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The European Myeloma Network has organized two workshops on fluorescence in situ hybridization in multiple myeloma. The first aimed to identify specific indications and consensus technical approaches of current practice. A second workshop followed a quality control exercise in which 21 laboratories analyzed diagnostic cases of purified plasma cells for recurrent abnormalities. The summary report w
OBJECTIVE - The purpose of this study was to estimate the risks of nontraumatic lower-extremity amputations (LEAS) in patients With type 1 diabetes. RESEARCH DESIGN AND METHODS - We identified 31,354 patients with type 1 diabetes (15,001 women and 16,353 men) in the Swedish Inpatient Register between 1975 and 2004. The incidence of nontraumatic LEAs was followed up until 31 December 2004 by cross-
Natural enemies such as predatory arthropods and parasitoids have the potential to suppress pest species and provide the ecosystem service biological control. When predicting the potential of biological control in agriculture it is important to give evidence on how agricultural management influence the abundance and functions of the natural enemies. In this study we examined whether managements pr
Two recent papers (Foulsham, Barton, Kingstone, Dewhurst, & Underwood, 2009; Mannan, Kennard, & Husain, 2009) report that neuropsychological patients with a profound object recognition problem (visual agnosic subjects) show differences from healthy observers in the way their eye movements are controlled when looking at images. The interpretation of these papers is that eye movements can be
The Greenland ice core from NorthGRIP (NGRIP) contains a proxy climate record across the Pleistocene-Holocene boundary of unprecedented clarity and resolution. Analysis of an array of physical and chemical parameters within the ice enables the base of the Holocene, as reflected in the first signs of climatic warming at the end of the Younger Dryas/Greenland Stadial 1 cold phase, to be located with
Glycerol and urea are examples of small, water-soluble molecules with low vapor pressure that can protect lipid membranes upon dehydration. Both are a part of the Natural Moisturizing Factor in human skin, and are also present in other organisms, where they prevent drying due to osmotic stress. This study was conducted in order to understand the mechanism of such protection. We have selected two t
Legislation in Sweden and the European Union concerning the use of sewage sludge in agriculture is under revision and future concentration limits for pathogens in treated sludge are likely to be expected. The aim of this study was to evaluate the hygienization of Salmonella, Escherichia coli, Enterococcus and Clostridium perfringens through continuous anaerobic digestion at 35, 55 or 60 ºC as well
Negative pressure wound therapy (NPWT) has become widely adopted over the last 15 years and over 1000 peer reviewed publications are available describing its use. Despite this, there remains uncertainty regarding several aspects of usage. In order to respond to this gap a global expert panel was convened to develop evidence-based recommendations describing the use of NPWT. In this paper the result
The rate coefficients for the chemical reactions (species loss rates, quenching excluded) of the refrigerants CH2F2 (HFC-32), CHClF2 (HFC-22) and CH2FCF3 (HFC-134a), and the solvent CH3CCl3 with O(D-1) are determined relative to CH4 + O(D-1) at 298 K. The resulting rates k(CH2F2 + O(D-1)) = (4.78 +/- 1.03) x 10 (11) cm(3) molecule (1) s (1), k(CHClF2 + O(D-1)) = (8.69 +/- 1.72) x 10 (11) cm(3) mol
Modern power plants are all strongly dependent on reliable and accurate sensor readings for monitoring and control, thus making sensors an important part of any plant. Failing sensors can force a plant or component into non-optimal operation, cause complete shut-down of operation or in the worst case result in damage to components. Given their importance, sensors need regular calibration and maint
A common observation in recordings of neuronal activity from the cerebral cortex is that populations of neurons show patterns of synchronized oscillatory activity. However, it has been suggested that neuronal synchronization can, in certain pathological conditions, become excessive and possibly have a pathogenic role. In particular, aberrant oscillatory activation patterns have been implicated in
Subject-verb agreement in number (3sg - 3pl) in spoken French is a heterogeneous morpho-syntactic domain where number is expressed in some groups of verbs and in some phonological contexts only. The acquisition of this agreement is a long and gradual process (Prévost, 2009). Both children learning French as their first language (L1) and older second language (L2) learners overuse the dominant patt
In children’s literature nonhuman primates are often represented either as ferocious beasts or as curios and charmful vicarious children. In this article I demonstrate how these different constructions interestingly coexist in the popular story ‘‘The monkey that would not kill’’, written by the Scottish evangelist and professor of the natural sciences Henry Drummond in 1891. My study anchors the f
In this paper, we formulate the multi-pitch estimation problem and propose a number of methods to estimate the set of fundamental frequencies. The proposed methods, based on the nonlinear least-squares (NLS), Multiple Signal Classification (MUSIC) and the Capon principles, estimate the multiple fundamental frequencies via a number of one-dimensional searches. We also propose an iterative method ba
Handlingsutrymmet för kyrkans sociala engagemang har sett olika ut i olika tider, för att de senare decennierna öka i takt med att legala restriktioner minskat eller försvunnit. Relationen till staten har varit en styrande faktor för detta. I en omvärld alltmer präglad av marknadsvillkor och välfärdspluralism ställs nya krav. Ett sådant är att församlingar tydligare behöver artikulera vad de vill
PURPOSE. To demonstrate noninvasive imaging of human foveal capillary networks with a high-resolution, wide-field, dual-conjugate adaptive optics (DCAO) imaging instrument. METHODS. The foveal capillary networks of five healthy subjects with no previous history of ocular or neurologic disease or surgery were imaged with a novel high-resolution, wide-field DCAO instrument. The foveal avascular zone
Protection against mucosally transmitted infections probably requires immunity at the site of pathogen entry(1), yet there are no mucosal adjuvant formulations licensed for human use. Polyethyleneimine (PEI) represents a family of organic polycations used as nucleic acid transfection reagents in vitro and DNA vaccine delivery vehicles in vivo(2,3). Here we show that diverse PEI forms have potent m
