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Popular science The carbon balance of the forest ecosystems is determined by the uptake and release of carbon. Forests take up carbon dioxide (CO2) by photosynthesis and release by respiration. One part of the assimilated carbon is respired back to the atmosphere by vegetation. The other part is respired by soil microbes which decompose organic material in soil. The microbial respiration is contro

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Multifunctional proteins, which play a critical role in many biological processes, have typically evolved through the recruitment of different domains that have the required functional diversity. Thus the different activities displayed by these proteins are mediated by spatially distinct domains, consistent with the specific chemical requirements of each activity. Indeed, current evolutionary theo

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Charge regulation is fundamental in most chemical, geochemical, and biochemical systems. Various mineral surfaces and proteins are well-known to change their charge state as a function of the activity of the hydronium ions, that is, the pH. Besides being modulated by the pH, the charge state is sensitive to salt concentration and composition due to screening and ion correlations. Given the importa

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Many pathogenic bacteria utilise sialic acids as an energy source or use them as an external coating to evade immune detection. As such, bacteria that colonise sialylated environments deploy specific transporters to mediate import of scavenged sialic acids. Here, we report a substrate-bound 1.95 Å resolution structure and subsequent characterisation of SiaT, a sialic acid transporter from Proteus