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Cancer immunotherapy targeting the CD40 receptor on antigen presenting cells (APCs) is a promising treatment strategy that promotes priming of tumor-specific T cells and can revert a suppressive tumor microenvironment. CD40 signaling in dendritic cells (DCs) has been shown to promote maturation, enhance expression of MHC, costimulatory molecules and chemokine receptors, and induce IL-12 secretion,
Single-cell RNA sequencing (scRNA-seq) combined with immune receptor analysis is a significant breakthrough in immunology, enabling detect of gene expression and T-cell receptor (TCR) at the single-cell level in the same sample. However, current "gold standard" methods like 10x Genomics 5' V(D)J rely entirely on fresh samples, which severely limits their application in clinical studi
Denna studie ämnar identifiera olika aspekter av hur svenska värnpliktiga internaliseras genom den militära socialiseringsprocessen under den militära grundutbildningen. Särskilt analyseras hur militära normer, disciplin, hierarki samt roll- och identitetsskapande utvecklas och upprätthålls genom militära rutiner och anpassning till kollektivet inom institutionens ramar. Studien utgår från en kv
Small poikilothermic animals like insects rely on environmental sensing for survival. The ability to detect humidity through specialized sensory neurons is particularly critical, allowing them to maintain water balance across diverse environments. While recent studies have identified key receptors associated with humidity sensing, our understanding of the underlying molecular architecture of these
Background: Patients with relapsing–remitting multiple sclerosis (RRMS) experience fatigue and impaired information processing speed (IPS) frequently, even in the absence of clinical or radiological disease activity. Previous studies investigating associations between fatigue, IPS, neurofilament light chain (NfL) and glial fibrillary acidic protein (GFAP) have reported conflicting results. Objecti
In today’s world of increasing spatial inequalities, geopolitical tensions and global shifts in value chains, having a solid grasp of the spatial and multi-scalar dynamics that condition transition dynamics is of ever more importance. Initial theories of sustainability transitions have been criticised for being insufficiently equipped to assess the benefits, conflicts and unevenness that are const
Altermagnetism represents a recently established class of collinear magnetism that combines zero net magnetization with momentum-dependent spin polarization, enabled by symmetry constraints rather than spin-orbit coupling. This distinctive behavior gives rise to sizable spin splitting even in materials composed of light, earth-abundant elements, offering promising prospects for next-generation spi
Water diffusion gives rise to micron-scale sensitivity of diffusion MRI (dMRI) to cellular-level tissue structure. Precision medicine and quantitative imaging depend on uncovering the information content of dMRI and establishing its parsimonious hardware-independent fingerprint. Based on the rotational SO(3) symmetry, we study the geometry of the dMRI signal and the topology of its acquisition, id
The research study examines how employees in private and public sector organisations utilize AI-powered tools in organisational decision-making, focusing on the perceived benefits and challenges of their use. It further examines how such tools can enhance decision quality. A qualitative research design was employed, involving interviews with purposively selected employees from organisations in Swe
Ultraviolet radiation exposure and a fair pigmentation phenotype are well-established risk factors for primary cutaneous melanoma. However, the prognostic relevance of these risk factors is largely unexplored in metastatic disease. The aim of this study was to examine whether phenotypic characteristics and sun exposure patterns affect the prognosis of metastatic melanoma with immunotherapy availab
Escherichia coli O157:H7 is a non-invasive Shiga toxin (Stx)-producing pathogen that causes gastroenteritis and hemolytic uremic syndrome characterized by acute kidney injury. Stx binding to cells induces release of extracellular vesicles (EVs) containing the toxin. This study aimed to demonstrate the lethal effects of toxin-positive vesicles, and the importance of the Stx receptor, globotriaosylc
The songbird brain region called Cluster N has been implicated as important for low-light vision and/or the perception of Earth’s magnetic field for migratory orientation. This region of the visual Wulst is active in migratory songbirds under dim light conditions and an intact Cluster N is necessary for magnetic compass orientation in a nocturnally migrating songbird species. Given that magnetic f
This document has been developed as a comprehensive roadmap to the organization of paediatric and congenital echocardiography laboratories, as well as the governance of echocardiography services and training across Europe. The following key topics will be reviewed and discussed: (i) the setup and organization of paediatric and congenital echocardiography laboratories; (ii) staffing requirements fo
The article describes how a series of adaptions enabled us to carry out a controlled intervention study in 15 preschools, with 420 children and about 40 preschool teachers, during the Covid-19 pandemic restrictions. The original overarching aim of the study was to develop and evaluate an early math intervention supporting children from low-SES environments to develop basic mathematical skills. The
Rubidium triyttrium decafluoride (RbY3F10) is a relatively unexplored low-phonon-energy fluoride host for lanthanide luminescent centers that shares structural similarities with KY3F10. In this study, Eu3+-doped RbY3F10 nanocrystals were synthesized using a microwave-assisted solvothermal method, with phase selectivity systematically controlled by pH and complexing agents. Optimized conditions (de
Purpose: Soft tissue tumors (STT) are highly heterogeneous neoplasms with more than 100 recognized subtypes, many of which lack reliable diagnostic or prognostic markers. We aimed to evaluate the clinical utility of transcriptome sequencing [RNA sequencing (RNA-seq)] in classifying STTs and identifying prognostically relevant subgroups. Experimental Design: We performed RNA-seq on 704 tumors repre
Optimization of the photoemission blade type XBPM mostly performed to increase its resolution by increasing the readout signal current and by optimizing blades geometry. This requires tailoring of the XBPM for a particular undulator, making almost every XBPM unique at the Synchrotron Radiation facility. In many cases the calibration coefficient is gap dependent. To overcome those drawbacks an alte
Background and Aims: Randomized trials of continuous positive airway pressure (CPAP) treatment for obstructive sleep apnoea (OSA) in patients with cardiovascular disease have not detected reduced risk of major adverse cardiovascular and cerebrovascular events (MACCEs). This study tested whether the cardiovascular benefit of CPAP occurs preferentially in high-risk OSA, characterized by greater OSA-
