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Autoantibodies to dense fine speckles 70 (DFS70) are purported to rule out the diagnosis of SLE when they occur in the absence of other SLE-related autoantibodies. This study is the first to report the prevalence of anti-DFS70 in an early, multinational inception SLE cohort and examine demographic, clinical, and autoantibody associations. Patients were enrolled in the Systemic Lupus International
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This paper presents a robust phase-based positioningframework using a massive multiple-input multiple-output(MIMO) system. The phase-based distance estimates of MPCstogether with other parameters are tracked with an ExtendedKalman Filter (EKF), the state dimension of which varies withthe birth-death processes of paths. The iterative maximumlikelihoodestimation algorithm (RIMAX) and the modeling of
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In this paper we present a new method for creating polynomialsolvers for problems where a (possibly infinite) subsetof the solutions are undesirable or uninteresting. Thesesolutions typically arise from simplifications made duringmodeling, but can also come from degeneracies which areinherent to the geometry of the original problem.The proposed approach extends the standard action matrixmethod to
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It has been proposed that the local segregation of kinases and the tyrosine phosphatase CD45 underpins T cell antigen receptor (TCR) triggering, but how such segregation occurs and whether it can initiate signaling is unclear. Using structural and biophysical analysis, we show that the extracellular region of CD45 is rigid and extends beyond the distance spanned by TCR-ligand complexes, implying t
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Development of single-molecule localization microscopy techniques has allowed nanometre scale localization accuracy inside cells, permitting the resolution of ultra-fine cell structure and the elucidation of crucial molecular mechanisms. Application of these methodologies to understanding processes underlying DNA replication and repair has been limited to defined in vitro biochemical analysis and
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An important and characteristic property of a cell membrane is the lateral mobility of protein molecules in the lipid bilayer. This has conventionally been measured by labeling the molecules with fluorescent markers and monitoring their mobility by different fluorescence-based techniques. However, adding the label to the studied molecule may affect the system, so it is an assumption in almost all