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This thesis includes two different parts: One focusing on how to induce human embryonic stem cells (hESCs) to differentiate into insulin producing cells by following the normal pancreatic development pathway. These cells have then the potential to be an unlimited source for diabetes regenerative medicine. The second part of the thesis deals with how embryonic stem cells rid themselves of damaged p

Cellobiose dehydrogenase (CDH) is a sugar oxidizing enzyme secreted by various species of wood degrading fungi to assist the process of wood degradation. It can oxidise analytically relevant sugars as cellobiose, lactose or glucose leading to a gain of two electrons per sugar molecule. CDH consists of a flavin containing catalytic domain (DH) and a haem containing electron mediating domain (CYT).

Popular Abstract in Swedish Populärvetenskaplig sammanfattning Hyaluronan (hyaluronsyra) är en högmolekylär polysackarid som förekommer i all biologisk vävnad i olika koncentrationer, med särskilt höga nivåer i bindväv. Den kan bildas av de flesta celltyper. På molekylär nivå föreligger den i form av ett nystan, har förmågan att binda stora mängder vatten, och har en uttalad pseudoplasticitet. HyaHyaluronan has been found in the eye in varying amounts and at different sites. It is involved in physiological and pathological processes, though many aspects of its bio-logi-cal functions are still unclear. We have studied the role of iris tissue in hyal-uro-nan production in the anterior segment of the eye, and its changes after trauma. After peripheral iridectomy or argon laser treatment, the

Popular Abstract in English Neuroplasticity is the brain´s capacity to respond to inner and outer challenges with functional and structural reorganizations. An aberrant activation of neuroplasticity pathways may contribute to the development of neurological disease. In the case of Parkinson’s disease (PD), the induction of motor complications by L-DOPA pharmacotherapy is generally regarded as an eNeuroplasticity is the brain´s capacity to respond to inner and outer challenges with functional and structural reorganizations. An aberrant activation of neuroplasticity pathways may contribute to the development of neurological disease. In the case of Parkinson’s disease (PD), the induction of motor complications by L-DOPA pharmacotherapy is generally regarded as an example of maladaptive plasti

Popular Abstract in Swedish Den här avhandlingen har behandlingsresultaten av permanent djupelektrod stimulering i hjärnan (Deep Brain Stimulation, DBS) undersökts ur såväl symptomminsknings som patients och närståendes perspektiv. DBS behandling innebär att en elektrod med fyra poler opereras in i hjärnan genom ett litet hål i skallbenet, och den kopplas till pulsgivardosa. Hela systemet är doltThe treatment related effects and personalized goal fulfilment of Deep Brain Stimulation (DBS) have been assessed in studies with different designs. The brain targets included the thalamus for medically intractable tremor in Parkinson's disease (PD) or essential tremor (ET) and the subthalamicus for reducing hypo-, bradykinesia, tremor, rigidity and dystonia in PD. A Swedish multi-center study sh

In this concluding chapter, the editors take a step back, zoom out and reflect upon the significance of theoretical developments presented and what empirical implications this knowledge may have. In addition to discussing the state of this emerging research field of projectification, the chapter also opens up for further research and invites scholars from different fields of research and with diff

The majority of studies on internal brand equity examine its various dimensions and relationships between them. While prior research specifies organizational practices relevant for successful internal branding, the insights about the impact of essential organizational factors on internal brand equity are still limited. This study focuses on organizational resilience that is vital for the existenceThe majority of studies on internal brand equity examine its various dimensions and relationships between them. While prior research specifes organizational practices relevant for successful internal branding, the insights about the impact of essential organizational factors on internal brand equity are still limited. This study focuses on organizational resilience that is vital for the existence

Background: Child mortality differed greatly within rural regions in Europe before and during the mortality transition. Little is known about the role of nutrition in such geographic differences, and about the factors affecting the nutritional status and hence the disease outcomes.Objective: Focusing on nutrition, we analyse the effects of soil type, used as an indicator of the farm-level agricultBackground: Child mortality differed greatly within rural regions in Europe before and during the mortality transition. Little is known about the role of nutrition in such geographic differences, and about the factors affecting the nutritional status and hence the disease outcomes.Objective: Focusing on nutrition, we analyse the effects of soil type, used as an indicator of the farm-level agricult

Summary Background: The aim was to assess sexual risk-taking behaviour in a sample of Swedish youth who were sexually active while travelling abroad and to examine possible associations with sexual risk-taking behaviour during such travel.Methods: From a population-based sample of 2189 Swedes 18e29 years 768 who were sexually active while abroad, were assessed by a questionnaire concerning socio-dSummary Background: The aim was to assess sexual risk-taking behaviour in a sample of Swedish youth who were sexually active while travelling abroad and to examine possible associations with sexual risk-taking behaviour during such travel.Methods: From a population-based sample of 2189 Swedes 18e29 years 768 who were sexually active while abroad, were assessed by a questionnaire concerning socio-d

Risk measures such as Value at Risk are highly dependent on a sample of daily returns. The daily return can be measured in different intervals and this thesis examines how the choice of the daily return interval affects derivative pricing, risk measures, fund performance and products with collateral agreements. It is shown that the VaR measure varies significantly with the choice of daily return i

A signal with harmonic structure is often characterized by its fundamental frequency, or pitch. This single parameter contain vital information of a range of applications such as musical transcription, tuning of stringed instruments, speech processing and more. Some signal sources, for instance a sti vibrating string, exhibit waveforms with slightly deviating harmonic structure. This phenomenon is

Smart city is a phenomenon here to stay, constantly evolving and expanding and is fast becoming a paradigm for the transformation of connected cities. More and more parts of cities are being connected and with it, the risks and issues are on the rise. However, smart city projects often overlook the pervasive cyber security risks and threats that permeates these initiatives. The endeavour of this r

The underwater noise has a significant negative impact on marine animals. The EU has made efforts to keep noise emission within sustainable limits, but only in regards to boats with Automatic Identification System (AIS). The noise of recreational boats, which are the main noise emitter in coastal areas, is overlooked. Thus, there is a need to quantify the noise emitted by recreational boats and, i

The purpose of this study was to investigate social workers’ experience of communicating with children using an interpreter and analysing the challenges. We conducted qualitative interviews with the focus groups of social workers in a city in the southern part of Sweden. They all served at the social services in the municipality. Totally, four focus group interviews were conducted with four partic

The time-frequency (TF) spectral representation of Auditory Brainstem Response (ABR) signal data provides information about their spectral contents. We apply the Spectrogram, Thomson Multitaper and Peak Matched Multiple Window (PM MW) spectral estimation methods to four different number of clicks per average (i.e., 1313, 300, 100 and 50 number of clicks per average) of a simulated signal data. For