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Background: Basic management for patients who have suffered a cardiac arrest and are admitted to an intensive care unit (ICU) after resuscitation includes setting targets for blood pressure and managing sedation and temperature. However, optimal targets and management are unknown. Methods: The STEPCARE (Sedation, Temperature and Pressure after Cardiac Arrest and Resuscitation) trial is a multicent
Atomic layer deposition (ALD) of HfOx layers has emerged as a promising strategy for interface passivation in chalcopyrite-based thin-film solar cells. However, the nucleation dynamics of (Ag,Cu)(In,Ga)Se2 (ACIGS) absorbers remain insufficiently understood, particularly regarding the interplay between absorber composition and alkali postdeposition treatments (PDTs). Here, we employ in situ ambient
Randomised controlled trial (RCT) protocols contain essential details needed to understand and evaluate the trial's planned aims, design, data collection methods, monitoring, data analysis, and participants' safety. However, key information is often omitted from paediatric RCT protocols, including details on dose adjustments of interventions based on age, body surface area, or weight; developmenta
Hepatitis A virus (HAV) remains a preventable cause of acute viral hepatitis, with an estimated 159 million new infections and 39 000 deaths in 2019. Although improved care and hygiene reduced deaths, global incidence rose by approximately 4%, driven by increased symptomatic cases and population growth. The availability of safe and highly immunogenic vaccines and the absence of chronic carriage ma
Randomised controlled trial (RCT) protocols contain essential details needed to understand and evaluate the trial's planned aims, design, data collection methods, monitoring, data analysis, and participants' safety. However, key information is often omitted from paediatric RCT protocols, including details on dose adjustments of interventions based on age, body surface area, or weight; developmenta
Due to its effects on the atmospheric lifetime of methane, the burdens of tropospheric ozone and growth of secondary organic aerosol, isoprene is central among the biogenic compounds that need to be taken into account for assessment of anthropogenic air pollution-climate change interactions. Lack of process-understanding regarding leaf isoprene production as well as of suitable observations to con
Ghrelin is a 28 a.a. gastric peptide, recently identified as a natural ligand of the growth hormone secretagogue receptor (orphan receptor distinct from the receptor fur growth hormone releasing hormone). In the present study. radioimmunoassay demonstrated ghrelin-like material in the rat oxyntic mucosa with moderate amounts also in antrum and duodenum. Small amounts: were found in the distal inte
Context: Glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) are cleaved by dipeptidyl peptidase-4 (DPP-4); plasma activity of DPP-4 may be increased in obesity. The impact of this increase on incretin hormone secretion and metabolism is not known. Objective: The aim of the study was to assess incretin hormone secretion and degradation in lean and obese nondiabet
The aim of this work was to predict the effect of technological parameters on the physical processes of cheesemaking. To this end we developed and modified techniques with which to measure the physical properties of the curd, such as its permeability and its rheological properties. The effects of different factors, such as pH, temperature, the concentration of casein, the geometry of the curd, app
Two large population-based case-control studies are reviewed. The aim is to determine the effects of HLA, other genetic factors and immune markers (ICA, IAA and GAD65Ab) on the age at onset of insulin-dependent diabetes mellitus (IDDM) in 0-34 year olds. The primary HLA risk gene sequence for IDDM was difficult to identify because of the low recombination frequency within the HLA region. The frequ
Vi som skrivit denna text är en del av forskningsprojektet ILIT. ILIT undersöker hur folkbibliotek fungerar i en tid som präglas av sociala utmaningar. Exempel på utmaningar är segregation, diskriminering, ekonomiska åtstramningar och arbetslöshet. ILIT är en förkortning av Infrastructuring Libraries in Transformation. Projektet har genomförts i Sverige (Malmö), Nederländerna (Rotterdam) och Öster
Objectives: Sjögren's disease (SjD) and systemic lupus erythematosus (SLE) share genetic risk at the DDX6-CXCR5 locus (11q23.3). Identifying and functionally characterising shared SNPs spanning this locus can provide new insights into common genetic mechanisms of autoimmunity. Methods: Transdisease meta-analyses, fine-mapping, and bioinformatic analyses prioritised shared likely functional single
Background and Aims: Colon capsule endoscopy (CCE) provides a non-invasive alternative to traditional colonoscopy. This study evaluated the feasibility, safety, diagnostic yield (DY), and patient satisfaction of the OMOM CC100 CCE system, with special focus on fully remote (n = 30) and partially remote (n = 89) administration across four centres to advance decentralised models. Methods: This prosp
Context. The Near-InfraRed Planet Searcher (NIRPS) is a high-resolution, high-stability near-infrared (NIR) spectrograph equipped with an adaptive optics (AO) system. Installed on the ESO 3.6-m telescope at La Silla Observatory, Chile, it was developed to enable radial velocity (RV) measurements of low-mass exoplanets around M dwarfs and to characterise exoplanet atmospheres in the NIR. Aims. This
Ultra-hot gas giants such as WASP-121b provide unique laboratories for exploring atmospheric chemistry and dynamics under extreme irradiation conditions. Uncovering their chemical composition and atmospheric circulation is critical for tracing planet formation pathways. Here, we present a comprehensive atmospheric characterisation of WASP-121b using high-resolution transit spectroscopy across the
We report the discovery of two warm exoplanets orbiting the cool binary system TOI-2267, composed of the M5 (TOI-2267A) and M6 (TOI-2267B) stars, whose angular separation is 0.384 arcsec, corresponding to a projected distance of only about 8 au at 22 pc from the Solar System. To confirm the planetary nature of these objects, we combined photometry from the Transiting Exoplanet Survey Satellite (TE
Objective: The aim of this study was to achieve an international expert consensus on managing acute type B penetrating aortic ulcers (PAUs) and intramural haematomas (IMHs). Methods: A modified Delphi consensus process was employed to develop recommendations for the management of acute type B PAU and IMH. Surveys were sent to international experts practicing in high volume aortic centres worldwide
Stroke represents one of the most significant global health challenges of the 21st century, with 11.9 million people experiencing stroke annually and a disproportionate burden falling on low- and middle-income countries, where 87% of stroke deaths and 89% of disability occur. Despite stroke being highly preventable—with 84% of the burden attributable to modifiable risk factors—and the availability
