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Direct reprogramming of immune cells holds promise for immunotherapy but is constrained by limited knowledge of transcription factor (TF) networks. Here, we developed REPROcode, a combinatorial single-cell screening platform to identify TF combinations for immune cell reprogramming. We first validated REPROcode by inducing type-1 conventional dendritic cells (cDC1s) with multiplexed sets of 9, 22,
Birds can show patterns of sexual size dimorphism as early as the nestling stage. This raises the question of how the faster growing sex might reconcile the energetic and nutritional needs of a faster growth rate with resource allocation to other important life functions, such as the development of innate immune function. Innate immunity represents the main line of defence against diseases, and wh
Global warming accelerates the breakdown of carbon stored in permafrost regions, releasing it into the atmosphere and amplifying climate change, particularly during winter when photosynthesis ceases. The Northern Hemisphere's permafrost is primarily concentrated in two key regions — the Arctic and the Tibetan Plateau — each with distinct environmental characteristics. However, previous studies oft
Memory functions are susceptible to age-related cognitive decline, making it essential to explore the underlying neurophysiological mechanisms that contribute to memory function during healthy ageing. Resting-state EEG (rsEEG) parameters, particularly the aperiodic exponent, a marker of cortical excitation-inhibition balance, and individual alpha peak frequency, a correlate of neural processing ef
PURPOSE: The local immune infiltrate's influence on tumor progression may be closely linked to tumor-intrinsic factors. The study aimed to investigate whether integrating immunologic and tumor-intrinsic factors can identify patients from a low-risk cohort who may be candidates for radiotherapy (RT) de-escalation.EXPERIMENTAL DESIGN: The SweBCG91RT trial included 1,178 patients with stage I to IIA
The 1952 General Plan for Stockholm stands among Sweden’s most ambitious postwar planning documents, often cited as evidence for or against the large-scale ambitions of Welfare State modernism. Viewed through the lens of assemblage thinking, the plan does not appear as a self-referential, determinist blueprint subsuming social space. Instead, it is read as what this chapter calls a model assemblag
What was the function of monarchy when the monarch had none? After the death of Sweden's King Charles XII in 1718, absolutism was abolished, and the new Constitution reduced the monarch to a mere figurehead. The monarchy nevertheless continued to be an indispensable part of the political system. This book explains the role of the king in the politics of the Age of Liberty (1718–1772), exploring th
This chapter will describe how educators can use uncertainty field books to explore students’ experiences as they navigate in complex and uncertain knowledge and information spaces, to engage others, and to start, grow and sustain movements for change using the groaning in the groan zone. In describing the field book, method and practice, but foremost students’ narratives, the chapter sets it up a
This chapter is situated in the intersection between a practice paper and a scienti!c paper. The authors of the chapter are researchers and teachers in teacher education and upper secondary school. All are part of a funded practice-based research project focusing on EDI (electronic digital instrument), within a national pilot project commissioned by the Swedish government from 2017 to 2024, an ini
The EDI Guidelines (https://www.ediguidelines.se), an outcome of the Swedishgovernment funded practice-based school research project “The Digital Student -Challenges and Opportunities with the Computer as an Instrument in Music Education” (2021-2024), provide a valuable resource for integrating Electronic Digital Instruments (EDI) into music education in upper secondary school. This workshop is de
Skeletal muscle capillary density is correlated with physical performance and whole-body metabolic properties. Thus, we performed a genome-wide association study of skeletal muscle capillary-to-fiber ratio (C:F) (n = 603 males) and found that the rs115660502 G allele was associated (p < 5 × 10 -8) with increased C:F and reduced skeletal muscle expression of RAB3 GTPase-activating non-catalytic p
Background: Wrist osteoarthritis can cause persistent pain, reduced joint mobility, and difficulty performing daily activities, negatively impacting quality of life. Although patient education and exercise therapy are recommended as first-line treatments for osteoarthritis in other joints, evidence supporting these strategies for wrist osteoarthritis remains limited. This randomized controlled tri
Hur formulerar man ett idéhistoriskt problem? Vilken betydelse kan plats ha i idéhistoriska undersökningar? Vilka digitala verktyg kan en idéhistoriker arbeta med? Hur skiljer sig idéhistoriska undersökningar inriktade mot medicinens, filosofins, politikens och vetenskapens historia från varandra? I den här handboken ges svar på dessa och ytterligare frågor.Boken består av tre delar som behandlar
