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Estrogens are sex hormones that are central to health and disease in both genders. These hormones have long been recognized to act in complex ways, both through relatively slow genomic mechanisms and via fast non-genomic mechanisms. Several recent in vitro studies suggest that GPR30, or G protein-coupled estrogen receptor 1 (GPER1), is a functional membrane estrogen receptor involved in non-genomi
PURPOSE: It is difficult to definitively rule out or establish malignancy pre-operatively in patients with adrenal lesions referred for adrenal surgery. The aim of this study was to identify risk factors for a malignant diagnosis in patients treated with adrenalectomy. METHODS: Consecutive adrenalectomies at the Department of Surgery, Lund University Hospital between 2000 and 2009 were identified.
Context: Pediatric cancer treatment may imply an increased risk of hypogonadism, leading to metabolic disorders and osteoporosis. Such complications are potentially preventable. Objective: The aim of this study was to assess diagnosis- and treatment-dependent risk of hypogonadism in male childhood cancer survivors (CCS). Design: Male CCS who were treated during the period 1970-2002 and who in 2004
Objectives: Knowledge of the societal costs of psoriasis is limited. This study estimated the cost of care, psoriasis area and severity index (PASI), and quality of life in a defined patient population in Sweden. Methods: A prevalence-based prospective recruitment of patients visiting two Swedish dermatology clinics between September and December 2009 was performed, collecting resource utilization
Wave propagators are introduced for transient wave propagation in a general one-dimensional medium. The definition of wave propagators is based upon a wave splitting technique. Several properties for the propagators are given and the relations between the method of propagators and the invariant imbedding method and the Green function approach are discussed.
Cloud computing is an application hosting model providing the illusion of infinite computing power. However, even the largest datacenters have finite computing capacity, thus cloud infrastructures have experienced overload due to overbooking or transient failures. The topic of this paper is the comparison of different control strategies to mitigate overload for datacenters, that assume that the r
We measured angular distributions of recoil-polarization response functions for neutral pion electroproduction for W=1.23 GeV at Q2=1.0 (GeV/c)2, obtaining 14 separated response functions plus 2 Rosenbluth combinations; of these, 12 have been observed for the first time. Dynamical models do not describe quantities governed by imaginary parts of interference products well, indicating the need for a
This article offers a new perspective on the use of ritual and tradition in contemporary Sweden. Urbanization, immigration, cultural pluralism, the capitalist market system, changing conditions for women, the influence of mass media, and individualism are all characteristic of the social condition of modernity that have radically changed the context of ritual and transformed traditional patterns.
The paper is concerned with coordinate representations for rigid parts in multibody dynamics. The discussion is based on the general theory of the dynamics of multibody systems under constraints. General configuration coordinates are introduced and the requirement of their regularity is discussed. The use of Euler angles, quaternions and linear coordinates, where quaternions and linear coordinates
Acoustic fatigue can occur in structural elements of an aircraft exposed to very high sound pressures. To deal with acoustic fatigue, mainly empirical methods have been applied and often late in the design phase. Current design guidelines have several limitations. First, they do not say anything about the load intensities. The load levels can be determined either experimentally or numerically. Exp
