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Collaborative innovation has emerged as a way to share risks and costs associated with the innovation process. However, identifying and establishing contact with suitable collaboration partners proves challenging. To overcome this barrier, knowledge brokers, such as innovation agencies or universities, can step in to bridge contacts between innovative firms. This paper provides a long-term case st
Donald Trump kan avskeda ämbetsmän och pressa centralbanken. Men finansmarknaden kan han inte avsätta. Tullreträtten i fjol visar varför marknaden kan fungera som en vakthund för demokratin, skriver Lars Jonung.
Background The objective of this study was to provide a multimodal biomarker characterization of amnestic objective subtle cognitive decline (obj-SCD) in aging and preclinical Alzheimer’s disease (AD). Methods Prospective observational study; data from the Alzheimer’s and Families+ (ALFAs+) cohort, including cognitively unimpaired (CU) individuals with available baseline CSF biomarkers (normal or
Background: Stroke is the second leading cause of death and the third leading cause of disability worldwide, with global economic costs exceeding US $890 billion annually and a projected 50% rise in deaths between 2020 and 2050. So far, stroke has been addressed within the World Health Organization (WHO) Global Noncommunicable Disease (NCD) Action Plan 2023–2030 and the Intersectoral Global Action
Background Obstructive sleep apnea (OSA) frequently coexists with coronary artery disease (CAD) and may contribute to heart failure with preserved ejection fraction (HFpEF). Whether HFpEF-like features are reversible with continuous positive airway pressure (CPAP) therapy remains uncertain. Methods A total of 177 revascularized CAD patients with nonsleepy OSA (Epworth Sleepiness Scale score <10; a
CD8 + T-cell presence and distribution in oropharyngeal cancer (OPC) reflects specific immune phenotypes and are linked to prognosis. Image processing methods such as convolutional neural networks (CNN) may enhance treatment decisions. From standard computed tomography (CT) images, this study evaluates radiomics in combination with machine learning models and CNN for prediction of spatially resolv
Elevated troponin I (TnI) has been reported in patients with chronic obstructive pulmonary disease (COPD) without cardiovascular disease (CVD), suggesting non-ischaemic mechanisms. We assessed this association in a population-based cohort of 22 526 individuals without known CVD or significant coronary artery calcification. TnI showed no association with COPD (adjusted OR 0.87, 95% CI 0.60 to 1.26;
The development of wide bandgap perovskite solar cells (WBG PSCs) holds significant promise for advancing tandem solar cells. However, the intrinsic rapid crystallization kinetics severely impedes the vertical-oriented growth and homogeneous film formation of perovskite crystals, leading to high defect density and compromised device performance. This work proposes an innovative molecular interfaci
Localizing users and mapping the environment using radio signals is a key task in emerging applications such as reliable low-latency communications, location-aware security, and safety-critical navigation. Recently introduced multipath-based simultaneous localization and mapping (SLAM) methods can jointly localize a mobile agent and map reflective surfaces in radio frequency (RF) environments. Mos
This study extends conventional life cycle assessment (LCA), which typically assumes an incident-free service life, to explicitly incorporate fire events and fire protection systems, enabling systematic quantification of their environmental consequences and mitigation effects in timber buildings. A proof-of-concept application was conducted for a timber-based residential compartment under four rep
This study presents a comprehensive 25-year chronology of air pollution and climatic variable disparity across seven SAARC nations—Afghanistan, Bangladesh, Bhutan, India, Nepal, Pakistan, and Sri Lanka—emphasizing the region’s developing burdens of fine PM2.5 and SO2 from 2000 to 2024. MODIS and MERRA-2 data are used for a regional-scale analysis of seasonal, annual, and inter-annual variations in
Aims: To investigate differences between respondents’ self-reported registration with public and private primary healthcare (PHC) providers according to self-reported illness burden in the early phase of the free choice reform. Methods: The Public Health Survey undertaken in Scania, southernmost Sweden, in 2012 was a population-based study of a stratified random sample of 18–80-year olds that elic
Background: – When decision makers use evidence from a randomized trial to inform population-level decisions, the target population they envision rarely aligns with the population of individuals who enrolled in the trial. Here, we extend inferences from the VALIDATE-SWEDEHEART randomized trial (hereafter, the index trial), which compared the effects of bivalirudin and heparin during percutaneous c
Tetralogy of Fallot (TOF) patients are at risk for long-term adverse events. Electrocardiogram (ECG) abnormalities may reflect ventricular maladaptation and predict complications. We investigated whether ECG changes correlated with cardiac magnetic resonance imaging (CMR) measures of right ventricular (RV) function and their prevalence in less mature myocardium (prematurity or early repair). This
Here, density functional theory calculations are used to evaluate Ti4C3 and Ti4N3 MXenes as sodium ion-battery (SIB) anodes. Both MXenes offer multiple energetically favorable Na adsorption sites with strong binding, supporting uniform Na accommodation and mitigating Na clustering. The Na adsorption increases the electronic density near the Fermi level that enhances metallic conductivity for effic
Is high fertility related to shorter lifespan? Evolutionary theories predict negative physiological effects of fertility on women’s later-life survival. However, kin and especially one’s own children may contribute positively to women’s survival in old age. Family members may transfer resources and provide caretaking assistance as women age and be a source of social support that contributes to hea
Since 2016, the Alzheimer's Association and the Fondation Alzheimer have hosted Global Alzheimer's Leadership Series (GoALS) global think tanks, with world-leading experts for innovative discussions to advance Alzheimer's disease (AD) research and care. The second GoALS think tank, held in June 2024 in Paris, focused on the relationship between biological changes and clinical manifestations of AD
