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Parkinson’s disease (PD) is a progressive neurodegenerative disease that comprises a range of motor and nonmotor symptoms. Glial cell line-derived neurotrophic factor (GDNF) promotes the survival of dopamine neurons in vitro and in vivo, and intracranial delivery of GDNF has been tested in six clinical trials for treating PD. However, clinical trials with ectopic GDNF have yielded variable results
Structured triacylglycerols (STAG) with desired properties can be synthesized by transesterification using immobilized lipases. Herein, the effect of immobilization conditions and support material on the immobilization yield, specific activity and regioselectivity of lipases from Rhizomucor miehei (RML) and Rhizopus oryzae (ROL) in the production of STAG, are evaluated. Four different support mate
The pancreatic islet is a highly structured micro-organ that produces insulin in response to rising blood glucose. Here we develop a label-free and automatic imaging approach to visualize the islets in situ in diabetic rodents by the synchrotron radiation X-ray phase-contrast microtomography (SRμCT) at the ID17 station of the European Synchrotron Radiation Facility. The large-size images (3.2 mm ×
In an explorative manner this article uses a data driven digital history set-up to focus on broad cultural heritage issues in Sweden during the second half of the 20th century. By distant reading and topic modeling a dataset of 3100 Swedish Government Official Reports (SOU) between 1945–89, the article gives a new perspective of how the Swedish state examined and discussed national cultural herita
EU FireStat project brings together the knowledge and experience of nine different international fire safety institutions. The project maps the existing fire data collected across Member States and proposed meaningful data sets to allow decisions on fire safety at Member State and at EU level. This project was carried out by a consortium composed of nine international fire safety institutions: Efe
This doctoral dissertation in public law maps and analyses protection from domestic violence for family migrants in relation to family migrants' right of stay in Sweden from 2000-2022.The thesis covers legal protection from domestic violence in three cases: a denied right of stay before immigration takes place if it can be assumed that the person applying for a residence permit based on family tie
Ovarian cancers (OC) occupied 7th place in incidence and 4th place in mortality rate among all malignancies. The OC deadliness results from two reasons: a) the absence of specific clinical manifestations followed by diagnosis at later stages with metastatic lesions, and b) a reliable verification problem. The study aimed to improve the complex differential diagnostic morphological criteria for mal
Nowadays, distance learning is a necessary measure under pandemic circumstances. Therefore, it is important to find mechanisms to improve its effectiveness, especially in the case of practical classes. Two equal groups of medical students (term 6) studied with different teaching approaches: control with classical one (material discussion followed by the practical skills implementation) and experim
Bygg- och fastighetssektorn står inför en stor förändringsprocess för att kunna minska sin miljö- och klimatpåverkan. Ur ett europeiskt perspektiv står byggsektorn idag för hälften av alla råvaror som utvinns, hälften av den totala energianvändningen, en tredjedel av all vattenanvändning och en tredjedel av allt avfall som genereras. Genom att skapa en mer cirkulär byggbransch minskar klimatutsläp
Dictyostelid cellular slime molds (dictyostelids) are ubiquitous microorganisms found in the uppermost layers of most soils. Reports on the species diversity of dictyostelids in Southeast Asia, particularly Thailand, are few in number. A survey for dictyostelids performed in northern Thailand in 2008 recovered 15 distinctive forms, including several common species and a number of forms morphologic
Samples for isolation of dictyostelid cellular slime molds were obtained from 20 collecting sites at 18 localities in south central and southeastern Madagascar during May 2009. At least thirty species of dictyostelids representing seven genera were recovered from 52 samples of soil/humus. This total included 17 species described as new to science, 13 species already known from various localities t
Mountains are arguably Earth's most striking features. They play a major role in determining global and regional climates, are the source of most rivers, act as cradles, barriers and bridges for species, and are crucial for the survival and sustainability of many human societies. The complexity of mountains is tightly associated with high biodiversity, but the processes underlying this association
D. M. Wilkinson (2010, Journal of Biogeography, 37, 393-397) suggested that anthropogenic dispersal is an understudied and potentially important factor in terrestrial protist biogeography. We investigated human footwear as a potential vector of dictyostelids, a diverse group of amoebae that includes both geographically restricted and cosmopolitan species. Eighteen pairs of boots were examined and
The dictyostelid social amoebae (Dictyostelia) occur in terrestrial habitats worldwide. It has been observed previously that their diversity decreases with increasing latitude and altitude. Here we look at dictyostelid diversity in the high latitude habitats of Northern Sweden. Dictyostelids were recovered from soil samples using traditional plating methods and then identified using morphological
