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BACKGROUND: Postmastectomy radiotherapy was shown in previous meta-analyses to reduce the risks of both recurrence and breast cancer mortality in all women with node-positive disease considered together. However, the benefit in women with only one to three positive lymph nodes is uncertain. We aimed to assess the effect of radiotherapy in these women after mastectomy and axillary dissection.METHOD
Introduction: Evidence for gut–kidney interactions in early kidney disease is limited, particularly in community-dwelling adults with largely preserved kidney function. Here, we quantified links between gut microbiota and estimated glomerular filtration rate (eGFR) in two population-based Swedish cohorts. Methods: Deep shotgun metagenomics profiled fecal samples from 9788 adults in the Swedish CAr
Rapid urban growth is making cities hotter, a trend further exacerbated by climate change. Urban green spaces (UGS) are commonly used as nature-based solutions to reduce heat, but there are gaps in understanding how cooling effects vary across climate zones. Using satellite data from 2021 to 2024, we examined urban heat and UGS patterns during the hot season across four Ethiopian cities with diffe
BACKGROUND: Excessive dietary salt intake is associated with elevated blood pressure and damage to organs including the heart, vasculature, and kidneys. Women are more prone to salt-sensitive hypertension, yet preclinical studies often focus on men.METHODS: To examine sex-specific responses to chronic salt loading, male and female C57Bl6/J mice were fed a high-salt diet (HSD; 8% NaCl) from 7 to 14
Animals live in diverse environments and have evolved to cope with environmental challenges in different ways. How such adaptations shape overall brain morphology is still unclear. Here, we test how two behavioural adaptations – circadian activity pattern and migratory behaviour – are reflected in the brains of moths and butterflies (Lepidoptera). We predicted that circadian activity pattern affec
Despite the importance of the gut microbiome to health, the role of human genetic variation in shaping its composition remains poorly understood. Here we report genome-wide association analyses of harmonized metagenomic data from 16,017 adults in four Swedish population-based studies, with replication in 12,652 people from the Norwegian HUNT study. We identified variants in the OR51E1–OR51E2 locus
Process-based land surface models are important tools for estimating global wetland methane (CH4) emissions and projecting their behavior across space and time. So far there are no performance assessments of model responses to drivers at multiple time scales. In this study, we apply wavelet analysis to identify the dominant time scales contributing to model uncertainty in the frequency domain. We
This paper presents a search for hypothetical massive, charged, long-lived particles with the ATLAS detector at the LHC using an integrated luminosity of 139 fb−1 of proton–proton collisions at s = 13 TeV. These particles are expected to move significantly slower than the speed of light and should be identifiable by their high transverse momenta and anomalously large specific ionisation losses, dE
Objectives The aim of this research is to study education, income and immigration as risk factors for high hemoglobin A1c (HbA1c >70 mmol/mol (8.6%)) when diagnosed with type 2 diabetes (T2D) or latent autoimmune diabetes in the adult (LADA). Research design and methods Patients were included from the All New Diabetics in Scania study (2008-2013). Level of education, disposable income and immigrat
BACKGROUND: Summary measures of health are essential in making estimates of health status that are comparable across time and place. They can be used for assessing the performance of health systems, informing effective policy making, and monitoring the progress of nations toward achievement of sustainable development goals. The Global Burden of Diseases, Injuries, and Risk Factors Study 2015 (GBD
Summary: Osteoporotic fractures may pose a challenge for skeletal regeneration. This study investigates if pharmaceutical interventions such as bone morphogenetic protein 7 (BMP-7) alone or in combination with Zoledronate have equivalent efficacy in osteoporotic bone? Our findings suggest they do and that an osteoporotic bone environment may increase sensitivity to BMP-7. Introduction: Osteoporosi
I september 2014 infördes en ny korsningstyp, cykelöverfart, där fordonstrafik som korsar cykelöverfarten har väjningsplikt mot cyklande och mopedförare som är på eller just på väg ut på cykelöverfarten. Syftet med projektet är att utvärdera regleringsformens effekt på cyklisters trafiksäkerhet. På tre platser i Malmö studerades hastigheter, allvarliga konflikter, väjningsbeteende samt interaktion
Objective Based on clinical experience gained over many years, the maximal haemostatic effect following administration of local anaesthetics containing epinephrine is generally believed to occur within 10 minutes. Surprisingly, it was found in a recent study, in which bleeding was quantified intraoperatively, that maximal haemostasis did not occur until 30 minutes. If this is indeed the case, the
A search for supersymmetry in events with large missing transverse momentum, jets, and at least one hadronically decaying τ-lepton is presented. Two exclusive final states with either exactly one or at least two τ-leptons are considered. The analysis is based on proton-proton collisions at s=13 TeV corresponding to an integrated luminosity of 36.1 fb-1 delivered by the Large Hadron Collider and re
A search for heavy right-handed Majorana or Dirac neutrinos N R and heavy right-handed gauge bosons W R is performed in events with a pair of energetic electrons or muons, with the same or opposite electric charge, and two energetic jets. The events are selected from pp collision data with an integrated luminosity of 36.1 fb −1 collected by the ATLAS detector at s=13 TeV. No significant deviations
The two-photon absorption (TPA) properties of β-carotene (beta-carotene) in chloroform solution were investigated over the 590-790 nm wavelength range. The TPA was characterized using the open-aperture z-scan technique with picosecond pulses provided by a widely traveling-wave optical parametric amplifier (OPA) pumped with a Ti:sapphire laser amplifier. We found the 0.2-1 cm/GW values of two photo
In this paper, I describe systems and prototypes we created in the natural language processing group at Lund to extract structured knowledge from text. Starting from syntactic and semantic parsingcomponents,wedevelopedapplicationsthatcanhandlelargecorpora,typicallycomplete Wikipedia versions consisting of millions of documents and process text to identify entities and the relations between them. I
