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Background: Detecting pancreatic cancer at an earlier stage may contribute to an increased survival. Patients with stage I pancreatic cancer have a 5-year survival rate of 36%, while stage IV patients have a 5-year survival rate of 1% in Sweden. Research into novel blood-based biomarkers for pancreatic cancer is highly intensive and innovative, but has yet to result in any routine screening test.
Transcript alterations often result from somatic changes in cancer genomes1. Various forms of RNA alterations have been described in cancer, including overexpression2, altered splicing3 and gene fusions4; however, it is difficult to attribute these to underlying genomic changes owing to heterogeneity among patients and tumour types, and the relatively small cohorts of patients for whom samples hav
Moving forward, higher education will face a variety of challenges, especially in 2020/2030, due to technological development and digitalization. Digitalization in society has grown, and society fosters digital citizenship to a greater extent. Students entering higher education today have grown up with the Internet and mobile devices. Daily life, schools, and work have also become more mobile beca
Migrants as a group are recognised as being at risk of receiving low retirement pensions. Income over a lifetime is the principle for calculating pension rights. We have interviewed a group of migrants about their retirement preparations. Our results show that there are obstacles that obstruct migrants from entering the Swedish labour market, which will greatly influence future pensio
Radio-over-copper is a niche idea that has potential to become a cornerstone in the deployment of dense 5G networks. We address one of the remaining hurdles and present an architecture for transparent crosstalk mitigation in LTE-over-copper systems. By taking advantage of reference symbols present in the downlink LTE signals we propose two methods for estimating the copper channel. System performa
PURPOSE: Anticipation (ie, an earlier age at onset in successive generations) is linked to repeat expansion in neurodegenerative syndromes, whereas its role in hereditary cancer is unclear. We assessed anticipation in Lynch syndrome (hereditary nonpolyposis colorectal cancer [HNPCC]), in which DNA mismatch repair (MMR) defects cause early and accelerated tumor development with a broad tumor spectr
Microdosing is a new concept in drug development that-if implemented in the pharmaceutical industry-would mean that new drugs can be tested earlier in humans than done today. The human microdosing concept-or 'Phase 0'-may offer improved candidate selection, reduced failure rates in the drug development line and a reduction in the use of laboratory animals in early drug development, factors which w
In the context of an international trend of claims for historical justice, several aspects of Swedish contemporary history were re-evaluated in the 1990s. One of the most well-known examples is the heated political and scholarly debate on involuntary sexual sterilization, sparked by a series of critical newspaper articles in August 1997 that attracted international media attention and resulted in
Adding hydrogen atoms and protonation states to structures of membrane proteins requires successful implementation of neutron macromolecular crystallography (NMX). This information would significantly increase our fundamental understanding of the transport processes membrane proteins undertake. To grow the large crystals needed for NMX studies requires significant amounts of stable protein, but on
We conduct what we believe to be the most methodologically rigorous study of mood effect in the field so far to measure its economic impact and address shortcomings in the existing literature. Using a large dataset containing over 46 million car inspections in Sweden and England in 2016 and 2017, we study whether inspectors are more lenient on days when their mood is predicted to be good, and if c
Background: Peripartum asphyxia affects three to five per 1000 live births, with moderate or severe hypoxic ischemic encephalopathy (HIE) occurring in 0.5 to 1 per 1000 live births, and is associated with high mortality and morbidity. Therapeutic hypothermia is an effective treatment, but alternative therapies such as acupuncture are also used. Objectives: To determine the benefits and harms of ac
BACKGROUND: Children often require pain management following surgery to avoid suffering. Effective pain management has consequences for healing time and quality of life. Ibuprofen, a frequently used non-steroidal anti-inflammatory drug (NSAID) administered to children, is used to treat pain and inflammation in the postoperative period.OBJECTIVES: 1) To assess the efficacy and safety of ibuprofen (
Urban densification is a way of accommodating population growth. Land adjacent to railways is used for constructing residences and other buildings, and new tramway systems are planned. Under these circumstances, nearby buildings will be exposed to vibrations and noise that may become a nuisance for the residents. It is necessary, even at an early stage of planning, to assess the extent of the vibr
According to the Swedish higher ordinance of education the development of autonomy of PhD students is of high importance. Graduates should be able to formulate new ideas and to independently assess and evaluate scientific results. Therefore it is interesting to investigate how the relationship between student and supervisor impacts the development of autonomy. In this work, we have evaluated the i
