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Objectives We aimed to describe clinical and diagnostic characteristics of primary care patients with heart failure and physicians’ adherence to guideline-directed medical therapy (GDMT) for treating chronic heart failure. Design Cross-sectional study based on baseline data from the prospective primary care-based study Heart failure in Southern Sweden (HISS). Setting Patients with heart failure we
Ongoing global change is leading to the widespread redistribution of species1,2. Assessments of shifts in species geographic ranges, however, remain taxonomically biased and geographically limited2, especially for insects. We conducted a global synthesis on butterfly range shifts using a combination of multi-lingual review in 15 languages and expert assessments, compiling data on range shifts for
Genetic variation at the MTIF3 (Mitochondrial Translational Initiation Factor 3) locus has been robustly associated with obesity in humans, but the functional basis behind this association is not known. Here, we applied luciferase reporter assay to map potential functional variants in the haplotype block tagged by rs1885988 and used CRISPR-Cas9 to edit the potential functional variants to confirm
The Syrian civil war has been described as a first example of the conflicts expected in the wake of climate change. The conflict, which started in 2011, was preceded by a severe drought in 2007–2009 that hit agriculture and the rural population hard. But what do we really know about what happened to Syria’s climate and agriculture before and after the start of the conflict? In this article, I summ
Several extensions of the Standard Model predict the production of dark matter particles at the LHC. A search for dark matter particles produced in association with a dark Higgs boson decaying into W+ W− in the ℓ±νqq¯′, final states with ℓ = e, μ is presented. This analysis uses 139 fb −1 of pp collisions recorded by the ATLAS detector at a centre-of-mass energy of 13 TeV. The W± → qq′ ¯ decays ar
Rural perspectives in political debates are often dismissed as sentimental, narrowly self-interested, and irrational. This paper reports findings that challenge this view. Applying a deliberative systems approach, it examines how rural perspectives are articulated in Swedish public discourse. It identifies four coherent discourses that promote distinct political values: economic growth, rural cons
This article draws on usability evaluations of a behavioural change intervention delivered as a web-based course. Special attention was given to usability as the course is directed at older adults aged 70 and above. Experiences from the usability evaluations in a lab environment and the real world, followed by stepwise refinements, can serve as examples of what must be considered in developing cou
Established ecological theory has focused on unitary organisms, and thus its concepts have matured into a form that often hinders rather than facilitates the ecological study of modular organisms. Here, we use the example of filamentous fungi to develop concepts that enable integration of non-unitary (modular) organisms into the established community ecology theory, with particular focus on its sp
In post-peace agreement Colombia, everyone declared war on the forest. In the Putumayo region, these wars take their own particular forms. Scientifically, the Putumayo is described as an Andean-Amazonic rainforest. For the indigenous and local inhabitants of the Putumayo, it is the Andean-Amazonic selva. We present three wars on the forest with material and discursive specificities and critically
OBJECTIVE: We investigated whether prepregnancy BMI (prePregBMI) in women with obesity was associated with differential DNA methylation (DNAm) in cord blood (CB) and whether DNAm may mediate the association of prePregBMI and early childhood BMI z score (BMIz).METHODS: From the Treatment of Obese Pregnant Women (TOP) study, 232 mother-child pairs were included. We conducted an epigenome-wide associ
INTRODUCTION: Ageing right care(fully) is a transnational research study which explores and maps an understanding of the care pathways between ageing in place and hospital at home policy and practices for older adults in Israel, the Netherlands and Sweden. The countries are suited to be compared where they have growing, ageing populations, a focus on healthcare reform and several policies to reduc
Background and aims: The N-terminal propeptide of type III collagen (PRO-C3) assay measures a pro-peptide released during type III collagen synthesis, an important feature of arterial stiffening and atherogenesis. There is a clinical need for improved non-invasive, cheap and easily accessible methods for evaluating individuals at risk of cardiovascular disease (CVD). In this study, we investigate
Production of agricultural biofuels is expected to rise due to increasing climate change mitigation ambitions. Policy interventions promoting targeted bioenergy solutions can be motivated by the large environmental externalities present in agricultural systems and the local context of biomass production co-benefits. Introducing energy crops in crop rotations in arable land with depleted Soil Organ
We study an extended bootstrap percolation process in several steps in dimension one, assuming noncyclic boundary conditions. We study the asymptotic behavior of the process as the size of the underlying graph goes to innity. We nd a phase transition with respect to the initial conditions. The phase diagram on the set of initial conditionals of the extended process is described completely. This pr
Förenta Nationernas Ekonomiska Kommission för Europas Konvention om tillgång till information, allmänhetens deltagande i beslutsprocesser och tillgång till rättslig prövning i miljöfrågor (Århuskonventionen) anses vara det essentiella rättsligt bindande instrumentet för skyddet av allmänhetens miljörelaterade rättigheter. Konventionen bygger på uppfattningen att processuella rättigheter i samband The United Nation Economic Commission for Europe’s Convention on access to information, public participation in decision-making, access to justice in environmental matters (hereafter the Aarhus Convention) is considered to be the main legally binding instrument protecting the public’s environmental rights. It is based on the idea that procedural rights relating to environmental matters should cont
I EU-rätten finns många versioner av ne bis in idem. De återfinns inte minst i huvudkällorna till mänskliga rättigheter i unionen: EU:s allmänna principer, stadgan om de mänskliga rättigheterna och Europakonventionen, men också i konventionen om tillämpning av Schengenavtalet och många andra regelverk. Denna uppsats berör frågan huruvida det ändå finns en enda, sammanhållen ”kärn”-förståelse av neThere are many versions of ne bis in idem in EU law. They can be found not least in the main sources of human rights of the EU legal order: the general principles of EU law, the Charter of Fundamental Rights, the European Convention on the Protection of Human Rights and Fundamental Freedoms, but also in the Convention Implementing the Schengen Agreement and many other bodies of law. This essay add
Following World War Two emigration from Central and Eastern Europe, in particular, has grown in spite of increasingly strict border controls. Given this rise in migration pressure from the East during a strictly regulated period, the 2004 EU enlargement of Cyprus, Czech Republic, Estonia, Hungary, Latvia, Lithuania, Malta, Poland, Slovakia, and Slovenia threatened to transform the migration landsc
This case study researches why the Swedish region Västra Götaland fails to implement the environmental aim to achieve only natural acidification. The study is based on implementation theory and is operationalized by interviews with authorities and text analysis. In conclusion this study finds that the natural condition of the environment in Västra Götalands län has a large impact on the result of
