Filtyp
Integrins are transmembrane receptors that, upon activation, bind extracellular ligands and link them to the actin filament (F-actin) cytoskeleton to mediate cell adhesion and migration. Cytoskeletal forces in migrating cells generated by polymerization- or contractility-driven “retrograde flow” of F-actin from the cell leading edge have been hypothesized to mediate integrin activation for ligand
A sorption isotherm expresses the relation between ambient relative humidity (RH) and equilibrium moisture content of a material for a specific temperature. The sorption isotherm can generally be divided into a hygroscopic part covering low, medium and high RH levels, and an over-hygroscopic part close to 100% RH. For wood, the hygroscopic part is dominated by water uptake in cell walls and the ov
A dominant conceptualization of empathy in social work practice and education, provided by Karen Gerdes and Elizabeth Segal, relies heavily on the simulation theory adopted directly from the cognitive neurosciences. The aim was to critically challenge such a view by reporting on some recent empirical findings from the field in which professional social workers were interviewed about their experien
We studied if hydrogen (δD) and oxygen (δ18O) stable isotope values in three common carabid species in intensively managed agricultural landscapes in southernmost Sweden indicate long-range dispersal. We matched “emerging” (emergence tents) and “colonizing” (pitfall traps) individuals of three carabid species (Trechus quadristriatus, Harpalus rufipes, Pterostichus melanarius) to account for spatia
According to the fitting-attitude analysis of value (FA-analysis), to be valuable is to be a fitting object of a pro-attitude. In earlier publications, setting off from this format of analysis, I proposed a modelling of value relations which makes room for incommensurability in value. In this paper, I first recapitulate the value modelling and then move on to suggest adopting a structurally simila
Scrapping programmes and individual transferable quotas (ITQs) are two management measures frequently used to reduce overcapacity in fisheries. These measures are often aimed at specific vessel segments targeting specific fish stocks. In this case, fishermen who scrap their vessels or sell their quotas may shift their fishing activities, possibly contributing to overcapacity in other fleets. The a
Sand grains from Quaternary glacial, aeolian and fluvial deposits in the Mazovian Lowland, central Poland, were examined to characterize the effects of different Quaternary processes on sand-grain surfaces that experienced repeated cycles of intense polar-desert-like conditions during the Middle and Late Pleistocene. A cold, dry and windy periglacial environment prevailed here at least twice betwe
Objective: We aimed to study the association between neighborhood socioeconomic status at the age of 40 years and risk of ischemic stroke before the age of 50 years. Methods: All individuals in Sweden were included if their 40th birthday occurred between 1998 and 2010. National registers were used to categorize neighborhood socioeconomic status into high, middle, and low and to retrieve informatio
The mechanisms that mediate the interaction between the thermal environment and species ranges are generally uncertain. Thermal environments may directly restrict species when environments exceed tolerance limits (i.e. the fundamental niche). However, thermal environments might also differentially affect relative performance among species prior to fundamental tolerances being met (i.e. the realize
Among hereditary colorectal cancer predisposing syndromes, Lynch syndrome (LS) caused by mutations in DNA mismatch repair genes MLH1, MSH2, MSH6 or PMS2 is the most common. Patients with LS have an increased risk of early onset colon and endometrial cancer, but also other tumors that generally have an earlier onset compared to the general population. However, age at first primary cancer varies wit
Diverse radiations of insects are often associated with adaptations to host plants, and well-resolved phylogenetic relationships are required to fully understand them. Palearctic Argynnis and related subgenera, together with North American Speyeria butterflies make up a radiation whose species hypotheses are confounded by shared wing colour patterns between sympatric populations of closely related
Background Supraventricular ectopic complexes (SVEC) originating in the pulmonary veins are known triggers of atrial fibrillation (AF) which led to the development of pulmonary vein isolation for AF. However, the long-term prevalence of SVEC after catheter ablation (CA) as compared to antiarrhythmic medication (AAD) is unknown. Our aims were to compare the prevalence of SVEC after AAD and CA and t
Background: Current information on mortality attributed to stroke among different countries is important for policy development and monitoring prevention strategies. Unfortunately, mortality data reported to the World Health Organization by different countries are inconsistent. Aims and/or hypothesis: To update the repository of the most recent country-specific data on mortality from stroke for co
Importance: Active surveillance is an important option to reduce prostate cancer overtreatment, but it remains underutilized in many countries. Models from the United States show that greater use of active surveillance is important for prostate cancer screening to be cost-effective.Objectives: To perform an up-to-date, nationwide, population-based study on use of active surveillance for localized
Objectives/Hypothesis: Data from patients registered for myringoplasty during 2002 to 2012 in the Swedish National Quality Registry for Myringoplasty. Study Design: Both conventional myringoplasty and fat-graft techniques were used aimed at healing the tympanic membrane in noninfected ears. Methods: Analysis was performed on data in a national database collected from 32 ear, nose, and throat clini
To evaluate the shared genetic etiology of type 2 diabetes (T2D) and coronary heart disease (CHD), we conducted a genome-wide, multi-ancestry study of genetic variation for both diseases in up to 265,678 subjects for T2D and 260,365 subjects for CHD. We identify 16 previously unreported loci for T2D and 1 locus for CHD, including a new T2D association at a missense variant in HLADRB5 (odds ratio (
The interplay between shape anisotropy and directed long-range interactions enables the self-assembly of complex colloidal structures. As a recent highlight, ellipsoidal particles polarized in an external electric field were observed to associate into well-defined tubular structures. In this study, we systematically investigate such directed self-assembly using Monte Carlo simulations of a two-poi
Tuning the solubility of fuzzy polymer microgels by external triggers, such as temperature or pH, provides a unique mechanism for controlling the porosity and size of colloidal particles on the nanoscale. As a consequence, these smart microgel particles are being considered for applications ranging from viscosity modifiers and sensing to drug delivery and as models for the glass and the jamming tr
Background: Betel nut (BN) or areca nut (AN) chewing habits on its own or with other ingredients including chewing tobacco are highly prevalent in many South East Asian countries as well as among the migrants from these countries residing around the world. The major alkaloid arecoline in the BN has been found to carcinogenic and to be associated with a range of health risks, including negative eff
