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Background and objectives: Treatment-resistant schizophrenia (TRS) is a severe subtype of schizophrenia. While negative and disorganised symptoms have been associated with cognitive dysfunction, the underlying neurobiological mechanisms remain unclear. Plasma neurofilament light chain protein (NfL), a biomarker of neuroaxonal damage, has shown promising associations in TRS. This study investigates
Current research indicates that Virtual Reality (VR) can serve as an effective tool for evaluating and training postural control responses and its processing, to distorted sensory input. The aim was to evaluate posturographic spectral responses and adaptation to repeated visual VR-stimulation in young and older adults with wavelet analysis. Twenty-eight young (mean 25.3 years) and 25 older (mean 7
Background: Adherence to exercise interventions is often suboptimal, despite numerous studies documenting barriers and facilitators. Usability may be a critical yet underexplored determinant of adherence. This study aimed to develop and assess the psychometric properties of the Intervention Usability Scale for Exercise (IUSE). Methods: Item generation and content validation involved cognitive inte
BACKGROUND: There are limited data guiding the optimal inflation time for coronary drug-coated balloons. The aim of this study was to assess the clinical efficacy of an inflation time of ≥30 seconds compared with <30 seconds.METHODS: We conducted an observational nationwide analysis using the SCAAR (Swedish Coronary Angiography and Angioplasty Registry) to identify all patients undergoing percutan
BACKGROUND: Finding new ways of treating bacterial infections is essential. The NlpD protein, which inhibits RNA Polymerase II (Pol II), has shown therapeutic efficacy against urinary tract infection. This study investigated the mechanism of Pol II inhibition and protection by NlpD and its LytM peptide.METHODS: Recombinant NlpD and LytM were screened for interactions with constituents of the RNA P
INTRODUCTION: We evaluated associations between phosphorylated au 217 (p-tau217), p-tau181, p-tau231, and vascular risk factors with cognitive outcomes across the Alzheimer's disease (AD) continuum. METHODS: Baseline plasma p-tau concentrations and vascular risk factors were assessed in 277 Consortium for the Early Identification of Alzheimer's Disease–Quebec (CIMA-Q) participants. Associations be
We provide the first comprehensive analysis of the origin of two enigmatic Satyrinae genera of uncertain affinities. Calisto Hübner, the only Satyrinae genus from the West Indies and endemic to these islands, has resisted numerous attempts at phylogenetic placement, regardless of the data type or methods used. Llorenteana Viloria & Luis-Martínez, a monotypic genus from northwestern Mexico, has
BACKGROUND AND PURPOSE: The experience of having a child monitored for vital signs in relation to surgery for congenital heart disease can be highly stressful for parents. The opportunity to be involved in their child's care is central to parents' well-being and to their overall experience of the care provided. The purpose of this study was to explore how parents of children with congenital heart
PURPOSE: To describe healthcare professionals lived experiences of being nudged to use transcutaneous electrical nerve stimulation (TENS) in post-anesthesia care.DESIGN: Descriptive phenomenological study.METHODS: A 12-week transparent, passive and asynchronous nudge strategy was implemented in a 15-bed surgical recovery ward where healthcare professionals were exposed to rotating posters to encou
BACKGROUND: Previous cross-sectional studies report an association between psychological distress and severity of pain and symptoms in patients with longstanding non-arthritic hip and groin pain (LHGP). However, there is a lack of longitudinal studies exploring changes in psychological distress over time, and whether these changes relate to changes in pain and symptoms in LGHP patients. This study
Fiscal and monetary policy in the euro area stand at a crossroads. The rules- based framework established in the 1990s—the Maastricht Treaty and the Sta- bility and Growth Pact—has failed to prevent the steady accumulation of public debt, which now stands closer to 90% of GDP than to the Treaty’s 60% ceiling. Successive crises have pushed member states beyond the fiscal limits, while the European
Achieving a successful transition depends on how structural conditions, strategic choices, and performance outcomes interact within firms. This study examines the causal relationships among sustainability drivers in the construction sector, focusing on Turkey and Sweden as contrasting institutional contexts. Using a Most Different System Design, the analysis applies the fuzzy DEMATEL method to eva
Artificial neural networks (ANNs) are employed to predict the energy levels of quantum systems, including the hydrogen atom, the harmonic oscillator, and the particle in a box, using various activation functions. The results demonstrate that the choice of activation function significantly influences prediction accuracy. This data-driven framework provides a powerful alternative to explicitly solvi
In a high-energy physics data analysis, the term “fake” backgrounds refers to events that would formally not satisfy the (signal) process selection criteria, but are accepted nonetheless due to mis-reconstructed particles. This can occur, e.g., when leptons from secondary decays are incorrectly identified as originating from the hard-scatter interaction point (known as non-prompt leptons), or when
How do political blocs form, consolidate, and dissolve? And can we trace these dynamics through the language of parliamentary debate? We address these questions by analyzing speeches in the Swedish Riksdag, using supervised machine learning to examine changes in rhetorical alignment among parties. Adapting classification methods developed for two-party systems to a multiparty context, we assess rh
In this work, we investigate carrier recombination dynamics and defect-related emission behavior in high-indium content InGaN platelets containing a single quantum well (QW) and a transition layer (TL) using temperature-dependent monochromatic cathodoluminescence (CL) imaging and time-resolved CL (TRCL). At low temperature, monochromatic CL imaging reveals expanded apparent emitting area of both l
