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We devise an autonomous quantum thermal machine consisting of three pairwise-interacting qubits, two of which are locally coupled to thermal reservoirs. The machine operates autonomously, as it requires no time-coherent control, external driving or quantum bath engineering, and is instead propelled by a chemical potential bias. Under ideal conditions, we show that this out-of-equilibrium system ca
Substance P, previously dismissed as a therapeutic target for migraine due to the failure of neurokinin-1 receptor antagonists, warrants renewed attention. Building on the success of therapies targeting the calcitonin gene-related peptide (CGRP) system and pituitary adenylate cyclase-activating peptide (PACAP) in migraine prevention, which highlight the importance of targeting peptides, this propo
Lipoproteins, key mediators of lipid transport, facilitate the bidirectional transfer of lipids such as fatty acids, triglycerides, and cholesterol between soluble particles and cell membranes. High-density lipoproteins (HDL) primarily engage in reverse cholesterol transport, while low-density lipoproteins (LDL) predominantly deposit lipids, affecting cardiovascular health with a well-known role i
Background: Cortical atrophy is a common manifestation in behavioral variant frontotemporal degeneration (bvFTD), exhibiting spatial heterogeneity across various genetic subgroups, which may be driven by distinct biological mechanisms. Methods: We employed an integrative imaging transcriptomics approach to identify both disparate and shared transcriptomic signatures associated with cortical thickn
The identity and source of flexible, semi-transparent, vascular-like components recovered from non-avian dinosaur bone are debated, because: (1) such preservation is not predicted by degradation models; (2) taphonomic mechanisms for this type of preservation are not well defined; and (3) although support for molecular endogeneity has been demonstrated in select specimens, comparable data are lacki
Background and aim. In rural areas, economic and demographic shifts often leave buildings vacant due to functional and locational obsolescence. However, these buildings hold significant value in terms of embodied energy, natural resources, economic capital, and cultural heritage. The real estate sector urgently needs innovative space use strategies and business models to tackle rising vacancy rate
Background and aim.The pandemic accelerated green and digital transition may benefit smaller towns. New opportunities include multi-locational living and working, emerging industries, and novel services to attract creative industries. All these developments entail more freedom for people to choose their place of living. Meanwhile, the real estate sector is in dire need of novel space use concepts
BACKGROUND: Previous studies of glucagon stimulation test (GST) in children have shown variable results regarding the utility and reliability of the cortisol response to this test and its correlation with clinical parameters. The aim of this study was to assess cortisol levels at GST and to evaluate how clinical parameters, such as age, sex, pubertal status and Body Mass Index (BMI), correlate to
Overtourism has emerged as a pressing challenge for many destinations, but its manifestations and impacts vary in different geographical and socio-political contexts. This chapter examines overtourism as a situated phenomenon from a Nordic perspective, focusing on how place-based conflicts arise in urban and peri-urban areas. Drawing on instances from different locations, we analyse the ways in wh
This paper discusses how archaeologists might investigate issues of poverty by focusing on poorhouses. The poor and deprived are rarely prominent objects in archaeological research, probably because archaeologists find it difficult to relate to a concept such as poverty. At the same time, there is material culture that can be clearly linked to poverty. One such materiality is poorhouses. While the
BACKGROUND: Risk stratification tools for paediatric community-acquired pneumonia (CAP) in well-resourced settings are scarce. We prospectively developed models to predict CAP severity within a multinational cohort of paediatric emergency departments (EDs). Our primary objective was to develop a risk prediction model to discriminate between mild CAP and moderate or severe CAP to assist clinicians
Foreign aid for media development has often been associated with the promotion of specific models or ideals for journalism. Efforts by national aid agencies, NGOs, UNESCO, and media organisations have aimed to support journalists worldwide. However, due to limitations in financial sustainability, inadequate media structures, and competing journalistic ideologies in recipient countries, the impact
Over recent years many urban areas have experienced severe floods caused by extreme precipitation events. To avoid the devastating socioeconomic and environmental consequences of such floods, countries have issued laws or recommendations on flood risk assessment in urban planning. However, these laws or recommendations seldom include detailed requirements on input data quality or explicit instruct
In this editorial, we discuss why disclosure of many aspects commonly seen in positionality statements may be problematic given the cultural and legal context surrounding personal information in Europe, and the unequal distribution of required bravery, experienced burdens and barriers. We summarize current norms and problems with requiring labels, and suggest that, rather than disclosing identity
BACKGROUND: Opioid-free anaesthesia (OFA) may enhance postoperative recovery after bariatric surgery, but its combined effect with opioid-free interventions has not been studied.OBJECTIVES: To compare postoperative pain and recovery after laparoscopic bariatric surgery with a total opioid-free care pathway and conventional opioid-based treatment.DESIGN: A multicentre nonblinded controlled trial.SE
An ‘implementation gap’ between law and practice has long been noticed by scholars and practitioners of children’s rights. This chapter goes beyond critiquing such a gap by unpacking and deconstructing the very notion of ‘implementation.’ It empirically studies how India’s national child helpline, and thereby children’s protection rights, are implemented in the state of Madhya Pradesh in North Ind
The curve number (CN) method, developed by the Natural Resources Conservation Service (NRCS), is one of the most widely used approaches worldwide to estimate runoff from rainfall events. However, one of the remaining uncertainties in the method remains whether to apply a frequency-matched or natural data approach for computing the CN from rainfall-runoff data. To address this knowledge gap, this s
Pathogenic mycobacteria require the conserved ESX-1 type VII secretion system to cause disease. In a murine Mycobacterium marinum infection model we previously demonstrated that infiltrating monocytes and neutrophils represent the major bacteria-harbouring cell populations in infected tissue. In the current study we use this model, in combination with scRNA sequencing, to assess the impact of M. m
Identifying specific inhibitors of the MYC oncogene has been challenging, due to off target effects associated with MYC inhibition. This study investigated how the recombinant Escherichia coli Lon protease (rLon), which targets MYC in human cells, inhibits MYC over-activation in models of infection and cancer. In silico predictions identified specific peptide domains of bacterial Lon that target M
