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Objectives: – To quantify the risk of incident psychiatric morbidity after community-acquired sepsis and assess whether new chronic diseases mediate the association. Design: – Nationwide, population-based matched register cohort; hazards estimated with weighted Cox regression. Setting: – Sweden, linking the National Quality Sepsis Registry, National Patient Register, Prescribed Drug Register, and
Quantification using the Centiloid (CL) scale has become a valuable information to consider when interpreting amyloid-PET images and is now implemented in several software packages. This work aims to assess the comparability of CL from [18F]flutemetamol scans derived using several research and commercial quantification pipelines. Methods: This analysis relies on three datasets: a test-retest cohor
This study investigates the impact of a 10-week Arts on Prescription (AoP) program in Denmark designed for young adults aged 18–30 who were disengaged from education and unemployed. Eighteen participants took part in four semi-structured focus group interviews, and four completed a survey; most reported experiences of anxiety, depression, and stress, with some describing chronic pain, ADHD, or aut
Background: Fine-needle aspiration biopsy (FNAB) is the preferred first-line diagnostic tool for evaluating lymphadenopathy due to its minimally invasive nature and cost-effectiveness. However, cytopathological interpretation of lymph node FNAB remains challenging because of the wide morphological spectrum of lymphoid lesions. The World Health Organization (WHO) Reporting System for Lymph Nodes, S
Background Drug use disorder (DUD) clusters in families due partly to shared environment, including sibling influences. Low academic achievement (AA) in adolescence increases DUD risk. This study examined whether low AA in an older sibling causally increases DUD risk in younger siblings. Methods We studied all Swedish full sibling pairs (n = 309,666) born 1972–1985 and ≤ 5 years apart. Older sibli
Both high-mountain rivers and wet-based mountain glaciers are considered effective erosion agents. They acted alternatively or simultaneously during the late Quaternary in the Tatra Mountains (West Carpathians) thus producing a vast amount of clastic material that was subject to deposition, reworking and transportation downstream. A small fraction of that amount of the material is still preserved
Seagrass meadows are recognized for their coastal protection services in terms of reducing the wave runup level and limiting coastal erosion. This study aims to quantify these services for a dense seagrass meadow located in a non-tidal, fetch-limited sea. A year-long field campaign was conducted to collect data on wave statistics along the cross-shore direction of the seagrass meadow, bathymetry,
BACKGROUND: Alterations in ribosomal DNA copy number (rDNA-CN) and global DNA methylation have been associated with genomic instability and various diseases. However, their relevance in myocardial infarction (MI) has not been fully investigated.METHODS: We measured rDNA-CN and global DNA methylation in blood samples from MI patients ( n = 100) and healthy controls ( n = 109) using Droplet Digit
Human calcitonin (hCT) is a peptide hormone with therapeutic potential for bone-related disorders, yet its clinical application is hindered by a strong propensity to form amyloid fibrils. Strategies that effectively suppress hCT aggregation are therefore essential for enabling its reintroduction into pharmaceutical development. In our previous work, heme emerged as a potent inhibitor of hCT fibril
We present the structural and functional characterization of a single-stranded DNA-binding protein (SSB-M5) identified from a hot spring metagenome in Vatnajökull National Park, Iceland. This small protein (136 aa; 15,695 Da) shares 100% amino acid sequence identity with two previously uncharacterized SSBs from hyperthermophilic Fervidobacterium species. Functional complementation assay demonstrat
Interactions between amyloidogenic proteins are emerging as critical drivers of neurodegenerative diseases. Among others, in Alzheimer’s disease (AD) and severe forms of chronic traumatic encephalopathy (CTE), codeposition of tau and amyloid-β (Aβ) leads to worsening of clinical outcomes and disease progression. Despite the importance of such heterotypic interactions, the underlying molecular mech
BACKGROUND: Long COVID has emerged as a global health challenge, with increasing evidence of cardiovascular sequelae. Most previous studies have focused on hospitalised cohorts, whereas cardiovascular risk in community-managed long COVID cases remains less explored. We aimed to investigate the incidence of major cardiovascular events in individuals with long COVID compared to those without long CO
Postural orthostatic tachycardia syndrome (POTS) is associated with multiple autonomic symptoms, including gastrointestinal (GI) complaints, and has been linked to insulin resistance. We aimed to explore HbA1c, circulating metabolic hormones (insulin, C-peptide, GIP, GLP-1, glucagon, leptin, and peptide YY) and cortisol, and their associations with hemodynamic parameters and GI symptoms in POTS. T
In this paper I summarise the findings presented in my recent PhD thesis in which I include some 80+ linguistic theories from Plato to Usage-based linguistics in order to enquire into the potential of linguistic theories in the study of aspect and tense in Ancient and particularly New Testament Greek. I discuss the challenge of working with several linguistic theories at the same time, the formati
Forests play a vital role in maintaining the global carbon balance. However, globally, forest ecosystems are increasingly threatened by climate change and deforestation in recent years. Monitoring forests, specifically forest biomass is essential for tracking changes in carbon stocks and the global carbon cycle. However, developing countries lack the capacity to actively monitor forest carbon stoc
Species distribution models (SDM) have been used to estimate potential geographic distributions of hundreds of species and plant communities. Nonetheless, very few studies have been conducted which attempted to model the distributions of mangrove species in future under climate change scenarios and under different sea surface salinity at a local level. The present study used a machine learning bas
