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Aims Surgeon and patient reluctance to participate are potential significant barriers to conducting placebo-controlled trials of orthopaedic surgery. Understanding the preferences of orthopaedic surgeons and patients regarding the design of randomized placebo-controlled trials (RCT-Ps) of knee procedures can help to identify what RCT-P features will lead to the greatest participation. This informa

Objectives To determine development of new and worsening meniscal damage over 5 years after acute anterior cruciate ligament (ACL) injury comparing rehabilitation plus early ACL reconstruction (’early-ACLR’) versus rehabilitation with optional delayed ACL reconstruction (’optional-delayed-ACLR’). Methods We used knee MRIs from the only randomised controlled trial in the field including 121 young a

Knee osteoarthritis affects 40% of people during their lifetime, significantly impacting societies worldwide. Its molecular pathogenesis remains poorly understood and variable clinical phenotypes suggest it may be more than one disease. We established Synovial fluid To detect Endotypes by Unbiased Proteomics in OA (STEpUP OA) to search for molecular endotypes in knee OA synovial fluid, and to reve

PurposeEconomic claims after surgery may be regarded as an alternative surrogate outcome for long-term deprived quality of life. This study reports economic claims of chronic pain following inguinal hernia repair.MethodsConsecutive data on economic claims following inguinal hernia repair was collected from the nationwide Danish Patient Compensation Association. Patients’ claims were stratified int

This thesis investigates the global landscape of indicators used to measure climate resilience within Water, Sanitation, and Hygiene (WASH) services through a systematic mapping and gap analysis. As climate change increasingly threatens water security and public health, there is an urgent need for theoretically grounded monitoring frameworks to evaluate systemic resilience across diverse contexts.

The objective of the research is to investigate how Frontex, the European Border and Coast Guard Agency, uses its Guidebook for Children in Return to reconcile the violence of deportation and Frontex human rights violations with a humanitarian self-image. Through an intersectional lens, the analysis focuses on how race and gender are represented and how this representation contributes to sustainin

Purpose: The persistent congestion and prolonged waiting times of trucks at maritime container terminals undermine port performance and supply chain efficiency. Ensuring smooth truck flows is essential for ports to fulfill their economic and social roles in global trade, creating significant pressure on operators to deliver reliable service. To support these efforts, it is crucial to identify

The aim of the study was to explore the meaning attributed by specialist ambulance nurses to the process of establishing and maintaining a caring relationship in the prehospital context.BackgroundPrevious studies suggest that some patients may feel overlooked or not taken seriously in encounters with the ambulance service. Even brief caring relationships in prehospital care can support well-being,

Multiple myeloma (MM) and related malignancies develop from an asymptomatic precursor condition, monoclonal gammopathy of undetermined significance (MGUS), detectable via blood testing. The benefits and harms of population-based MGUS screening remain uncertain. We conducted a nationwide screening study for monoclonal gammopathies and a randomized trial of follow-up strategies in Iceland (Iceland S

Abstract published in relation to the Nordic COnference on Forensic Medicine.

Immune tolerance induction (ITI) to eradicate an immune response against factor VIII (FVIII) has been used in hemophilia A (HA) with various success rates, costs, and treatment burden. The present study aimed to identify markers predictive of ITI success. Data were accrued from 237 patients with severe HA (FVIII level < 1%), history of persistent FVIII inhibitors ≥ 1 BU/mL and having performed ITI

Factors limiting fat cell expandability remain scarcely explored, and comprehensive functional comparisons of adipose depots in humans are limited. In the present study, we collected visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) paired-samples from 22 patients with obesity undergoing elective Roux-en-Y gastric bypass surgery. Whole tissue samples were used to determine adipoc

BACKGROUND: Recent advancements in single-cell transcriptomic analyses have greatly expanded our understanding of cellular diversity in adipose tissue, indicating transcriptionally distinct subpopulations of adipocytes. Here we sought to rigorously test such heterogeneity at the protein level.METHODS: A data-driven imaging platform was tailored to assess cellular protein levels based on immunofluo