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BACKGROUND: The aim of this study was to explore changes in mobility in terms of ambulation and transfer over 1 year in patients with early-onset Alzheimer's disease (EOAD), and to compare mobility in EOAD with patients with other types of early-onset dementia (EOOD). METHOD: Forty-two patients with EOAD and 30 patients with EOOD were included. All patients were home-dwelling and had mild or moder
Popular Abstract in Swedish Gråstarrskirurgi är en av de vanligaste kirurgiska ingreppen i Sverige med runt 90 000 operationer utförda varje år. En åldrande befolkning med ökade krav på livskvalitet och god synskärpa har lett till en ökad operationsfrekvens och fler kirurger behöver utbildas. Utbildning av nya gråstarrskirurger sker förutom ett fåtal träningstillfällen på grisar, framförallt på paCataract surgery is one of the most common surgical procedures in Sweden and around 90 000 operations are made each year. An aging population with increased demands on quality of life and good visual acuity, has led to an increased rate of surgery and more surgeons needs to be trained. Training of new cataract surgeons is done on scarce wet-lab training but mainly on patients. Training is costly a
In an analytical-method comparison study of clinical samples, the Abbott RealTime CT new formulation assay (m2000 real-time PCR), consisting of a duplex PCR targeting different parts of the cryptic plasmid in Chlamydia trachomatis, was compared both with version 2 of the Roche Cobas TaqMan CT assay, comprising a duplex PCR for a target in the cryptic plasmid and the omp1 gene, and with the Gen-Pro
The recent phenomenon of large-scale acquisition of land for a variety of investment purposes has raised deep concerns over the food security, livelihood and socio-economic development of communities in many regions of the developing world. This study set out to investigate the food security outcomes of land acquisitions in northern Sierra Leone. Using a mixture of quantitative and qualitative res
In this work, a Study of the interfacial properties of redox-active novel ferrocene- and 1,4-naphthoquinone-based compounds containing an alkenyl chain is presented. The miscibility of these corn. pounds with 1-monooleoylglycerol (monoolein, MO), a well-known and much studied substance because of its rich polyinorphism in water, at the air/water interfaces was investigated by using the Langmuir su
Fire accidents in underground transportation systems, e.g., tunnels and underground stations, can cause many fatalities. It is therefore important in fire safety design to give adequate consideration to all aspects related to evacuation. The paper provides a review of two previously reported fire accidents based on a theoretical framework, namely four accepted human behaviour theories. These theor
Using femtosecond transient absorption spectroscopy we have studied light-induced electron injection from the sensitizer RuN3 and its partly deprotonated tetrabutylamonium salt to nano-structured TiO2 film. Previous studies have suggested significant differences in electron injection dynamics for these dyes and some results have indicated that aggregation of the sensitizer may lead to slow injecti
Whereas maintenance of hematopoietic stem cells (HSCs) is a requisite for life, uncontrolled expansion of HSCs might enhance the propensity for leukemic transformation. Accordingly, HSC numbers are tightly regulated. The identification of physical cellular HSC niches has underscored the importance of extrinsic regulators of HSC homeostasis. However, whereas extrinsic positive regulators of HSCs ha
The CNS-restricted versican splice-variant V2 is a large chondroitin sulfate proteoglycan incorporated in the extracellular matrix surrounding myelinated fibers and particularly accumulating at nodes of Ranvier. In vitro, it is a potent inhibitor of axonal growth and therefore considered to participate in the reduction of structural plasticity connected to myelination. To study the role of versica
The impact of the main contaminants usually present in the gas generated during gasification of biomass was studied on a Pt-Rh/MgAl(O) reforming catalyst, which was exposed to solutions of K2SO4, KCl, and ZnCl2 and also to a leached solution of biomass fly ash by aerosol technology on a laboratory scale. The catalyst was exposed to a product gas of a bench-scale downdraft gasifier as well. Untreat
Nation-level Ecological Footprint accounts are currently produced for more than 150 nations, with multiple calculations available for some nations. The data sets that result from these national assessments typically serve as the basis for Footprint calculations at smaller scales, including those for regions, cities, businesses, and individuals. Global Footprint Network's National Footprint Account
Elater ferrugineus is a saproxylic click beetle inhabiting old deciduous trees in Europe. It is threatened throughout its area of distribution due to habitat loss. No efficient monitoring method has been available for this species, but observed attraction of females to (R)-(+)-γ-decalactone, which is a male-produced sex pheromone of its prey, the scarab beetle Osmoderma eremita, has led to the dev
Serviceability of structures has to be verified for a lower load level than the design load used for safety considerations. Representative values of actions used in serviceability load combinations are often defined in a way that the fraction of time spent above a given load level should be limited to a certain value. To determine these load levels more information on the stochastic nature of the
To identify variants for multiple myeloma risk, we conducted a genome-wide association study with validation in additional series totaling 4,692 individuals with multiple myeloma (cases) and 10,990 controls. We identified four risk loci at 3q26.2 (rs10936599, P = 8.70 x 10(-14)), 6p21.33 (rs2285803, PSORS1C2, P = 9.67 x 10(-11)), 17p11.2 (rs4273077, TNFRSF13B, P = 7.67 x 10(-9)) and 22q13.1 (rs877
Huntington's disease (HD) is a fatal neurodegenerative disorder caused by an expanded polyglutamine repeat in the huntingtin protein. Neuropathology in the basal ganglia and in the cerebral cortex has been linked to the motor and cognitive symptoms whereas recent work has suggested that the hypothalamus might be involved in the metabolic dysfunction. Several mouse models of HD that display metabol
Poly(amido amine) (PAMAM) dendrimers have previously been shown, as cationic condensing agents of DNA, to have high potential for nonviral gene delivery. This study addresses two key issues for gene delivery: the interaction of the biomembrane with (i) the condensing agent (the cationic PAMAM dendrimer) and (ii) the corresponding dendrimer/DNA aggregate. Using in situ null ellipsometry and neutron
