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Objective: A diagnosis of childhood cancer is profoundly devastating for families, with well-recognized effects on parental mental health. However, its impact on parental somatic health remains poorly understood, particularly regarding potential long-term cumulative burden. These persistent somatic diseases require frequent clinic visits for ongoing management and adversely affect parents' quality

Background: Psychological resilience refers to a person's positive adaptation when faced with adversities, such as a breast cancer (BC) diagnosis. Highly resilient patients are more likely to regain stability and be protected from health conditions such as depression, anxiety, and posttraumatic stress disorder. We aimed to identify epigenetic markers that distinguish high- and low-resilient patien

Geomagnetic field models constrained by direct observations extend back some 400 years and the magnitude of decadal to centennial variations that they display is often assumed to be typical of the secular variation over longer timescales. Here we present archaeomagnetic directions from layered Neolithic hearths in Orkney, dating to around 3000 BCE, that challenge this assumption. Combining stratig

Polystyrene micro- and nanoplastics (PS-MNPs) are emerging environmental pollutants with potential implications for human health. This study investigated the cytotoxic effects of PS particles by using two different sizes of PS-MNPs (0.25 µm and 1 µm) on non-small cell lung cancer (A549, H460), small cell lung cancer (DMS53, H372), and normal lung epithelial (BEAS-2B) cells as well as on human-deri

This article explores how public transportation workers and passengers conceptually can be brought together. This is well worth discussing because of how these two positions are interconnected and simultaneously impacted by how public transportation is organized and operated. This applies to for example increased efficiency measures and digitalization, possibly well received by some passengers whi

Background: Colorectal cancer (CRC) is shaped by a complex tumor immune microenvironment in which inflammatory mediators like cyclooxygenase-2 (COX-2) and immune checkpoints such as programmed cell death ligand 1 (PD-L1) play central regulatory roles. However, the prognostic significance of these makers, individually and in combination with T-cell infiltration, remains poorly defined.Methods: We i

This dataset presents a comprehensive collection of microscopic images, infrared (IR) spectra of particles obtained from beach sediment in Tioman Island, Malaysia. Sediment samples were collected from multiple sites across three selected beaches to identify material composition and assess the concentration of plastic particles, including both microplastics (<5 mm) and macroplastics (>5 mm), in the

A complication in the treatment of any strongly charged particle is the SU(3) color structure. For the standard model quarks, antiquarks and gluons there are various well-known strategies for dealing with the color structure, including orthogonal multiplet bases. For exotic representations, beyond triplets, antitriplets and octets, non-orthogonal bases have been systematically worked out only rece

This study systematically investigates the passivation and dissolution mechanisms of TC4 (Ti-6Al-4V) in 3.5 wt% NaCl solution using in situ electrochemical atomic force microscopy (ECAFM), complemented by X-ray photoelectron spectroscopy (XPS) and X-ray absorption spectroscopy (XAS). Potentiodynamic polarization initially identified the electrochemical behavior of TC4, delineating passive, dissolv

Antennae, the primary sensory organs of insects, contain numerous sensilla responsible for detecting chemical and physical stimuli essential for host location, communication, and orientation. Although the antennal sensilla of many insect groups—including Gelechiidae—have been well characterized, no such descriptions exist for Anacampsis phytomiella (Busck, 1914), a pest that exclusively infests ca

This study examined the role of a daytime nap in the consolidation and generalization of fear learning. 31 healthy, young adult participants (16 in the wake group and 15 in the sleep group) underwent a fear acquisition procedure in which the conditioned stimulus (CS+), a composite image consisting of a geometrical figure imposed on a background, was repeatedly paired with a mild electric shock. Th

This paper explores ‘utopia as method’ to envision solid waste and sewage management systems which are equitable and sustainable. Global solid waste management is largely sustained by millions of waste pickers who collect, sort and manage waste. Sanitation workers play a vital role in maintaining sewage systems. These workers are exposed to dangerous, toxic workspaces, and they often belong to mar

The urgency of global climate change and other geological-scale anthropogenic impacts also suggests new perspectives on economic history. This thesis argues for the inclusion into economic history of more Earth-system centred feedbacks, both in terms of environmental and climatic consequences and environmental and climatic causes, where consequences in one realm may again become causal in the othe

This is a protocol for a Cochrane Review (intervention). The objectives are as follows: Primary objective To evaluate the benefits and harms of intratracheal instillation of corticosteroids combined with surfactant versus surfactant alone for the preventing chronic lung disease in preterm infants. Secondary objective To identify equity issues that may be associated with the implementation, uptake,

Tuberculosis (TB), caused by Mycobacterium tuberculosis, remains one of the deadliest infectious diseases worldwide. In 2023, it accounted for approximately 1.25 million deaths, including 161,000 among individuals living with HIV, making it the leading cause of death from a single infectious agent. The growing prevalence of multidrug-resistant TB (MDR-TB) further complicates treatment and contribu

Epithelial ovarian cancer (EOC) is the most lethal gynecologic malignancy, yet clinical tools for diagnosis, prognosis, and treatment remain limited, and molecular profiling of histotypes is lacking. Here, we leverage proteomic data to further stratify four main EOC histotypes, borderline (BL) and benign (B) tumors, and identify candidate prognostic and diagnostic biomarkers. Using proteomic data

Hair analysis has been used in the past as a method to explore environmental exposure to chemicals, toxins or drug ingestion, with wide applications in forensic science, environmental studies, anthropology and medicine. Although not a conventional sample type, hair offers significant advantages over traditional biospecimens, such as blood or urine. These include its stability, non-invasive nature