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Gene fusions arising from translocations make an important contribution to the development of cancer. A new study uses high-throughput sequencing to characterize such fusions at an unprecedented level of resolution.

In the search for the fully aligned 27(-) state in Nd-140 predicted by cranked Nilsson-Strutinsky calculations, new close-to-spherical high-spin states have been discovered. Both the close-to-spherical and the triaxial calculated states are in good agreement with the experimental results, supporting the existence of shape coexistence up to very high spins. Shell-model calculations using a newly de

OBJECTIVES: Our goal in this study was to explore the use of a hybrid approach to calculate benchmark doses (BMDs) and their 95% lower confidence bounds (BMDLs) for renal effects of cadmium in a population with low environmental exposure. METHODS: Morning urine and blood samples were collected from 820 Swedish women 53-64 years of age. We measured urinary cadmium (U-Cd) and tubular effect markers

The introduction of pentose utilization pathways in baker's yeast Saccharomyces cerevisiae is summarized together with metabolic engineering strategies to improve ethanolic pentose fermentation. Bacterial and fungal xylose and arabinose pathways have been expressed in S. cerevisiae but do not generally convey significant ethanolic fermentation traits to this yeast. A large number of rational metab

Popular Abstract in Swedish Riskanalys och insatsplanering är viktiga delar av ett riskhanteringsarbete. Denna studie har visat att det är möjligt att använda brandtekniska ingenjörsmodeller för att bedöma utvecklingen av bränder och det uppkomna behovet av släckmedel. Brandkårsdata från London användes för att studera sambandet mellan brandstorleken och räddningstjänstens insats. Dessa data, tillRisk analysis and intervention planning are important in fire prevention and risk management strategies. This study has shown that it is possible to use fire safety engineering models to estimate the development of fires on a realistic scale, and the corresponding requirement for extinguishing media. Data from the London Fire Brigade (UK) were used to investigate a possible correlation between the

Wave propagators are introduced for transient wave propagation in a general one-dimensional medium. The definition of wave propagators is based upon a wave splitting technique. Several properties for the propagators are given and the relations between the method of propagators and the invariant imbedding method and the Green function approach are discussed.

Christina Stead's works resist simplistic categorization, a circumstance which has attracted some critics and exasperated many others. The upsurge of post-colonial and feminist criticism in the 1980s revitalized critical interest in her books. Exuberant intertextuality and an abundance of contradictory literary and ideological discourses - previously often regarded as excesses flawing Stead's lite

Three-dimensional boundary finding based on Fourier surface optimization is presented as a method for segmentation of SPECT images. Being robust against noise and adjustable with respect to its detail resolution, it forms an interesting alternative in this application area. A three-dimensional approach can also be assumed to increase the possibility of delineating low contrast regions, as compared

In this grounded theory study, the authors analyze interviews and participant observation data related to palliative cancer nursing in hospitals. Striving for Emotional Survival emerged as the pattern of behavior through which nurses deal with their main concern, the risk of being emotionally overloaded by their work. It involved three main strategies: Emotional Shielding through Professional Shie

A terminating rotational band has been identified in Mn-51 following the Si-28(S-32,2alpha1p)Mn-51 fusion-evaporation reaction at 130 MeV beam energy. Spins and tentative positive parities of the band members are assigned based on angular distribution and correlation measurements of transitions, which connect the rotational structure with previously known yrast states. Configuration-dependent cran

Policy proposals for the management of water resources need to take into account two emerging themes: public involvement in the development of resource use policy and water management on a catchment level. The CATCH-model, a decision support system for catchment-based water management, builds on the use of ‘discourse and deliberation’ within stakeholder groups to define relevant socio-economic par

Indications of what the tour-operating sector considers to be 'good practice' can be drawn from voluntary initiatives such as existing eco-labels and codes of conduct. However, practical implementation of such guidance varies greatly from one tour operator to another, depending on different types of factors, such as size, financial capacity, corporate structure, operational location, organizationa

The biologic evaluation in living rats of 68Ga-labeled oligonucleotides as imaging agents for PET is reported. Methods: 68Ga, a positron-emitting radionuclide (half-life, 68 min), along with a macrocyclic chelating agent, 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetic acid (DOTA), was used for labeling of antisense oligonucleotides targeting activated human K-ras oncogene. The biologic p

Popular Abstract in Swedish Avhandlingen handlar om tes av periodicitet och trend inom långminne-processer. Med hjälp av diskret wavelet transform och periodogram presenteras vi två test för periodicitet och tre test för trend. Vi utvärderar vår test samt studerar deras egenskaper delvis genom att använda oss av datorintensiva metoder såsom Monte Carlo och delvis genom att jämföra dem med andra liThis thesis presents methods of testing the periodicity and trend for the time series, which exhibit dependence over long periods of time. Many such processes can be modeled by a class of models called fractionally differenced processes. The first approach we consider to analyse such processes is by using the band periodogram, which divides the periodogram into different intervals or bands, matchi

The fragmentation of a 550MeV/u primary beam of Ni-58 on a Be-9 target has been used to measure time-and energy-correlated gamma decays following the implantation of event-by-event discriminated secondary fragments into a Be-9 stopper plate. A new isomeric gamma decay with T-1/2 = 14(6 4) ns and E-gamma = 646.2(2) keV is observed and attributed to the decay of the yrast 3/2-state in Co-53(27)26. T

The Barany Society Ad Hoc Committee on Vestibular Rehabilitation Therapy has developed guidelines for developing educational programs for continuing education. These guidelines may be useful to individual therapists who seek to learn about vestibular rehabilitation or who seek to improve their knowledge bases. These guidelines may also be useful to professional organizations or therapists who prov

The IWA Anaerobic Digestion Model No. 1 (ADM1) was presented in 2002 and is expected to represent the state-of-the-art model within this field in the future. Due to its complexity the implementation of the model is not a simple task and several computational aspects need to be considered, in particular if the ADM1 is to be included in dynamic simulations of plant-wide or even integrated systems. I

Several poly (dimethylsiloxanes) (PDMS) copolymers of dimethylsiloxane (DMS) with ethylene or propylene oxide were tested as artificial carriers for the delivery of oxygen to biological systems. Copolymers with a DMS content of 33% or lower enhanced glucose oxidation by 200% in contrast to the 25% increase produced by the same concentration of perfluorodecalin. When 0.05% of the copolymer with 18%