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Jordbruksmodernisering har dramatiskt ökat tillgången till mat på global nivå, men till ett högt pris för miljön. Idag efterlyser många ett ’paradigmskifte’ i jordbruket, även flera stora mainstream-institutioner. Med ett skifte till vad? Under senare år har det synts en ökande tilltro till agroekologi, ett alternativ som syftar till att förstå och bedriva jordbruk som komplexa agroekosystem. FrånAgricultural modernization has massively increased global food supply, but at a high environmental cost. Today many are calling for an agricultural ‘paradigm shift’, including several mainstream institutions. But to what? In recent years, agroecology has gained credence as an alternative approach that seeks to understand and manage farms as complex agroecosystems. From a development perspective, i

Popular Abstract in Swedish En studie av hur glokokortikoider hämmar inflammation Glukokortikosteroider, varav kortison är den mest kända, är hormoner som reglerar många funktioner i kroppen och även används som läkemedel för att dämpa inflammatoriska tillstånd som t.ex. astma och reumatiska sjukdomar. Glukokortikosteroider är mycket potenta läkemedel och används flitigt med mycket goda effekter.The aim of this investigation has been to study mechanisms by which glucocorticoids inhibit inflammatory processes in vitro. Type IV cytosolic 85 kDa phospholipase A2 (cPLA2) is an important modulator of inflammatory responses that is present in macrophages as well as in other cell types. In macrophages, the synthetic glucocorticoid dexamethasone (dex) was found to reduce the expression of cPLA2 a

Popular Abstract in Swedish Patienter med kroniskt obstruktiv lungsjukdom, KOL, har en försämrad lungfunktion och lider av bronkit och andnöd. Dessa symptom beror troligtvis på en ständigt pågående inflammation i lungan som dels leder till ökad slemproduktion och förträngning av luftrören, dels till emfysem dvs. nedbrytning av lungvävnaden vilket försämrar gasutbytet i lungan. Cigarrettrökning är Chronic obstructive pulmonary disease, COPD, is manifested by chronic airflow limitation due to inflammation and tissue destruction in the lungs. COPD is caused primarily by smoking and with increasing cigarette consumption in the world, the prevalence for COPD will most probably increase in the future. The chronic inflammation in the lungs of these patients is thought to drive the pathogenesis fo

Popular Abstract in Swedish Nästa år är det 400 år sedan Galileo Galilei för första gången riktade ett teleskop mot objekt på himlen. Allt sedan dess har teleskopet varit det viktigaste instrumentet för astronomins utveckling och med dess hjälp har vår kunskap om universum revolutionerats. Tack vare utvecklingen av teleskopet under dessa århundraden har allt ljussvagare objekt kunnat studeras, ochThis thesis presents the work on the design of, construction of, and finally observations with, an experimental setup comprising a small telescope equipped with adaptive optics. The facility has been assembled at Lund Observatory, where also observations on the sky have been made. The aim of this project was to gain hands-on knowledge in the development of a real adaptive optics system and eventua

Popular Abstract in Swedish Denna sammanläggningsavhandling i fysisk planering visar hur viktig rättens och juridikens roll är för planeringen och styrning av landskap och miljö, och de fall som studerats och analyserats är den svenska utbyggnaden av 3G-infrastruktur och vindkraften. Utifrån ett rättssociologiskt planeringsperspektiv visar Stefan Larsson (som också disputerat i rättssociologi tidiThis PhD thesis in Spatial Planning argues for the importance of understanding the approaches to knowledge and rationalities embedded in spatially relevant decision-making. It emphasises the significance of seeing law as an empirical object of study for planning and environmental management. The Swedish development of wind power and 3G mobile infrastructures are used as cases to study these issues

The urinary bladder is responsible for storage and expulsion of urine. Proper urination depends on an ability of the bladder to adjust to increasing volume and to contract during micturition. A disturbance of bladder contractility may affect continence. In the present thesis I have used genetic, biochemical and physiological approaches to examine the role of caveolae and mircoRNAs in bladder funct

Photosynthesis is performed by a multitude of organisms, but in P nearly all cases, it is variations on a common theme: absorption of light followed by energy transfer to a reaction center where charge separation takes place, This initial form of chemical energy is stabilized by the biosynthesis of carbohydrates. To produce these energy-rich products, a substrate is needed that feeds in reductive

Purpose: Childhood cancer is rare, and treatment is frequently associated with long-term morbidity. Disparities in survival and long-term side effects encourage the establishment of networks to increase access to complex organ-conservative strategies, such as brachytherapy. We report our experience of an international cooperation model in childhood cancers. Methods and Materials: We examined the o

In the first national human biomonitoring study in the Slovenian population of adults (18–49 years), including men (n = 297) and lactating primiparous women (n = 304), exposure to polycyclic aromatic hydrocarbons (PAHs) was evaluated. Nine urinary metabolites of four parent PAHs were determined. These included 1-hydroxypyrene (1-OHPYR), 2-hydroxynaphthalene (2-OHNAP), 2-hydroxyphenanthrene (2-OHPH

Introduction: Elevated pulmonary vascular resistance (PVR) is observed in both physiological and pathological states. Pulmonary hypertension (PH) is a condition associated with significant morbidity and mortality in neonates and children and curative pharmacotherapy is lacking in most cases. In utero, a high PVR allows for blood to bypass the lungs through the open ductus arteriosus (DA). Vascular

Background: In animal models, early initiation of therapeutic cooling, intra-arrest, or restored circulation has been shown to be neuroprotective shortly after cardiac arrest. We aimed to assess the feasibility and cooling efficacy of transnasal evaporative cooling, initiated as early as possible after hospital arrival in patients randomized to cooling in the TTM2 trial. Methods: This study took t

Pollen-based quantitative vegetation reconstructions using multiple sedimentary basins from the same area, along with their quantified relevant pollen source areas, are a powerful means to study how long-term human impact has affected vegetation and shaped the currently protected heritage landscapes at different spatial scales. Our study presents the outcome of a palynological investigation in Kar

Introduction: High-inflammation subgroups of patients with psychosis demonstrate cognitive deficits and neuroanatomical alterations. Systemic inflammation assessed using IL-6 and C-reactive protein may alter functional connectivity within and between resting-state networks, but the cognitive and clinical implications of these alterations remain unknown. We aim to determine the relationships of ele

Background: Optimisation of dopaminergic therapy may alleviate fluctuation-related pain in Parkinson’s disease (PD). Opicapone (OPC) is a third-generation, once-daily catechol-O-methyltransferase inhibitor shown to be generally well tolerated and efficacious in reducing OFF-time in two pivotal trials in patients with PD and end-of-dose motor fluctuations. The OpiCapone Effect on motor fluctuations