are emerging as a strong technology for cheap wireless coverage. Despite recent advances in wireless mesh networking, many research challenges remain in all protocol layers. Since a mesh network usually has very different characteristics than those of current fixed mobile networks, traditional fixed deployments such as those in cellular IP and HMIP w
Protein kinase C (PKC) plays a prominent role in immune signaling, and the paradigms for isoform selective signaling are beginning to be elucidated. Real-time microscopy was combined with molecular and biochemical approaches to demonstrate a role for PKC-epsilon in Fcgamma receptor (FcgammaR)-dependent phagocytosis. RAW 264.7 macrophages were transfected with GFP-conjugated PKC isoforms, and GFP m
Platelets express Toll-like receptor 4 (TLR4), and this has been shown to be responsible for the thrombocytopenia induced by lipopolysaccharide (LPS) administration in vivo. We studied the role of LPS in mediating platelet phagocytosis by THP-1 cells in vitro by flow cytometry. Opsonization of platelets with an IgG monoclonal (W6/32) antibody or with IgG autoantibody-positive sera from patients wi
The sports industry is one of the most challenging and constantly evolving industries, yet simultaneously, the smaller and medium-sized clubs face a severe challenge of competing against the biggest and best-known brands in the world. The sports literature is limited to marketing and studying global mega-brands; this thesis addresses the gap in strategic management literature concerning both sport
Syftet med denna studie var att undersöka psykodynamiska psykoterapeuters subjektiva upplevelser och erfarenheter av vändpunkter i psykoterapi. Detta gjordes med en kvalitativ fenomenologisk-hermeneutisk ansats, med Tematisk analys som metod. Sex psykodynamiska psykoterapeuter och två som befann sig under utbildning till psykoterapeut intervjuades, och en psykoterapeut valde att skriva ner sin ber
We demonstrate that exceptional points exist in fully transparent, optically "effectively" biaxial, anisotropic micro-cavities, fabricated using an uniaxial cavity material with its axis inclined to the Bragg mirror growth direction. This is similar to the existence of singular (optic) axes in absorbing biaxial crystals, but the lack of time reversal symmetry is mediated by the mode broadening, i.
Cytological analysis of a series of Streptomyces coelicolor A3(2) mutants with disruptions of early sporulation (whi, for white aerial mycelium) genes in an isogenic background has provided new information about the role of whiH, and confirmed and extended previous knowledge about whiG, whiA and whiB. The characteristic straight aerial hyphae of whiG mutants contained normally spaced vegetative-li
The globally widespread kind of description of vowels by points in the IPA quadrangle with the cardinal vowels as references is very often not trustworthy in its detailed specification. The reasonable interpretation of a dot registration is namely that the vowel quality is very narrowly pinpointed. However, most phoneticians do not have the capacity to judge vowels in this detailed way. Consequent
This thesis consists of four papers that broadly concerns two dierent topics. The rsttopic is so-called barycentric Markov processes. By a barycentric Markov process wemean a process that consists of a point/particle system evolving in (discrete) time,whose evolution depends in some way on the mean value of the current points in thesystem. In common for the three rst papers which are on this topic
The purpose of dynamic asset allocation (DAA) is to overcome the challenge that changing market conditions present to traditional strategic asset allocation by adjusting portfolio weights to take advantage of favorable conditions and reduce potential drawdowns. This article proposes a new approach to DAA that is based on detection of change points without fitting a model with a fixed number of reg
