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Migraine is one of the most common of neurological disorders with a global prevalence of up to 15%. One in five migraineurs have frequent episodic or chronic migraine requiring prophylactic treatment. In recent years, specific pharmaceutical treatments targeting calcitonin gene-related peptide (CGRP) signalling molecules have provided safe and effective treatments; monoclonal antibodies for prophy
X-ray propagation-based imaging techniques are well established at synchrotron radiation and laboratory sources. However, most reconstruction algorithms for such image modalities, also known as phase-retrieval algorithms, have been developed specifically for one instrument by and for experts, making the development and diffusion of such techniques difficult. Here, PyPhase, a free and open-source p
PURPOSE: Despite impressive response rates following adoptive transfer of autologous tumor-infiltrating lymphocytes (TILs) in patients with metastatic melanoma, improvement is needed to increase the efficacy and broaden the applicability of this treatment. We evaluated the use of vemurafenib, a small-molecule BRAF inhibitor with immunomodulatory properties, as priming before TIL harvest and adopti
Antibodies are central to acquired immunity against malaria. Plasmodium falciparum elicits antibody responses against many of its protein components, but there is also formation of antibodies against different parts of the red blood cells, in which the parasites spend most of their time. In the absence of a decisive intervention such as a vaccine, people living in malaria endemic regions largely d
Surrogate measures of safety (SMoS) are meant to be an alternative/complement to crash data that enables a proactive approach to traffic safety. Validity is a fundamental property of SMoS that describes how well they reflect the quality of interest – traffic safety. However, typical validation studies are extremely resource demanding. Therefore, the aim of this study was to explore a relative appr
The Bicoid (Bcd) protein is a primary determinant of early anterior-posterior (AP) axis specification in Drosophila embryogenesis. This morphogen is spatially distributed in an anterior-high gradient, and affects particular AP cell fates in a concentration-dependent manner. The early distribution and dynamics of the bicoid (bcd) mRNA, the source for the Bcd protein gradient, is not well understood
Background: The formation of the Bicoid (Bcd) gradient in the early Drosophila is one of the most fascinating observations in biology and serves as a paradigm for gradient formation, yet its mechanism is still not fully understood. Two distinct models were proposed in the past, the SDD and the ARTS model.Results: We define novel cis- and trans-acting factors that are indispensable for gradient for
Understanding the molecular basis of sexual dimorphism in the cardiovascular system may contribute to the improvement of the outcome in biological, pharmacological, and toxicological studies as well as on the development of sex-based drugs and therapeutic approaches. Label-free protein quantification using high-resolution mass spectrometry was applied to detect sex-based proteome differences in th
Inequalities for S, P and D ππ partial waves are derived using crossing symmetry and positivity.
We investigate reactions between high-energy oxygen and carbon nuclei and various nuclear targets. The beam nucleus is described by an α-particle model and the reaction products are classified into groups corresponding to inelastic collisions of one, two, three and four alpha particles. Excellent agreement with experiment is obtained.
The present study describes the testing and function of the drop-volume method in the analysis of fetal lung maturity with use of amniotic fluid. Elevated surface tension resulting from a lack of surface-active phospholipids (surfactant) is the primary etiologic defect in the development of respiratory distress syndrome. The drop-volume method quantifies the surface tension of amniotic fluid with
Introduction: The aim of the study is to compare the effect of cervical length measured with transvaginal ultrasound in the second trimester on the risk of spontaneous preterm delivery (PTD) between different risk groups of asymptomatic women with a singleton pregnancy. Material and methods: This is a pre-planned exploratory analysis of the CERVIX study, a prospective blinded multicenter diagnosti
Nearly all major corporations and many public agencies have established ethics and compliance departments, some of them as the result of penalties imposed by the US Dept. of Justice, others due to embarrassing scandals. The responsibilities of these ethics and compliance departments range from inculcating internal codes of conduct within the organization, preventing bribery in contracts, impeding
Abstract: Citizen-state relations can be more than just a political relationship. It can also be emotional. Where there is an articulated balance between citizen tax obligations and state welfare services, there arises a combination of redistribution and reciprocity between citizen and state. This fiscal compact has an emotional component. This emotional component becomes indignation when people p
A search is performed for the electroweak pair production of charginos and associated production of a chargino and neutralino, each of which decays through an R-parity-violating coupling into a lepton and a W, Z, or Higgs boson. The trilepton invariant-mass spectrum is constructed from events with three or more leptons, targeting chargino decays that include an electron or muon and a leptonically
A search for charged Higgs bosons decaying into a top quark and a bottom quark is presented. The data analysed correspond to 139 fb−1 of proton-proton collisions at s = 13 TeV, recorded with the ATLAS detector at the LHC. The production of a heavy charged Higgs boson in association with a top quark and a bottom quark, pp → tbH+ → tbtb, is explored in the H+ mass range from 200 to 2000 GeV using fi
Nuclear technology and the use of radiation sources have been extensively adopted in the modern world. Despite that, a number of radiological accidents, significantly affecting population and the environment, has happened. Few of the most known are accidents in Chernobyl and Fukushima nuclear power plants. As a result, significant areas are still contaminated with some residential areas evacuated
Background: Long-term follow-up (LTFU) care for childhood, adolescent, and young adult (CAYA) cancer survivors is essential to preserve health and quality of life (QoL). Evidence-based guidelines are needed to inform optimal surveillance strategies, but many topics are yet to be addressed by the International Late Effects of Childhood Cancer Guideline Harmonization Group (IGHG). Therefore, the Pan
