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Rates of molecular, phenotypic, and lineage diversification typically scale negatively with time interval of measurement, raising longstanding questions about time-dependency of evolutionary processes. These patterns and their potential meaning have recently re-entered evolutionary discussions. In this Perspective, we revisit the general challenges in interpreting rate–time relationships. Much app
BACKGROUND: A growing body of evidence links microRNAs (miRNAs) to major depressive disorder (MDD). However, the causal nature of these associations remains unclear.OBJECTIVES: This study aimed to investigate the potential causal association between miRNAs and MDD by combining Mendelian Randomization (MR) analyses and experimental validation.METHODS: Single-nucleotide polymorphisms (SNPs) signific
Performance featuring spherical amplification.Bludenzer Tage zeitgemäßer MusikRemise, Bludenz (AT)Ensemble Phace26/09/2024From the program:Romitelli, Fausto (1963-2004, IT) – Professor Bad Trip (for ensemble and electronics) [1998-2000]
Importance Even within individuals who are amyloid positive, clinical symptoms can be impacted by Alzheimer pathology, other pathologic proteins, and cognitive reserve or resilience. Understanding how each of these factors contributes to a patient’s clinical presentation is crucial for prognosis and treatment decisions in the era of disease-modifying therapies. Objective To evaluate tau-clinical m
Building resilient and sustainable energy systems is a critical challenge for disaster-prone regions in the Global South. This study investigates the energy management of a networked microgrid (NMG) system on Lombok Island, Indonesia, a region frequently exposed to natural disasters (NDs) and characterized by vulnerable grid infrastructure. A multi-objective optimization framework is developed to
Sustainability has received increasing attention in recent years, particularly surrounding concerns of poverty in the Global South, the climate emergency, the loss of biodiversity, and the COVID-19 pandemic. Competition and public authorities are more frequently encountering sustainability questions, while states are more generally called upon to foster sustainability by the UN Resolution 70/1. Ag
It remains unclear how transformative innovation policies can be implemented across various regional contexts. Through policy review, interviews and focus group interviews with key actors, this paper investigates industrial regions’ design and implementation of transformative innovation policies in three Nordic countries. We find that the characteristics of the regional innovation system, unique t
Gastrointestinal (GI) interventional endoscopy has evolved into a cornerstone of modern gastroenterology, offering minimally invasive solutions for complex conditions. However, these procedures are not without risk, particularly with respect to post-procedural infections. While rare, such infections can have significant clinical consequences and are increasingly recognized as a public health conce
A biorefinery can operate with various plant materials as feed stock, (in contrast to fossil-based oil refineries). It has been defined by the International Energy Agency, Task 42, as “the sustainable processing of biomass into a spectrum of marketable bio-based products (chemicals, materials) and bioenergy (biofuels, power, heat)”. One of the challenges in operating large-scale facilities is that
Human papillomavirus (HPV) vaccination may eventually eradicate oncogenic vaccine-targeted HPVs but only with a strategy that also protects unvaccinated individuals. We compared the impact of gender-neutral and girls-only vaccination strategies on the indirect and direct protection of unvaccinated and vaccinated young women against HPV16/18 infection using HPV16/18 seropositivity and PCR positivit
Laila Lalami’s novel The Moor’s Account reclaims the erased historical voice of the Moorish slave Estebanico, one of the first Arab Africans on the American continent in the 1500s. While Lalami explicitly positions her novel as a postcolonial revision of Cabeza de Vaca’s colonial report on the fate of Estebanico, this essay argues that a significant part of the novel’s literary resistance to Arab
This article presents a theoretical framework for deriving simple analytical expressions for spurs resulting from second and third order nonlinearities in fractional-N phase locked loops (PLL). Furthermore, a previously proposed linearization technique where several sigma-delta modulators (SDMs) operate in parallel with relative time offsets between them, is further analyzed using the periodic non
PurposeWelfare technology (WT) intends to promote engagement in everyday activities and the well-being of older adults at risk of developing or already having impairments. However, its effectiveness depends on how older adults experience and interact with WT. In this study, we aimed to investigate the relationship between various forms of WT user experience (perceived usability, perceived control,
The satirical underground magazine PUSS, published in twenty four regular numbers in the Swedish language between 1968 and 1973, used provocative images and texts to get its critique and commentary across. This included pornographically coded images depicting nude bodies and genitalia, which in the third issue came in the form of manipulated photographs of nude or semi-nude political leaders. Thes
Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) are rare autoimmune diseases, including granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA) and eosinophil granulomatosis with polyangiitis (EGPA). They are three distinct diseases with overlapping symptoms and signs. The ANCAs involved in AAV are mainly directed against myeloperoxidase (MPO) and proteinase
Peritoneal dialysis is a widely used, cost-effective and accessible renal replacement therapy. Theprimary aim of this thesis is to study and measure the mechanisms that govern fluid and electrolytetransport in peritoneal dialysis by combining theoretical models with experiments on rats and analysisof clinical datasets. Despite the apparent simplicity of the treatment, the physiological mechanisms
Ferroelectricity in Hf0.5Zr0.5O2 (HZO) originates from a polymorphic landscape where the metastable orthorhombic phase competes with monoclinic and tetragonal forms, making functional properties highly sensitive to structural instability. Recent strategies have exploited ionic-vacancy mechanisms, either through redox interactions with the environment or by employing ferroionic heterostructures, to
